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KLINICKÁ341804001074588109168189242288347
FARMAKOLOGIE709804001074291138211265312372415474533554598
A13288040010753
FARMACIE1403804001074191138210265316336380
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Klin190680400107446583131
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Farm.2402804001074178104179195
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PŘEHLEDOVÉ341200012660124182256312369444520587645
ČLÁNKY1008200012660115187259327395
Inhibitory3413600106155697115150168200239275311
protonové66836001063368109139178220260298330
pumpy:101336001063374127162199212
racionální124036001063475109126167208248279321338
preskripce159436001063368100135170206224258293325
a1935360010638
dlouhodobá198936001063768107149190230270311348388
bezpečnost239236001063466101136167202244284317350
u2758360010638
dětí281236001063869103121
Inhibitory3409200298682083474105526167028399281058
protonové144792002981432333704575947338699911112
pumpy:26089200298143282487628749810
racionální34669200298922153213865236617868509891053
preskripce340118002981442333594625916847478889961119
a150811800298127
dlouhodobá168311800298143207344483622759901103811791305
bezpečnost303611800298144270381525651759899103611371224
u430811800298140
dětí449711800298143268356422
Jana3401580013745103167225
Tomanová1,5871580013761117211270334397454512109215900803611261580013729
Petra11771580013764120161204261
Rozsívalová2,14601580013766129180229259318376406469526584204315900803654
3,211015900803621471580013729
Rita2198158001376596136195
Halašová1,24151580013776134164223270334391449285615900803628901580013729
Josef29411580013745109156214252
Malý3,32161580013793152182239345415900803634911580013729
Jan35421580013745103167
Melek1373115800137931521832413014031159008036
1Dětská3401740078333711740013373128165209260313
klinika,708174001335178103163188239293315
Fakultní10471740013353102152213238274334359
nemocnice14301740013361116207268317378402451504
Hradec19581740013372107160222277327
Králové,2308174001336097150175235286340361
Lékařská26931740013352106157211246290341394
fakulta3111174001333285136197222258311
v34451740013353
Hradci35221740013371107160222271296
Králové,3841174001336097149175235286340361
Univerzita42261740013371131156208262298346372408461
Karlova47101740013360114149174235286339
2Oddělení3401890078333731890013376139200255281336397422
klinické818189001335279103164189237288341
farmacie,1183189001333285120212265313338393414
Nemocniční16211890013372127219279329389414463523548
lékárna,2192189001332681132186221282335357
Fakultní25731890013353102152213238274334359
nemocnice29561890013361116207268317378402451505
Hradec34841890013372107160222277327
Králové3834189001336097150175235286340
3Katedra3402040078333742040013360113149202265300353
sociální7512040013343103153178230255315340
a11152040013353
klinické1191204001335279103164189237288341
farmacie,1556204001333285120212265313338393414
Farmaceutická19942040013353102137228281330383444480504553604657
fakulta2675204001333285136197222258311
v30092040013353
Hradci30862040013371107160222271296
Králové,3405204001336097149175235286340361
Univerzita37902040013371131156208262298346372408461
Karlova42742040013360114149174235286339
Inhibitory340250001212478132154210232264317349398
protonové754250001215789142174226281335381429
pumpy11992500012157111193248294
(PPI)1509250001212879130151177
patří17022500012157105136167190
mezi19082500012183132174197
nejčastěji21212500012155104127171218256289337359381
předepisovaná2518250001215789137193243299321359413459506560607
léčiva3141250001212373117139186233
v33902500012148
pediatrii,34542500012157107163185232263294317339358
přičemž340264001215687109152199280322
jejich67726400121247294116159212
preskripce904264001215688136173218250272327371418
v13372640012148
posledních14002640012156110147169218273326348391444
letech1859264001212371103151194248
výrazně2122264001214796128174216270318
narůstá.24552640012155101132185222254301321
Ačkoliv27912640012161102147199221242289
jsou3095264001212461114168
účinné3278264001215497119172225274
v35672640012147
indikacích,3629264001212477132153340278001214795139161204258278
jako634278001212471117169
je819278001212574
onemocnění9092780012155109159241295340394443498520
z14452780012143
gastroezofageálního15042780012156103141173205258308350404432480535584631654708730786840
refluxu,2360278001213381110135189235289309
peptické26852780012157107163195217261306354
vředy3055278001214880129185232
či3303278001214466
eozinofilní33852780012150105146168222276304329352406428
