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FARMAKOLOGIE4546804001074292139211266312373415475534555598
A51618040010753
FARMACIE5231804001074291138211265317337380
12356558020012657110167
PŘEHLEDOVÉ4549200012660124182256312369444520587645
ČLÁNKY5216200012660115187259327395
Inhibitory30203600106155697115150168200239275311
protonové334736001063368109139178220260298330
pumpy:369236001063374127162199212
racionální391936001063475109126167208248279321338
preskripce427336001063368100135170206224258293325
a4614360010638
dlouhodobá466836001063768107149190230270311348388
bezpečnost507136001063466101136167202244284317350
u5437360010638
dětí549136001063869103121
Praktická343590014767108168228273302356416477
doporučení845590014770137206274316384437497566596
pro1465590014771113180
optimalizaci343730014768137179208309370400429482544597627
farmakoterapie99573001473899140241302362427469529571631701731792
PPI1812730014767132161
vzhledem343870014761115182211271340400501
k866870014761
bezpečnosti950870014770131183252313365432498546587615
(7,15868700143328588
8,169387001435875
9,178787001435970
10)1876870014359106131
1.343104001094862
U4831040010960
pacientů571104001095399141164211264295347
s9451040010937
nedostatečnou1010104001095199153205243275322353399443495547599
odpovědí16371040010951105158211256302356379
na483118001095197
léčbu:611118001092270114167220240
zvážit882118001094088134176199230
genotypizaci1144118001095299152205236284339362403450493515
CYP2C1916901180010951102149193244288328
a4831320010945
eventuálně555132001094792138191222274319342394442
zvážit1024132001094088134175198229
podávání12811320010953106160205249295347370
rabeprazolu1678132001093177130179233264310483146001093988110160
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postup,10271460010951102138169218270288
nejméně1336146001095096118193239290335
ovlivněn1693146001094992114135179230275326
polymorfismem).4831600010951102124167243293323352376412487532608631648
2.343174001094866
U4831740010960
pacientů571174001095399142164212264295347
se946174001093785
známým1059174001094092138216259338
PM14251740010950123
fenotypem1577174001092774127179210258312361439
CYP2C194831880010951102150195246290332
zvážit854188001094089136178201234
snížení1127188001093790113155203257280
dávky,1446188001095399144190239255
zvláště1741188001094089113159197230278
u4832020010950
pantoprazolu,553202001095195145175224275305349389438460510529
který1102202001094275119149195
je1317202001092267
nejvíce1404202001095096118162184224269
ovlivněn1693202001094992114135179230275326
při483216001095181103
polymorfismu.6052160010951102124167243293323352376411486536555
3.343230001094664
U4832300010958
pacientů556230001095194135155200250279328
se899230001093580
známým995230001093888131205246321
ultrarychlým1331230001094970100129172201246286335356398473
fenotypem1820230001092671120170483244001092973124168242
CYP2C19:73724400109499513918022826830510442440010918
zvážit1077244001093882125163183212
zvýšení1304244001093882127161205254274
dávky1593244001095092133174219
nebo1826244001094994144193
podávání4832580010951102154197240284334355
dvakrát857258001095195139181212256286
denně.1162258001095196147197242260
4.343272001094665
Při48327200109487798
volbě605272001094493115166212
PPI841272001094895116
zohlednit981272001093988139160206258308329359
věk1364272001094488131
dětského1519272001095196127164206250301351
pacienta1894272001095196483286001094060105154183226
a7242860010943
s7822860010935
ním832286001094970143
související991286001093584133176197231276297317357377
změny13832860010938112157206247
v16452860010942
rychlosti1702286001092974113162182231266296317
metabolických4833000010975121151196247298320341382424469509559
a10613000010944
eliminačních112430000109456788163184234278319369390430480
procesů:1623300001095182131172217253302320
„229864005637
Novorozenci2378620010959110152201231281319364415455476
a2874620010943
kojenci293662001094391113159209250271
mladší322662001097697141192227248
jednoho349462001092267119169219270320
roku:237876001093082127180200
preferovat261076001095284132161209240292337384415
esomeprazol305776001094684137216264318350396438490513
(FDA,360276001092772134189212
EMA2378900010944117172
schváleno).257090001093576126168212234279330380403420
„2298106005637
Děti23781040010960105136157
ve2551104001094387
věku2654104001094388130180
1–112850104001094688129167
let:303310400109216697116
lansoprazol3165104001092165114150199251281325364413435
nebo3616104001095096147198
omeprazol23781180010949125171223253297336386408
(dobře2805118001092574124176206251
prostudováno).3075118001095181131166197247298348391435485535558575
„2298134005637
Dospívající23781320010960110145196217261304326347387408
děti2801132001095196126147
nad2964132001094993143
123123132001094686
let:322513200109216696115
