Klinická farmakologie a farmacie č. 3/2020

Redakce

Klin Farmakol Farm. 2020;34(3)  

Slovo úvodem

Jiří Vlček

Klin Farmakol Farm. 2020;34(3):98  

Evaluation of geriatric drug‑disease interactions in seniors in log‑term care in the Czech Republic

Daniela Fialová, Veronika Příhodová, Jovana Brkič, Ingrid Kummer, Silvia Grešáková, Anna Lukačišinová, Eva Topinková

Klin Farmakol Farm. 2020;34(3):99-107 | DOI: 10.36290/far.2020.019  

Introduction: Prescribing of non-geriatric dosing, inappropriate indications and drug-disease interactions in older patients create specific areas of high-risk prescribing in geriatrics that often lead to drug-related complications, particularly in polymorbid older patients using polypharmacy and having higher degree of frailty. The European project SHELTER (Services and Health in the Elderly in Long-TERrm care, 7^th FP, 2009-2014) aimed at describing comprehensive characteristics of 4 156 long-term care seniors (including drug prescribing habits) in 7 EU countries (Czech Republic, Italy, Germany, Netherlands, Finland, UK, France) and Israel....

Food as an important part of maximizing the effect and minimizing the risks of pharmacotherapy - absorption and gastrointestinal tolerance

Ondřej Tesař, Veronika Měrková, Martin Doseděl, Josef Malý

Klin Farmakol Farm. 2020;34(3):108-115 | DOI: 10.36290/far.2020.020  

Introduction and aim: Food can significantly affect the therapeutic value of a drug, therefore, it is necessary to keep it in mind when creating an individual treatment plan for a patient. The active involvement of physician, pharmacist, nurse, nutritional therapist, and patient is essential to identify, evaluate, and manage the food-drug interaction. The aim of this paper was to analyse oral drugs marketed in the Czech Republic, in which food affects their absorption or gastrointestinal tolerance. Secondly, to provide opportunity to apply identified information in clinical practice in terms of pharmacotherapy individualization with respect to efficacy...

Drug‑related problems in theory and practice in the Czech Republic

Josef Malý

Klin Farmakol Farm. 2020;34(3):116-121 | DOI: 10.36290/far.2020.021  

Patient safety issues are still a current problem, both for its impact on public health and for high economic burden. The aim of this paper is to demonstrate and discuss aspects associated with the safety culture in the provision of pharmacotherapy with emphasis on drug-related problems (DRP) and methods of their identification in the Czech Republic. DRPs are a link between healthcare professionals and medication review is a way by which pharmacists can manage DRPs at various levels.

Clinical pharmacy in geriatrics and 20 years of clinical and scientific experience with the evaluation of rationality of geriatric drug prescribing in the Czech republic and European countries

Daniela Fialová, Milada Halačová, Jovana Brkič, Silvia Grešáková, Ingrid Kummer, Eva Topinková, Božena Jurašková

Klin Farmakol Farm. 2020;34(3):122-129  

Publication summarizes activities realized in the past 20 years (2000-2020) in the development of clinical pharmacy in geriatrics in clinical and scientific areas. In clinical area it emphasizes specific features of rational geriatric pharmacotherapy in comparison to classical internal medicine and specific aspects of evaluation and individualization of drug schemes in older patients. It highlights important role of clinical pharmacists as specialists in the field of clinical pharmacy in individualization of drug schemes and reguirements of deep knowledge of clinical pharmacy in geriatrics, risk-management, applied geriatric pharmacology, current geriatric...

Drugs induced dysnatremia: I. Drug hyponatremia

Milada Halačová, Dalibor Černý, Kateřina Sadilová

Klin Farmakol Farm. 2020;34(3):130-134 | DOI: 10.36290/far.2020.023  

Hyponatremia is a relatively common and serious complication in outpatient and hospitalized patients. It is associated with increased mortality and morbidity. The clinical manifestation is very diverse and its development is due to a large number of causes, including iatrogenic drug-induced . The factors involved in the development of hyponatremia may be mutually combined, the causes are often not clearly identified and therefore drug hyponatremia remains undetected and underdiagnosed. The aim of this paper is to provide a literature review of the potential of individual drugs to induce hyponatremia, to describe the pathophysiological mechanism of...

The present perspective on the administration of intravenous immunoglobulins in patients with toxic epidermal necrolysis

Břetislav Lipový, Petra Bořilová Linhartová

Klin Farmakol Farm. 2020;34(3):135-141 | DOI: 10.36290/far.2020.024  

Toxic epidermal necrolysis is a rare life-threatening disease dominantly manifesting on the skin but frequently affecting mucosa as well. The clinical symptomatology results from a pathophysiological process causing massive apoptosis of keratinocytes, dominantly those in the dermal-epidermal junction. This, in turn, leads to a formation of a bulla and a separation of practically the entire epidermis, exposing the dermis. Although the complex pathophysiological background of this disorder has not been fully clarified yet, the interaction at the level of the Fas ligand and Fas receptor is considered the dominant pathway leading to this condition. Intravenous...

An unexpected cause of delirium

Jiří Holý, Martin Holý, Zdeněk Beneš, Marie Pešková

Klin Farmakol Farm. 2020;34(3):142-145 | DOI: 10.36290/far.2020.025  

The authors document case history of an 70 years old male patient with hypertension, diabetes mellitus of 2^nd type and dyslipidaemia, after a potentially curative treatment of carcinoma of the prostate gland, suffering from a contusion of right lower extremity followed by a lesion of nervus ischiadicus. The patient took glimepiride 2 mg daily, rosuvastatin 20 mg daily, ramiprilum 5 mg and amlodipine 10 mg in fixed- dose combination and escitalopram 10 mg daily before an admission. The wounded man suffers from the development of rhabdomyolysis with acute renal failure. Repeated delirious status caused by hypoglycaemia appears by the patient...