Klin Farmakol Farm. 2009;23(1):42-43
Influence of cholesterol metabolizm by nitrogen - containing bisphosphonates
- II. interní klinika LF UK a Fakultní nemocnice, Hradec Králové
This review summarizes pieces of knowledge about the influence of nitrogen-containing bisphosphonates (N-BPs) on cholesterol
metabolizm. This issue has been studied just little so far. Ibandronate, pamidronate, zolendronate, risedronate and alendronate belong
to N-BPs. Their mechanism of action is the inhibition of pharnesylpyrophosphfate synthetase (or isopenthenyl transpherase), an enzyme
in cholesterol biosynthesis pathway. Owing to this ability, positive influence on lipidogram (lowering of serum cholesterol, LDL-cholesterol
and increase of HDL-cholesterol) has been demonstrated in the majority of clinical studies. There is not enough data about the influence of
N-BPs on brain cholesterol metabolizm. Even though N-BPs are primary indicated in therapy of bone disorders, their influence on cholesterol
synthesis is similar to statins and begs the question about their similar use in clinical praxis.
Keywords: bisphosphonates, cholesterol.
Published: May 1, 2009 Show citation
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