kterýkoli3356132001094274119148194236285306327
PPI3699132001094894115
dle2378146001095172118
indikace.2515146001092171122144186231271316334
Nejčastější21381710014781142172224283331372431461509538
lékové2698171001473191151215272331
problémy30511710014770112177246275335436492
vznikající21381850014761115182211270330359388440468
při26291850014770111140
preskripci27911850014770111171220279321350418471499
PPI33131850014767131159
u34941850014769
dětí35851850014770130171199
Preskripce2278202001094875118153193222242292331374
PPI2670202001094893112
u28012020010949
dětí2869202001095094123142
je3029202001092266
často3113202001094183117146193
spojena3324202001093685134154198247288
s36312020010935
pochybeními,368520200109511002138216001094292134187234285306382404422
která2589216001094476122152196
mohou28142160010978128180230281
vést3124216001094590126157
k33102160010943
neefektivní3383216001095197144171217260293314358410431
léčbě,2138230001092267108158204221
zvýšenému2382230001094085131166211261306382431
riziku283623000109305189109151201
nežádoucích3060230001095196135179230280329370390430479
účinků3562230001095191111160202252
a21382440010943
zbytečným2193244001093887127158200239286325399
nákladům2603244001095091131152193241288361
(16,2976244001092565104121
32,3109244001094687104
33,3225244001094687103
34).3340244001094690112127
Tabulka3479244001094479128176195235277
537682440010946
shrnuje2138258001093582109156202222264
pět2413258001095194122
klíčových254625800109416280117163203246282329
oblastí2887258001094897116157189217236
lékových3134258001092164103149189232269315
problémů3461258001095077124172192234306353
při213827200109507796
preskripci2245272001095178120153192220239287326344
PPI2600272001094791109
v27212720010942
pediatrii2774272001095194143161201228255274292
a30782720010942
nabízí3132272001094989137156192211
praktická3354272001095178119158188206244283325
doporučení369027200109509621382860010951100128177216258307326
pro2479286001095180127
lékaře2621286001092165106149177220
a28562860010943
farmaceuty291428600109276997171213252294343371414
s33432860010936
cílem339428600109405981125198
racionalizovat36072860010930721111301782138300001095092111131168215256299326
terapii2480300001093073101143193212232
a27273000010944
zvýšit2786300001093983127161180209
bezpečnost3010300001095196134183228268316364398427
pacientů.3452300001095294133152196245272320337
Závěr3934590014768131190250294
PPI4074760010949101125
u4250760010952
dětí4353760010952102136161
by4565760010953100
měly4716760010977128153201
být496876001095399136
indikovány515676001092176132157204257305353408454
u3934900010950
GERD,4013900010959106156219237
vředové427990001094476123177229274320
choroby462790001094193145177229282327
gastroduodena,498290001095197134167198249303355407461509561607628
eozinofilní3934104001094698138160212264292317340392414
ezofagitidy4376104001094687138166212265287319342395439
a48431040010944
v49151040010944
rámci4987104001093075153195218
eradikace5233104001094577123176198242288331377
Helicobacter3934118001095699120142181228277325364395436466
pylori4423118001094888109157187209
a46561180010943
u47271180010949
hypersekrečních4803118001095093146193224262308352384430472523545587638
stavů.54681180010935671123934132001094599120
Farmakokinetika4090132001094588121201248294346392417471520554577623671
a47971320010944
farmakodynamika4877132001092775107187234280332388434489536615639685733
PPI3934146001094896117
u40721460010949
dětí4141146001095197129151
je4312146001092268
komplexní4400146001094392169221244291334386408
a48281460010944
dynamický4892146001095094146191267289331374420
proces.5332146001095283133175221258278
Dávkování39341600010961107151197248293339392415
musí43771600010977129166189
být4595160001095296131
pečlivě47551600010952101144167190236283
individualizováno50661600010922741281511972212743263723954184595113934174001094388139190
s41491740010936
ohledem42101740010950101124170223269346
na4581174001095095
věk,4701174001094389132154
hmotnost48811740010950126177208259309346378
a52841740010943
známé5353174001093890134210257
genetické3934188001095199152200232255297341388
predispozice4350188001095284132186209246299352392415458504
pacienta,4883188001095298141164211264295342362
aby5274188001094498142
byla5444188001095296120166
zajištěna3934202001093986109132168201247299344
optimální43062020010950104136158235281304355378
účinnost4712202001095092115167218270307340
a50802020010944
bezpečnost51512020010952100141195243286338389427459
léčby.3934216001092271115170216233
Délka42022160010962111136181229
podávání44662160010953107162209255302355379
je4880216001092271
závislá4986216001094088134158196220267
na5288216001095198
typu5421216001093179135189
indikace3934230001092274128151196243285332
a42952300010944
neměla4368230001095199178226249295
