Klin Farmakol Farm. 2009;23(1):44-45

Acute pericarditis as an adverse effect of mesalazine

MUDr. Dominika Hajdu¹, František Šincl², MUDr. Ján Ürge², doc. MUDr. Vlastimil Procházka Ph.D³

¹ Ústav farmakologie LF UP a FN Olomouc

² II. interní klinika FN a LF UP Olomouc

³ II. interní klinika LF UP a FN Olomouc, endoskopické pracoviště

Pericarditis in patients with inflammatory bowel disease may appear as an extraintestinal manifestation or as an adverse effect of treatment.

37-year-old male with active ulcerative colitis was admitted to hospital with chest pain, fever and ECG changes in limb and precordial leads and

increased CRP plasma level. Three weeks before initation of complaint, treatment with mesalamine and methylprednisolone was started.

Ulcerative colitis was diagnosed by coloscopy and histology. Adverse effect of mesalamine treatment was suspected, mesalamine was

discontinued, dose of metylprednisolone was increased and azathioprine was added. Few days later chest pain and laboratory marks

of inflamation disapeared. This case was second epizode of pericarditis in this patient, the first one being 11 years ago. After withdrawal

of mesalamine the clinical signs of pericarditis disappeared too.

Keywords: drug adverse effects, acute pericarditis, mesalazine, ulcerative colitis.

Published: May 1, 2009  Show citation