Klin Farmakol Farm. 2017;31(2):7-13 | DOI: 10.36290/far.2017.010

Macrolides Drug Interactions in 2017

Michal Prokeš, Ondřej Suchopár, Josef Suchopár
DrugAgency, a. s.

Macrolide antibiotics are popular antibiotic but they cause numerous drug-drug Interactions. Clarithromycin and roxithromycinare inhibitors of CYP3A4. This can harm patients using simvastatin, atoarvastatin, verapamil, diltiazem and other substrates ofCYP3A4. Clarithromycin also inhibits P-glycoprotein, which increase plasma levels of digoxin, trazodon, sildenafil, omeprazol andglibenclamid. Clarithromycin and azithromycin prolong QT interval and can cause arrhythmia torsade de pointes, which can bepotentiated by other drugs with similar action, such as amiodarone, sotalol, haloperidol and others. The close cooperation betweenprescribing physicians, pharmacists and other specialists, (eg. clinical pharmacologist or pharmaceut) is highly recomended toreduce the drug interaction risk for patients.

Keywords: drug-drug interactions, macrolide antibiotics, statins, digoxin, calcium channel blockers, QT interval.

Published: July 1, 2017  Show citation

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Prokeš M, Suchopár O, Suchopár J. Macrolides Drug Interactions in 2017. Klin Farmakol Farm. 2017;31(2):7-13. doi: 10.36290/far.2017.010.
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