by4692230001095297
být4817230001095397132
samovolně4978230001093683161214259310334387435
prodlužována54412300010952851363934244001095173124163214258302353398
a43532440010943
měly44182440010975121144188
by4627244001095194
být4743244001095194128
použity48922440010951103154194216247293
co5206244001094190
nejnižší5317244001095097120171193232271293
efektivní3934258001094572118161194215259310332
dávky4283258001095194137180226
(16,4526258001092568110130
32).4673258001094690114132
Znalost4822258001094999143165215251282
možných51212580010975125163214255295346
nežádoucích54842580010949953934272001093884135186236278299340390
účinků4342272001094991112162205256
by4615272001095194
měla47262720010975121144188
patřit4931272001095196126156178209
k51572720010942
základním5216272001093984127151195246297318394
krokům3934286001094274125168219295
bezpečné4256286001095299139192239281332379
léčby4662286001092167110162205
léčivými4894286001092168110132177223300323
přípravky5243286001095282105157188233276320367
s39343000010936
obsahem39913000010949102138184235281358
PPI.4370300001094895117138
LITERATURA344323001234978134189250318368438498567
1.34334000853648
Dipasquale41134000834561100133159198236268284319
V,75034000833544
Cicala8143400083405587120135167
G,100134000834457
Spina10783400083337287125157
E,125534000833346
et132134000833456
al.13973400083324760
A1477340008341
Narrative15383400083447798120153174190222257
Review181434000833671103119154205
on34335000833775
Efficacy431350008333506886118151183216
and66035000833269108
Safety7813500083336584118141174
of96835000833756
Proton10373500083355693115151190
Pump123935000833572130169
Inhibitors14213500083155290105144160182219240267
in170135000831553
Children.17663500083407893108147168202239253
Front3433600083325289128149
Pharmacol.50836000833572104126184216249285301314
2022;13:839972.83836000833468101136148178208219254288321357389424436
2.34337000853652
Cheng40937000834078113151190
E,61437000833245
Zhang67437000833876108146185
X,87437000833851
Wilson9403700083577489115153192
KS,11463700083357083
et124437000833456
al.13153700083314760
JAK-STAT613903700083246499119150184222250283
Pathway16873700083356789127178211241
inhibitors1943370008315533433800083385392107130167188215
block5783800083395493125155
eotaxin-37533800083347294127159174212235267
secretion10393800083276294116150172187225264
by132238000833970
epithelial14113800083347489112150185200215247263
cells1693380008331658196122
and183438000833270109
fibroblasts1963380008317333433900083396097137153185212235263
from6193900083194178136
esophageal7693900083346199139177210249284315331
eosinophilia11143900083347299114152190230268283298313345
patients:14733900083397293109143182203231243
promising17303900083396098156171197212250289
agents34340000833271106144165193
to55040000832158
improve62240000831572111133170202236
inflammation872400008315537087119177235267289304342381
and126640000833270109
prevent13894000083396094126161199220
fibrosis1623400008317347394132158173199
in183640000831552
EoE.190240000833370104117
PLoS34341000833566104136
One.49441000834786121133
2016;11:e0157376.64241000833468100131143174201210244280312342375409441473487
3.34342000853651
Cheng41442000834078113152191
E,62542000833346
Zhang69242000833876108146186
X,89842000833952
Huo97142000834482120
X,111242000833851
et118442000833456
al.12614200083324760
Omeprazole1342420008347106141181202235265303319354
blocks17164200083395593126156185
eotaxin-31922420008334733434300083225689105145168202
expression56643000833568109131167194222238277317
by90543000833972
oesophageal99843000833875103143184224257298334367383
squamous140343000832667106139199239278306
cells17304300083326784100127
from18784300083194281141
patients3434400083407497113150189212241
with6064400083526892132
eosinophilic75944000833576104119159199240280296312328362
oesophagitis114244000833976104144185225259300316339356383
and154744000833272113
GORD.168244000834594132180192
Gut.189644000834585108123
2013;62:824-832.34345000833468100130141177211223258291323346382416449461
4.34346000853651
Kierkus4094600083355186107138176202
J,62646000832436
Oracz67746000834769102134165
G,85746000834357
Korczowski9294600083357294125155193244271301317
B,126146000833548
et132446000833456
al.13954600083324760
Comparative147046000834077135174207228261283298331365
safety18504600083265978113135169
and34347000833270109
efficacy466470008334537188120153186219
of69947000833857
proton7714700083386097119156194
pump98047000833877134174
inhibitors11684700083155391106145160183220241269
in145147000831553
paediatric151847000833972107146161193215237252284
gastroesophageal181747000833870971201411783434800083346199139177209248283315331
reflux689480008321557289127158
disease.8624800083385480115147173208220
Drug109848000834567105144
Saf.1257480008333668596