ezofagitida,340292001215092145172220274296327349404450470
přetrvávají825292001215788136168199249296341388410432
obavy12722920012155110158202251
ohledně15392920012154109131179235289337
jejich189229200121247395117160214
bezpečnosti,21212920012157106148203253297350404441474495515
dávkování26512920012156102147193245291338391413
a30802920012147
častého3143292001214491129161209263316
off-label3475292001215482113141164211266315338
užití,340306001215598120153175195
zejména561306001214393116199249304351
u9393060012155
kojenců10213060012147100123173228273327
a13743060012149
novorozenců.14493060012156111157211243297338388443487541561
Tento2036306001215094149180234
článek2296306001214668115170220266
poskytuje25893060012157113151197247283337360410
komplexní30253060012147101184240264313360415438
přehled3489306001215790139194217267323
farmakologických340320001212976107189235280332355408463485528572621663716
vlastností1072320001214770116153186239292330362384
PPI14713200012153103124
v16103200012148
dětské16733200012156104136175220267
populaci19553200012157111166220242288331352
se2323320001213988
zaměřením2426320001214290171220250298352374455
na28963200012155101
specifika3013320001213994143187208236261306353
farmakokinetiky33813200012129771071892362813323784013403340012155104136158203252
a6073340012148
farmakodynamiky671334001212977108190236282334390436491537619641686735
v14213340012148
různých1484334001213387128182226269322
věkových1822334001214895141193239288331384
skupinách.2222334001213984138193215269316359413433
Zohledňuje26703340012155108162184233289342395418467
vliv315233400121487192139
genetického33073340012155104159208240261305350397451505
polymorfismu3403480012157112135182265319352383408446528582
CYP2C199483480012156108157202255300341
na13163480012156103
metabolismus14453480012184133166214270325348370408490544582
a20533480012148
klinickou212834800121477193147169213259312366
odpověď.25203480012155112167223269317374393
Dále29393480012167114136186
shrnuje3151348001213994125180234257306
aktuální3483348001214995129183231253307329
doporučení3403620012156110167222253308352400454476
pro837362001215789142
indikace,999362001212478134156201249293341360
dávkování13793620012157104149196248295342396418
a18183620012148
dostupné18863620012156110149181235291346395
lékové2302362001212372119171218266
formy.2588362001212983115198242258
Zmiňuje28663620012155137159213267290339
také3225362001213381127175
vhodnost34203620012148103157213268322360393
zohlednění340376001214396151173223279333382436458
věku814376001214896142196
dětského10263760012157106138177223271325379
pacienta14213760012157105148170219274305353
a17903760012148
s18543760012139
tím1909376001213355137
související2062376001214094148195218256305328350393415
změny24933760012143125175229273
v27823760012148
rychlosti2846376001213382125179201255293326348
metabolických32103760012183133165213268323346368412457506549603
a3403900012148
eliminačních40939000121507395177199253300344398420464518
procesů.947390001215789143187235274327346
Zvláštní13143900012155100123170208240295317
pozornost16513900012157112153206238293347385418
je2090390001212473
věnována2184390001214896150204250298352399
dlouhodobé2603390001215779133188242296352406463513
bezpečnosti31363900012157107149205255300354408446479501
a36583900012148
rizikům3726390001213356340404001214365111165247
spojeným610404001214095150173222277322405
s10384040012140
léčbou,1101404001212473118173228282302
jako1426404001212571117170
jsou1619404001212462117171
infekce,1813404001212478106155201244292311
fraktury2147404001212962109155190244275324
či2495404001214566
alergie.2585404001214870120151206228277297
Mezi29054040012180130172195
nejčastější31234040012156105128172219257290338361399421
chyby3567404001214599144200245
v3404180012147
preskripci402418001215687134172216248269324367388
patří8054180012155102132163184
neindikované10044180012154103124177231252297348393439492540
podávání15584180012156110165210254301353375
PPI19474180012152102123
v20844180012147
léčbě2146418001212371115168217
fyziologického2378418001212977120141194216269323344387431477531583
refluxu,2976418001213279107132184229282300
neadekvátně32914180012155103148203251295344390421474522
dlouhé340432001215577130183236284
podávání6384320012156110165211255301354375
léčiva1028432001212371114135181228
či1270432001214465
nevhodná13504320012155103148202254309362408
léková1772432001212472117168213259
forma.2046432001212981112193239258
Cílem2319432001215778101149230
je2563432001212472
podpořit26504320012156110164219272303324356
racionální3020432001213279121142195248294316368389
