Klin Farmakol Farm. 2026;40(2):124-128 | DOI: 10.36290/far.2026.008

Specifics of corticosteroid administration in patients with central nervous system diseases with a focus on neurointensive care

Lucie Sauerová
Úsek klinické farmacie, Nemocniční lékárna, Fakultní nemocnice Brno
Lékařská fakulta, Masarykova univerzita, Brno

Corticosteroids (CST) play a key role in the treatment of oncological, infectious, and autoimmune diseases of the central nervous system (CNS). CST reduces inflammatory processes and is used mainly to reduce brain edema and intracranial pressure, thereby significantly improving the quality of life of patients. They are also administered as substitution therapy in the context of a functional deficit of the pituitary gland or hypo­thalamus. Administration is not indicated universally in all patients. Before use, we should evaluate the risk/benefit, i. e., the severity of the clinical manifestations of the disease and the risk of adverse effects, and in infectious diseases, also the causative agent. The article focuses on the administration of corticosteroids in neurointensive care and in patients with CNS infections. It does not address the treatment of oncological and autoimmune diseases.

Keywords: corticosteroids, central nervous system, indications, neurosurgery, dexamethasone, fludrocortisone, neuroinfections.

Received: December 10, 2025; Revised: February 20, 2026; Accepted: February 20, 2026; Published: July 1, 2026  Show citation

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Sauerová L. Specifics of corticosteroid administration in patients with central nervous system diseases with a focus on neurointensive care. Klin Farmakol Farm. 2026;40(2):124-128. doi: 10.36290/far.2026.008.
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