2014;37:309-316.136848000833569100131143178210220256290325349381412443457
5.34349000853650
Osefo40949000834774109128166
N,59149000834558
Ito6654900083153774
T,75549000833342
Jensen8134900083245998124159197
RT.10264900083367079
Gastric112149000834477103126148163195
acid13334900083326479118
hypersecretory146749000833868108144165192227260281315338374396430
states:19134900083275083343500008322568396
recent4595000083215689123161183
insights663500008315538095134172194222
and90650000833270110
advances.103650000833272105138177209243270284
Curr13415000083407799121
Gastroenterol148250000834477104128149187223262283317339377393
Rep.189550000833671111124
2009;11:433-441.34351000833468104140152182210219253286319340377414444454
6.34352000853651
Melek40652000835488103138167
J,58652000832435
Bělohlávková6345200083356984121159174206237267304335367
S,101452000833244
Látalová10715200083316385117132169201233
V,131652000833544
et137252000833456
al.14405200083314659
Doporučení151152000834583122160181219250283321335
Sekce18585200083336797127160
dětské3435300083387395123153187
gastroenterologie5435300083387097120142179214253274308329366382420460475510
a1066530008332
výživy11115300083326697112145179
České130353000834074101131165
pediatrické148153000833974114129161183204220252282316
společnosti18105300083276510412015518834354000833876103126141
pro5025400083386097
diagnostiku6175400083385385124162200227250265295333
a968540008332
léčbu10175400083155083122160
eozinofilní119454000833473101117155193211228243281296
ezofagitidy150754000833464101120154193208230246284316
u1841540008337
dětí.18965400083387395110123
Ces34355000834074101
Slov4595500083324886118
Pediat.59255000833569108123155177190
2024;79(Suppl.4):5-28.79855000833468101133145177211230262299338378394407441458470506528559592606
7.34356000853645
Ward40156000835789110148
RM,56356000833591104
Kearns68156000833569101122161187
GL.8825600083447690
Proton9865600083355593114151190
pump119056000833877134174
inhibitors13785600083145290105144160182219241268
in166056000831552
pediatrics:172656000833975114129161183204220252280292
mechanism34357000835791124161193230245271328
of68357000833756
action,7515700083326487102140178190
pharmacokinetics,95357000833977108129187219250287317333370405427442473500513
pharmacogenetics,147957000833876108128186218250286325359397431453468500527540
and34358000833270109
pharmacodynamics.46758000833977110131189222254291330362401433491506538566579
Paediatr106258000833567102141156188210232
Drugs.130958000834567105144170184
2013;15(2):119-131.150858000833468100130142172202219253271283313341371394425455486495
8.34359000853653
Litalien4165900083324770104119135170209
C,64559000834154
Théorêt72059000833373108148170204227
Y,96859000833544
Faure103359000833262101122157
C.121159000834053
Pharmacokinetics128559000833674107128188220253291322338377412435451483511
of181759000833858
proton1896590008339619834360000832262103
pump47860000834081142183
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SPC85162000833265105
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[cited646630008318486386120159
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2026-01-12].103366000833468101134158195226245276305323335
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online.lexi.com.3436700083377691106144179191207242274289302334371429442
11.3436800085376881
Zhang44568000833978112151192
Z,65868000833953
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W,94668000835969
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M,128668000835670
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pharmacokinetics34369000833977109131189221254291321338375410433448480508
of87069000833857
lansoprazole9476900083154785111149189211244273310326361
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Andersson43671000834077115149170196222259297
T,74571000833240
Hassall79771000834475101126159173188
E,99771000833244
Lundborg105371000833167104142181218239276
P,134171000833539
et139271000833355
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of34372000833757
orally4157200083375891107122154
administered58472000833170128143181196222246279301335374
omeprazole97372000833796131170192225254291307342
in133072000831553
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Tjon22353600083335088126
JA,23753600083246478
Pe246736000833568
M,254936000835468
Soscia26303600083337198130145177
J,282136000832436
et287136000833456
al.29413600083314760
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and324536000833169108
safety33673600083265978113135169
of354936000833857
proton36203600083386097119156194
pump213837000833977135174
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gastroesophageal35123700083387096120141178214241279213838000833977109149183215231
reflux2384380008321557289127158