preskripci3424432001215687135172216248270324368389
PPI,3404460012153104126146
optimalizovat5054460012155111143165247294317339381434480528559
léčbu1084446001212373117173227
a13304460012148
minimalizovat13984460012183105160182264311333355397451497544576
rizika199344600121335597119165213
pro2225446001215789143
dětské23874460012156106138177223271
pacienty.26774460012157105149170220274306355370
Klíčová340462001246189116161218269322
slova:678462001244371128180232257
inhibitory953463001212378132155211234267320353402
protonové1373463001215689142175228283338384433
pumpy,18234630012157111194250296311
pediatrie,21524630012156107163186233265297320370390
bezpečnost,25594630012156107150206256301356410449482503
nežádoucí30794630012156105148197253307362407429
účinky,3525463001215599122176223272288
racionální340477001213381126149204260308331386409
preskripce.770477001215790140180226260284340386435455
Proton340502001245896154191249308
pump6695020012459118205265
inhibitors:954502001242886145173233261298356394439464
rational1439502001243890127155213272325353
prescribing1812502001246098152196242280308368396455513
and23465020012452111171
long-term2537502001242886145204237274327366452
safety3010502001244397131184222277
in3307502001242786
children34135020012445105132160220259312372
Proton340519001215385140173228284
pump6525190012157113197254
inhibitors934519001212480135158215239273327360401
(PPIs)1363519001212981133156196221
are1612519001214981131
among17725190012148132187243300
the2100519001213489140
most22685190012184140179213
commonly2510519001214599183266322378402449
prescribed2988519001215790140180225258282339390448
drugs3465519001215689145201240
in3734519001212379
paediatrics,3405330012156105154211234281313345368412453473
with831533001217396129183
their1032533001213387137160192
prescription1242533001215689138177221253276332365388442497
rates1757533001213280112161200
having19745330012155103149172227282
significantly2274533001213961117172194223249293341396428450497
increased2789533001212378122154203251289339396
in3202533001212378
recent3297533001213382127176231263
years.3577533001214796143175215236
Although340547001216185118174229285341397
effective766547001215080113163209245268317366
for1161547001212984117
indications1307547001212479136159204253286309365421460
such1795547001214095140196
as2019547001214988
gastroesophageal21355470012157105144178211266317357413470526575631682730754
reflux2917547001213383113140195242
disease,3188547001215780119170218258308328
peptic35455470012157109166199223268
ulcers,340561001215579124173206246268
or636561001215588
eosinophilic7525610012151106146169224280337393416439462507
esophagitis,1288561001215089145202258306363386419442481502
concerns1819561001214598154199249282338376
remain2224561001213382166215238293
regarding2545561001213383140188221277300356412
their2985561001213489140163196
safety,3209561001214089118168202252268
dosing,35055610012157112152175230286307
and3405750012148103160
frequent525575001212963113170225275330363
off-label913575001215584116146171218275326350
use,1288575001215594145165
especially1478575001215089146197243266314337360407
in1910575001212479
infants2014575001212479108157212244285
and23245750012148103160
newborns.25095750012155106179236292325381420441
This29755750012150106129168
article3168575001214880116139184207258
provides3451575001215789144191215272322361
a3405890012148
comprehensive407589001214598182239272321377428483522545593642
overview10685890012155102151184235259309383
of1469589001215584
the1572589001213388139
pharmacological17295890012157113161194277325370424448503560583628676700
properties2447589001215790145202253286322345395435
of2900589001215584
PPIs30035890012153105128167
in3188589001212479
the3286589001213388138
pediatric34435890012157108165189236269301325370
population,3406030012157113170225249297329352407463484
focusing850603001213085130185224247302358
on12356030012155111
the1372603001213388139
specifics1538603001213996147193215245271316356
of1921603001215584
pharmacokinetics20326030012157112160193277325370423471495551601635658702743
and28026030012148103160
pharmacodynamics29886030012157113161194277325370424481529585633716739784825
in340617001212379
different437617001215680109141192225274330362
age8186170012148104154
groups.991617001215688143198255294316
It1325617001212457
considers1400617001214599154193216273323356396
the1814617001213489139
influence1972617001212378107133188239294339388
of2379617001215484
CYP2C1924816170012158114168217274322367
genetic28666170012156107162213246269314
polymorphism31986170012157113137185269324357414470493532615
