Interakce mezi mykofenolát mofetilem a takrolimem u pacientů po transplantaci ledviny

Jan Strojil, Jiří Orság, Tomáš Fürst, Karel Urbánek, Pavel Anzenbacher, Karel Krejčí

Klin Farmakol Farm. 2017;31(3):3-6 | DOI: 10.36290/far.2017.032  

Cíle: Takrolimus je základem imunosuprese u příjemců transplantované ledviny. Nejčastěji je užíván v kombinaci s mykofenolátmofetilem. Údaje o existenci a významu interakce těchto dvou léků u pacientů po transplantaci ledvin jsou protichůdné a nejednoznačné.Cílem této studie bylo potvrdit a kvantifikovat tuto interakci u pacientů po transplantaci ledvin.Metody: Bylo analyzováno celkem 4 220 měření hladin takrolimu v období 5 let u 181 pacientů s renálním štěpem v jednomtransplantačním centru. Změna dávky potřebné k dosažení jednotkové koncentrace byla použita jako náhradní parametr propopis variability clearance léku. Regresní multivariační model byl...

Could pregabaline be effective medication in treatment of depressive disorder?

Miroslav Sekot

Klin Farmakol Farm. 2017;31(3):7-8 | DOI: 10.36290/far.2017.015  

Pregabalin belongs to a group of antiepileptics and it is indicated for the treatment of generalized anxiety disorder and neuropaticpain. Although the antidepressant effect of pregabalin has not been proven, pregabalin can positively affect the mood of patientswith pain syndromes of various etiologies. Two case studies of pregabalin treatment in patients with depressive symptomatologyare described in this article.

Long-acting injectable antipsychotics in clinical practice

Libor Ustohal

Klin Farmakol Farm. 2017;31(3):10-15 | DOI: 10.36290/far.2017.016  

The article summarizes basic data concerning long-acting injectable or depot antipsychotics, which are currently available in theCzech Republic. They include four first generation antipsychotics (fluphenazine, flupenthixol, haloperidol and zucklopenthixol)and four second generation antipsychotics (aripiprazole, olanzapine, risperidone and paliperidone). It focuses especially on thetreatment initiation and dosage regimen. Basic advantages and disadvantages of depot formulation are discussed as well as itsefficacy in the prevention of relapse and the risk of adverse-events compared to oral formulation of antipsychotics.

Magnesium supplementation: pharmacological mechanisms, routes of administration, and pitfalls

Zdeněk Zadák, Alena Tichá, Radomír Hyšpler

Klin Farmakol Farm. 2017;31(3):16-18 | DOI: 10.36290/far.2017.017  

Magnesium is a significant factor in a whole range of metabolic reactions, particularly in energy production, in mitochondrialfunction, being a part of enzyme cofactors and modulating the function of transport pumps and cell membrane channels.Magnesium deficiency is very common in the population of industrialized countries, ranging around 33% in all male and femaleage groups. The diagnosis of magnesium depletion in the body is difficult, given that this ion is present in biological systems inseveral fractions and, furthermore, because its maximum is contained intracellularly. The clinical symptomatology of magnesiumdepletion is very broad, ranging...

Antiresorptive substances and osteonecrosis of the jaws from point of view of stomatology

Peter Plachý, Katarína Sobolíková, Peter Stanko

Klin Farmakol Farm. 2017;31(3):19-22 | DOI: 10.36290/far.2017.033  

Significant group of antiresorptive substances are bisphosphonates (abbr. BP). They inhibit diferentiation and maturationof osteoclasts, decrease bone resorption. Main indications of the BP are multiple myeloma, Paget´s disease, bone metastasesby cancer of prostata, breast cancer, kidney malignancies etc. and by osteoporosis. As negative effect of the BP revealsdevelopment of jaw osteonecrosis in some cases, by the American Association for Oromaxilofacial Surgery named BRONJ –bisphosponate related osteonecrosis of the jaws or MRONJ – medication related osteonecrosis of the jaws respectively.Incidence of the osteonecrosis by oral use of...

Intrathecal drug administration in cancer patient with refractory pain

Jana Gregorová, Petra Holečková

Klin Farmakol Farm. 2017;31(3):23-27 | DOI: 10.36290/far.2017.034  

An oncological 69-year-old patient with a diagnosis of rectosigma carcinoma after successful conservative treatment of spondylitiswas treated with progression of pain that significantly restricted him not only in usual daily activities, but mainly prevented himfrom lying down. The effect of systemic administration of high doses of opioids, supplemented with non-steroidal anti-inflammatoryand co-analgesics, was not sufficient.

Evolocumab for the treatment of familial hypercholesterolemia

Vladimír Bláha

Klin Farmakol Farm. 2017;31(3):28-34 | DOI: 10.36290/far.2017.035  

Familial hypercholesterolaemia (FH) is the most common dominantly inherited monogenic disorder in human beings worldwide.Familial hypercholesterolaemia is caused by mutations in genes encoding key proteins involved in low density lipoproteincholesterol (LDL-C) metabolism, which leads to reduced cellular uptake of LDL cholesterol, increased plasma LDL cholesterolconcentrations, and premature development of cardiovascular disease. Despite the availability of reliable diagnostic criteria (highLDL-C levels, family history or premature CHD and hypercholesterolemia, cerebral/peripheral vascular disease, and the presenceof tendon xanthomata or presence of...

Odefsey and its current role in treating HIV infection

David Jilich

Klin Farmakol Farm. 2017;31(3):35-37 | DOI: 10.36290/far.2017.019  

Antiretroviral treatment is the only generally accepted method for treating HIV infection. Given the need for long-term andeveryday use of antiretroviral drugs, it is important to use not only highly effective, but also safe and well tolerated medicinalproducts. Recently, major emphasis has been placed on patient comfort in long-term treatment. Single-tablet regimens are atthe cutting edge in this regard, with one of them being Odefsey.

Zemřel prof. MUDr. Karel Trnavský, DrSc.

Prof. MUDr. Štefan Alušík, CSc.

Klin Farmakol Farm. 2017;31(3)