disease.25573800083385480115147173208220
Pharmacotherapy.279338000833572104126184216249286307346381402435474505515
2013;33:956-971.332438000833468100130141176209220255290324347382415448457
14.21383900085366984
Tighe22383900083334988126161
M,241439000835568
Afzal24983900083415990124139
NA,265339000834485100
Bevan276839000833570103136174
A,295739000834155
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al.30993900083314760
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children2376400008331698499138160194232
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reflux.3353400008320547289126158171
Cochrane353940000834077110148169202240275
Database21384100083457899132171204231266
Syst24194100083336289113
Rev.254741000833570103112
2014;11:CD008550.267541000833468100131143173201209250296331368403437469504516
15.21384200085366882
van223342000833164102
der23474200083387293
Pol24534200083357187
RJ,25534200083356173
Smits263942000833289104126153
MJ,28054200083547991
van290942000833164101
Wijk30234200083577388117
MP,31534200083549094
et326042000833355
al.33284200083314759
Efficacy3400420008332506785117149181214
of362742000833756
proton-pump3695420008339609721384300083225997119159198256295
inhibitors24514300083155391106145161183220242269
in273943000831452
children2810430008331698499138160194232
with30604300083516789127
gastroesophageal32064300083387097120142179214241279319358390429464496511
reflux37364300083205421384400083173471102
disease:22524400083385379113145171206218
a2482440008332
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review.28374400083215586102136187197
Pediatrics.304744000833568107122154175196211243270284
2011;127:925-935.33434400083346899127135164194226236271304338360394427459471
16.21384500085367187
Rosen224645000833675102138177
R,244445000833650
Vandenplas251545000833769107147183222262278311338
Y,287445000833645
Singendonk29404500083334887126162201241280319350
M,331145000835569
et340145000833558
al.34804500083324861
Pediatric356245000833670110126159181203219252
gastroesophageal21384600083397299123145183220247287327367400440476508524
reflux2684460008321567491129162
clinical28674600083324763102117150184200
practice30884600083396295128153169202237
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joint36834600083155470109131
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the27464700083226095
North285447000834583105130168
American303547000834199134155171203236274
Society332247000833371104119154176210
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Pediatric3636470008335691081231552138480008321435890
Gastroenterology,224048000834476102125146183218256277311332369384422461493502
Hepatology,275548000834479117150172208224261301332342
and311048000833169107
Nutrition323048000834482104125141163178215254
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the36174800083215994
European37234800083336921384900083215897133165203
Society235849000833371104119154176210
for25854900083185678
Pediatric268049000833568108123155177198214246
Gastroenterology,294349000834477103126148185221259280314335372388426466498508
Hepatology,346849000834479119152173210226264304336346
and213850000833270109
Nutrition.226150000834583105127143165180218257270
J2546500008324
Pediatr258450000833569108124156177199
Gastroenterol279750000834477103127148185221259280314335373389
Nutr.320050000834583105127137
2018;66:516-554.335250000833468100131143179214227262293324348382414449462
17.21385100085366776
Gieruszczak-Białek22275100083435993114152178207238269302332352388404435451486516
D,275551000834556
Konarska282451000833572110142163190219252
Z,308951000833851
Skórka31525100083336299121151184
A,334951000834155
et341651000833456
al.34855100083314659
No355751000834482
effect36525100083345372106138162
of213852000833756
proton22065200083396097118155193
pump241152000833976134172
inhibitors25965200083145289104143158180216238264
on287352000833775
crying29605200083315286101139177
and315052000833169107
irritability327052000831435577294126165180195210232265
in354852000831452
infants:36125200083155271104141162190202
systematic21385300083265986109143200233255270302
review24565300083215587103137189
of266153000833756
randomized27345300083205391130168227242271305344
controlled309553000833168106128149186202217252292
trials.3403530008322435991106132146
J3565530008324
Pediatr.360553000833569108123155177199209
2015;166(3):767-770.213854000833468100130141171202238257290308319353385418436467502535548
18.21385500085377390
Gottrand226155000834586110136160195236277
F.257155000833341
Acid26455500083427592134
peptic281155000834078120144161195
disease.30395500083395684121156184222235
In:33075500083155669
Kleinman34095500083365492109149210244285
RE,37265500083377388
Goulet213856000834482120135170192
O-J,23435600083477192104