on3406310012155110
metabolism4676310012183133166215271326350373411493
and9786310012148102158
clinical115463100121446790145167212260283
response.1454631001213382121177232288326376396
Furthermore,18676310012149101133168223273305388443476525545
it2429631001212356
summarizes2503631001213993175258306338361403453492
current3012631001214599131164213268300
recommendations33306310012132821271802633453954513406450012156104137160215271309
for669645001212984117
indications,805645001212479136159203252285308363418457478
dosing,13036450012156111150173229285305
and16286450012148103160
available1807645001214995144167190238295319369
drug2196645001215689144200
forms.2416645001212984117200239261
It2696645001212457
also2772645001214972111166
mentions29576450012184134190222245300356395
the3371645001213389139
appropriateness35296450012149105162195250340659001215790113161194243299349389428
of789659001215584
taking894659001213382129154209265
into1180659001212479111165
account1367659001214893136190245301333
the1721659001213388139
age18816590012148104155
of2057659001215584
the2162659001213389139
pediatric23226590012157108166189237269302325370
patient27136590012157106138161212267300
and30346590012148103160
the3215659001213389139
associated3375659001214888127182227250298331380437
changes340673001214498145199255304343
in700673001212377
the794673001213387136
rate947673001213280112160
of1124673001215483
metabolic12246730012182132164212268323346368412
and16536730012148102158
elimination182867300121497295176199253300332354408463
processes.2308673001215688142187235273312361400420
Special27456730012149104155199222269291
attention3053673001214880114162217249271325380
is3450673001212361
paid35286730012156104126182
to3727673001213285
long-term340687001212378133189220253301334417
safety774687001214088117166199248
and10406870012148102158
the1216687001213387137
risks137168700121325593139181
associated1570687001214786125179224247294326375431
with2019687001217396129183
treatment,2220687001213365114161193276326381413434
such2671687001213993138192
as2880687001214887
infections,2984687001212478107156201236259313368407427
fractures,3429687001212962110154189243275324363384
or340701001215485
allergies.44170100121477092140172226248296334354
Among8117010012160141195248303
the1130701001213285134
most12807010012182135173205
common1501701001214496177258312366
prescribing1882701001215688136174217249271326348402456
errors2354701001214980112165196235
are2605701001214778127
the2747701001213386135
unindicated28987010012154107129183237259302349381428484
use3397701001215492141
of3554701001215381
PPIs36517010012152102124161
in340715001212379
the439715001213388139
treatment598715001213366116164196279330386418
of1036715001215584
physiological11417150012157112158198220275299355411434479528551
reflux,1713715001213282112138193240262
excessively1996715001215097141190229268291339388412460
prolonged2476715001215790145169224280336386443
administration29407150012148105188211266289328362394443475499553609
of3570715001215584
the3674715001213388139
drug,340729001215688143199219
and5777290012148103159
the753729001213388138
use908729001215594144
of1069729001215584
an11707290012148103
inappropriate1291729001212378125181238271325381414437485517566
dosage18747290012156111150199254304
form.2196729001212983116199220
The24337290012150106156
aim2606729001214871154
is2777729001212362
to2856729001213387
promote2960729001215789144227281314363
the3340729001213388138
rational3495729001213381113136190246293316
prescription340743001215790140179224257280337370393448504
of865743001215584
PPIs,9707430012153105128167188
optimize11797430012155112145168251275317367
treatment,1568743001213365115163196279329385417438
and20287430012148103160
minimize22097430012183107162185268291334384
risks261474300121335695142184
for2819743001212984117
paediatric29587430012156105156213236284316349372417
patients.33967430012157106138162212267300340362
Key3407600012463115168
words:5377600012477135175237282309
proton876760001215892148182238295
pump12007600012158115201259
inhibitors,1488760001212481138162220245279334368410432
paediatrics,19497600012158108160219243292326359384430472494
safety,2472760001214191121173207258275
adverse27777600012149107157207241283335
effects,3141760001215182116167214251293314
rational3485760001213383117141197254304328
prescribing.340774001215790140179224257280337361416472493
DECLARATIONS:4070252008648871301662142563043393604124625014571252008514
Declaration406926600874987120141179206244271291333375
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