Klin Farmakol Farm. 2017;31(4):14-17 | DOI: 10.36290/far.2017.023

Chondroitin, glucosamine, diacerein, piascledine, and methylsulphonylmethane in the prevention and treatment of joint diseases

Martin Hobza, Jiří Gallo

Ortopedická klinika Lékařské fakulty Univerzity Palackého v Olomouci a Fakultní nemocnice Olomouc

Metabolic disorders and inflammatory processes in cartilage tissue have a pivotal role in the course of degenerative and otherjoint diseases. These processes are aimed at by orally administered medication for treatment of osteoarthritis and joint symptoms.Some of these substances stimulate recovery of the extracellular matrix in the cartilage, take part in its metabolic regulation andsupress inflammatory changes to a certain extent. These drugs have a slow onset of effect, alleviate symptoms and are thoughtto have a disease-modifying effect. Chondroitin sulfate and glucosamine sulfate are most commonly used and best studied; lessinformation is available for diacerein, piascledine and methylsulfonylmethane. An agreement on their clinical usefulness is yet tobe found. Most of the clinical societies involved in osteoarthritis treatment recommend administering these substances. However,significance of this intervention can differ in various guidelines.

Keywords: cartilage, osteoarthritis, chondroitin sulfate, glucosamine sulfate, diacerein, piascledine, methylsulfonylmethane

Published: January 1, 2018  Show citation