Mieli-Vergani246056000835469104119134156192225246284316354369
G,284256000834357
et291156000833457
al.,2980560008332476073
eds.30665600083347399113
Walker’s319156000835889104134168189203228
Pediatric343256000833569108123155176198213245
Gastrointestinal3690560008344761032138570008322438096134155189216239254292324340
Disease.24925700083456187122154180215227
Hamilton:273457000834476134149164187224262274
BC302257000833676
Decker311257000834681114144178199
Inc;3325570008315538598
2008:152-164.343757000833569105140153182212246266297328364377
19.21385800085366982
Homan223558000834482141173211
M,246058000835568
Jones254258000832462101136163
NL,27195800083447690
Bontems282358000833574112134168225252
P,308958000833539
et314258000833457
al.32135800083314760
Updated328758000834482122154176210249
joint35505800083155369107128
ESPGHAN/NASPGHAN369258000833367101213859000834387127172197242282315349393437477521
guidelines26725900083377489127161176190227262288
for29725900083185576
management306059000835788126157195229286320358379
of345159000833755
Helicobacter3519590008343779210713817421324527721386000083225577
pylori22326000083386986124145161
infection24106000083145271106138162178216254
in268160000831553
children2751600008331698499138159193231
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adolescents312560000833271109125160187219253291312340
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J3681600008324
Pediatr37226000083356921386100083385385107128
Gastroenterol228261000834376103126147185220258280313335372388
Nutr.268561000834583105127137
2024;79(3):758-785.283761000833468101133145178211230264281293326359393416447481515527
20.21386200085367287
IPLP22456200083155081117
receptář.23826200083215588121160183215236245
[Internet].2647620008319347294128149188223245262274
Institut29416200083155379102118140178201
postgraduálního316262000833877104127165186219258295328343381396435474
vzdělávání36566200083316210013521386300083154880114153168
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[cited2830630008318496588122163
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from:36626300083194280139152
https://iplprecept.cz/about.21386400083385983123150162189209225264280319341375408441481503516548579607637676715753776789
21.21386500085367082
ČOSKF.223365000834085118152186193
Pracovní24396500083355689121158190228244
skupina26966500083265694133148186219
pro29286500083386097
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léčiv3254650008314498297129
sondou339665000832665103142180218
ČOSKF362765000834086118153187
ČLS213866000834173109
JEP.22686600083255996101
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[Internet].2828660008319357497131153193229252271283
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klinické22866700083304762101116149179214
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[cited3008670008318496487122162
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Available355367000834172106121137169209225261
from:21386800083184179138150
https://www.coskf.cz/pracovni-skupina-pro-podani-2309680008338598412415116419121226331737138241545247950953154357560663467269472876079783086988490793496410031043105810971129115211931215125212761316135613961428146714821505
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22.21387000085367389
Cohen224870000834077116152190
S,245970000833245
Bueno252570000833574109147186
de273170000833974
Mesquita282670000835490117156194209232265
M,311270000835568
Mimouni320170000835570128167205244259
FB.34817000083326881
Adverse358370000834179112147168196231
effects21387100083345473108141166194
reported23537100083205595134156181215255
in262971000831553
the27037100083226196
use28207100083376499
of294071000833857
gastroesophageal30187100083397198122144181217245283323362395435470502518
reflux3557710008321557390128160
disease37387100083385321387200083266193120155
treatments23107200083224377109131189224262284312
in263972000831553
children:27097200083327085100139160194232244
a2971720008332
10302072000833566
years31047200083316597118145
literature3267720008315305286107140162200221255
review.35407200083205587103137188199
Br375772000833557
J3934340008324
Clin39733400083405671108
Pharmacol.409734000833572105126184217249286302314
2015;80:200-208.442734000833468100130141176211224259293330353384419454467
23.39343500085367287
Laurini404135000833165102124139177192
GS,42523500083447790
Nikitina43603500083456090107129144182215
V,459435000833544
Montanaro465735000835493131153186224256277314
N,499035000834558
et506735000833456
al.51423500083324760
Safety52213500083326584119141175
of541435000833857
proton5490350008339609739343600083225997
pump404936000833977135174
inhibitor42413600083155391106145161183220242
in450136000831452
paediatrics:457136000833972107147162194215237252284312325
a4914360008332
study49643600083264987126158
based51403600083397298133173
on533136000833776
EudraVigilance54253600083336910812916239343700083365291106121153191224257
data.42073700083387092125138
Fundam436037000833369107146178236
Clin46113700083405570108
Pharmacol.473537000833572104126184216249285301314
2025;39(4):e70036.506537000833468101136146181215234267284296330363396432465500513
24.39343800085367186
Orel404138000834769103118
R,418038000833549
Benninga424938000833671109147162200239271
MA.454138000835496111
Drugs467238000834567105144170
in486338000831452
Focus:493538000833370103141167179
Proton51353800083355693115152190
Pump534538000833573130170
Inhibitors.55353800083155339343900083385392107130167188215229
J4178390008325
Pediatr421839000833568108123155177198
Gastroenterol443239000834376103126147184220258280313335372388
Nutr.483539000834583105127137
2021;72(5):645-653.498739000833468101133141174208226259277289325361394416453487520533
25.39344000085367083
Naito40274000083447588109144
Y,418040000833542
Kashiwagi42314000083356791127140190220257271
K,451240000833447
Takagi45694000083325886118155168
T,474740000833239
et479640000833454
al.48604000083314556
Intestinal49264000083145070102127148162198228242
dysbiosis51774000083386893130144180205218242
secondary5429400008326598912416139344100083386989121
to406841000832157
proton-pump41374100083395995116151188209248285341379
inhibitor45284100083155188102139154175210230
use.47714100083376296106
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2018;97:195-204.51794100083346797127138172203212240269302323352385420431
26.39344200085367187
Lassalle40354200083316591118151166182216
M,426542000835467
Zureik43464200083377495129144174
M,453342000835568
Dray-Spira461442000834667100131153185223239260293
R.492042000833550
Proton49834200083355693115152190
Pump518742000833572130169
Inhibitor53694200083155391106145161183220241
Use393443000834469104
and405643000833270109
Risk41834300083355177107
of430743000833857
Serious43824300083326788104142180206
Infections46064300083155372106139163178216255281
in490543000831452
Young497543000833569107145184
Children.51774300083407893108147168202240253
JAMA544843000832464120162
Pediatr.393444000833569108123155177198209
2023;177(10):1028-1038.415844000833468101136147178207241258290321339351381413445479502533564597632645
27.39344500085367079
Freedberg40264500083325185120159198233254291
DE,43304500083457891
Haynes443345000834476106145179206
K,465145000833549
Denburg471345000834580117156194215252
MR,497845000835489103
et509445000833355
al.51624500083314659
Use523445000834368103
of534945000833756
proton54184500083385996118154192
pump393446000833977134173
inhibitors41204600083155290105144160182219240267
is440046000831541
associated44534600083325985123156171203224258297
with47634600083506688126
fractures49024600083184073105129167188222249
in516346000831553
young522946000833068106144182
adults:542446000833271108124146173186
a3934470008331
population-based397847000833876115152167198220234272309331370403429463502
study.44924700083264886124155165
Osteoporos46694700083467395128166205243264301327
Int.5008470008315527386
2015;26:2501-2507.51064700083346798128138172205217252286319350368399433466498504
28.39344800085367288
Malchodi403848000835487102134172211250265
L,431948000833145
Wagner437948000835789128166201222
K,461648000833550
Susi46814800083337096111
A,480748000834156
et487848000833456
al.49494800083324860
Early50254800083326586102134
Acid51744800083417388127
Suppression531648000833270109149170204231258272393449000833776
Therapy402649000833271106128161200231
Exposure427349000833265104143170207228262
and455149000833270109
Fracture46764900083325285117141179200234
in492649000831553
Young499549000833569107145184
Children.51954900083407893108147168202240253
Pediatrics.5464490008335691081233934500008332547591123150164
2019;144:e20182625.411350000833468100130143173204241253288322356388419453486520555567
29.39345100085377488
Wang404351000835891130170
YH,42345100083368295
Wintzell435151000835875114136167202219234
V,460651000833746
Ludvigsson467351000833270110144160200227254293333
JF,50275100083245865
et511351000833558
al.51925100083324861
Association52755100083417097137170186219241257296335
Between39345200083357193146180216254
Proton42055200083355693115152191
Pump441352000833572130169
Inhibitor46005200083155291106145160183220241
Use485952000834369104
and498152000833169108
Risk51075200083355177107
of523152000833757
Fracture53055200083325285117141179201235
in555752000831553
Children.39345300083407893108147168202240253
JAMA420353000832464119161
Pediatr.438053000833568108123155177198209
2020;174(6):543-551.460453000833468101135148178207238257291309321356391424446480512543552
30.39345400085367287
Mitre40385400083547092114148
E,420254000833346
Susi42645400083327096111
A,439154000834155
Kropp44625400083355895134174
LE,46525400083326578
et474654000833456
al.48185400083324861
Association48955400083416995133166181213235250288327
between52385400083387496149184219257
use55115400083386499
of393455000833757
acid-suppressive40115500083326479118140167205244283305339366393408440474
medications450655000835792132147179212234249287326352
and487855000833270109
antibiotics50085500083327091107146161199221237269296
during53255500083387597112150189
infancy55355500083145239345600083185290123156
and411156000833270109
allergic4241560008332476298119157173205
diseases44665600083385480115147174209236
in472356000831553
early47965600083346688104136
childhood.49525600083327085100139178216255295308
JAMA528156000832464120162
Pediatr.5464560008335691081243934570008332547585
2018;172:e180315.403557000833468100131143173202237249284313344380413444474486
31.39345800085366981
Al-Aly40305800083415679120135167
Z,421158000833851
Maddukuri427758000835487126165202232271292307
G,459958000834357
Xie46705800083385388
Y.477258000833544
Proton48305800083355693115152191
Pump503558000833572130169
Inhibitors52185800083155391106145161183220242269
and550158000833270109
the39345900083215994
Kidney:40405900083355189127161192205
Implications425859000831572110126141172204226241278316342
of461359000833755
Current46815900083407696118151189210
Evidence49045900083326379117151189221254
for51705900083195677
Clinical52595900083405569107122153186201
Practice5472590008335558811939346000083223769103
and405860000833270110
When418860000835897132171
and437960000833271110
How451060000834483134
to466560000832159
Deprescribe.474460000834682121143177204237258274313349362
Am5126600008341100
J5246600008325
Kidney52916000083355291130165197
Dis.55086000083466188102
2020;75(4):497-507.393461000833468101135148181214231264282294328361394413447481513520
32.39346200085367187
Calabrese40416200083407388120160181215242277
F,433962000833238
Pasta43976200083366794117150
A,456762000834155
Bertin46436200083357092116132170
L,483362000833145
et489862000833457
al.49756200083324760
Updated505662000834382122154176210249
treatment53266200083214377109131189224262284
options393463000833880103119159199227
for41846300083195881
gastroesophageal428963000833973101125148187224252292333374407448485518535
reflux4847630008321577693132165
disease50356300083395683120153181218
in527663000831555
children:53546300083327288104145167203243256
practical39346400083406296129154170203237253
guide42096400083397894134170
for44006400083195880
clinicians.45026400083324863102118151167200239266281
Expert480464000833467108145167192
Opin501864000834889105144
Pharmacother.518464000833674108130190223257295317357393415426
2025;26(16):1631-1648.393465000833468101136147182215234266297315327357388422453471502533570606619
33.39346600085367186
Joret-Descout40386600083246284118140160207242269302338377399
P,445566000833539
Dauger451266000834577115154189210
S,473966000833346
Bellaiche48026600083357086101133149180218253
M,507366000835468
et515866000833456
al.52326600083324760
Guidelines53096600083448297136171187202240275301
for39346700083185678
proton40286700083396097119156195
pump423967000833977135174
inhibitor44296700083155391106145160183220241
prescriptions46876700083386094121153174190229251266304343369
in507267000831553
paediatric514167000833972107146162194215237252284
intensive5442670008314527410714639346800083264174108
care40576800083316485119
unit.41926800083377590112126
Int43336800083155374
J4423680008324
Clin44626800083405570108
Pharm.458568000833673105126185198
2017;39(1):181-186.479868000833569101130140175208227259273285315346378397427458494507
34.39346900085357287
Tezel40336900083326291124140
Yalçın41856900083356378110124161
H,435969000834355
Yalçın44276900083356378110124161
N,460069000834457
Allegaert46696900083415670104143175209230254
K.493569000833449
Real-World499669000833570101116137194230251266304
Safety53136900083326482116138171
Profile549669000833555913934700008317344984
of403770000833756
Proton41127000083355693115152190
Pump432170000833573130170
Inhibitors45097000083155391106145161183220242269
in479770000831553
Infants48687000083155372105143165193
as508070000833158
Reported515770000833570109148170194228268
in544470000831452
the55157000083226095
FDA393471000833277116
Adverse406271000834179111145166193227
Event43027100083326397135156
Reporting447171000833569108146168192207244283
System47667100083336289112145202
(FAERS):49817100083185088120155189207219
Tiny52137100083324886116
Tummies,534271000833265122179194228255268
Key393472000833569101
Decisions.405072000834581113128155169207246272286
Pharmaceuticals435172000833573105126185217249283320343358390423439465
(Basel).48317200083185487114149164184195
2025;18(5):730.504172000833468101136147177208227261279291324358393405