824
KLINICKÁ341804301074588109168189242288347
FARMAKOLOGIE708804301074392139212266313373416475534555599
A13288043010753
FARMACIE1402804301074292139211266317337381
/18048043010757
Klin1880804301077091109157
Farmakol2057804301074278105179220258305325
Farm2402804301074178104179
2022;36(3):85-922601804301074386128172187231275298341362376420463491535576
/31978043010777
www.klinickafarmakologie.cz4568804301076513320121425327329234035839843647950254457164568672477179183988990895196610061045
921858026012657113
be34362101095299
useful46162101095691137164215237
to71762101093685
use82162101095691138
one977621010956107153
model1149621010982133185231253
for142062101093383113
intermittent155262101092778107152182258279310342387438467
and34376101094596148
another510761010950102152183234280311
for84076101093383114
continuous97376101094797148178199251301352403439
administration,1431761010951103180201252273309341371415445467517569588
with34390101096687116165
respective52790101092772107157203243274295338381
therapeutic92690101092978123152195245291340369389429
ranges137390101092871120170215250
saved164190101093578119163214
into18739010109206998146
eachmodel,343104101094486125172259307357400421438
preferablyWIN3798104101094674118143186214256306326367455475533576
/13911041010927
DOS214351041010955115157200
andWIN1/1653104101093886135223243301341366
DOS1,3431181010960122165206220
respectively581118101092873108158204244275296338382403445
(16).1045118101092465107130146
We4831321010976119
did620132101095272123
not7611321010951100129
identify908132101092373118167196216242287
any1213132101094594135
papers1366132101095296146192221256
in1641132101092271
the1730132101093281126
literature187413210109224272115343146101092973101150179223
(PubMed)584146101092370118168241286337362
testing964146101092771106136156205255
the1237146101092776121
predictive1376146101094877122173193233264284327371
performance17651461010948941231512002293431601010975118167207251
of612160101095378
the708160101093483128
Mw\Pharm8541601010976141171219267310338413
models.12851601010979128179224245279298
Fuchs1601160101094794134183218
et1837160101094878
al.193316010109476886
(6)34317410109266992
compared453174101093885160211254283327378
12849174101094382
programs950174101094877125176205248322357
for1325174101092372101
TDM14441741010942102174
in1636174101091867
2013.1721174101094388130169187
All192617410109527393
programs343188101095283133185214259335371
were7331881010973119149194
scored946188101094384133163209261
against12261881010951102146167218253284
pharmacokinetic15291881010958110154183260304345395438461343202101095095125145185
relevance,546202101093580101146188232281321365383
user-friendliness,947202101095590135164189215245266311360411432452501546581616635
computing1600202101094694169220269299319369419
aspects,343216101094478129175215247283302
interfacing,663216101092776105149178207250290311360410429
and1110216101094999149
storage.1278216101094171119148192242287305
Mw\Pharm16012161010978144174222271314343418
and343230101094393143
TCIWorks504230101094797117193240269311348
scored870230101093879126155200251
the1139230101093281126
highest.1283230101095373123172217252282300
Altogether,1602230101095778107155205250280329374403417
five34324410109275196141
programs504244101095889139192222267343379
were9032441010974120150196
able11182441010951103126172
to1309244101093787
handle14152441010957102153205227274
data17082441010958102132178
for1905244101093384114
continuous343258101094292145176198251302354407444
administration,8072581010962116194216269291328360391437468491543595616
irregular1443258101093970102149203255277323354
regimens,18172581010948951491713432721010976122173208227
and5882721010950100152
changes758272101094797140191242287323
in1100272101092777
the1196272101093686131
drug1346272101095787137188
kinetics1553272101094870121166197217258295
due18662721010958107153
to343286101093078
changes439286101093887130179229274309
in766286101091968
renal853286101092771121163184
function1055286101092474123163194215264313
or1386286101094877
interruption148128610109196897141170199248299328348397447
of1946286101094773
drug343300101095281132183
treatment545300101093666111155184261307357387
(Mw\Pharm,9513001010932103170201250300343373449468
TCIWorks,14383001010951102123201249279321360379
MMUSC*PACK©,183630010109791533433141010958100152187234283332379437451
Kinetidex®,812314101094466115159189208258303345383395
and1225314101093988138
T.D.M.S.1381314101094154114130203222268286
2000TM).1685314101094287133180224295318334
Avent483328101095495139189219
et721328101094272
al.81232810109406281
(17)912328101092364104129
compared1061328101093785160211255284329380
seven1460328101093378121165215
Bayesian1694328101094690131175211232275325
dosing3433421010951102138160211263
programs626342101095889140192222267344380
for1026342101093384115
antimicrobial11613421010950101132154230252294324374427450494516
therapy,1697342101093788135166211263306322
including213862101092172114136186239261312364
Mw\Pharm,2522621010974141173223273317348424444
that298662101093283128158
were3164621010969114145191
available337562101094689134156178223275298345
in374062101092374
2019.213876101094693136178196
All23547610109547698
of247276101094876
those256876101092879130167213
programs280176101095081132184214259335372
allow31937610109426486137204
an341776101094293
a-priori353076101094273126157180230261284
regimen,213890101092976128150226273324344
the250290101093283130
first26529010109295384121153
dose2825901010953104141187
handled,303290101095397148201223269322342
and339490101094697149
a3563901010946
non-3629901010952103155185
-steady-state213810410109286596142187239283312349381426457503
situation.266110410109426495146191221243294345366
The30471041010952104150
programs3217104101095990140192223268344381
were36181041010973119150196
not21381181010950101132
assessed2290118101094380116163200236283336
for2646118101092777108
continuous2774118101094190142172194245296347398434
administration.3228118101094496172194245267304335366411441463514565586
All2138132101095679102
programs2261132101095991143196228274352389
allow267113210109517497149218
the2910132101093790137
flexibility3068132101093460108153176230253276299331378
to3467132101093789
choose357613210109491011532062138146101093684
appropriate22431461010952105160191243297329352398429476
target2740146101093884116168216249
parameters30091461010960107138184262310342389421460
to3490146101093789
tailor3599146101093885108131183215
the2138160101093184132
recommendations2292160101093886130182261341389443497544576599652705743
to3056160101093991
a31691601010952
given3243160101096083130177231
patient.34951601010961108140163212265297319
However,21381741010958109175220263308338354
they2511174101092778123166
require2697174101092772124174195225271
skilled298717410109337699120142188240
personnel3246174101094996126163213264314360382
with3648174101096385116166
an2138188101094394
understanding22521881010954105158204235272304349400453475526577
of2849188101095481
pharmacokinetics29501881010956108152182259304345395439462513560591613655693
and3663188101094798150
pharmacodynamics21382021010951103147178254299340390443487538583659681723760
to2918202101092878
use3016202101094784130
and3166202101094293145
interpret3331202101091970100146177229260306338
the3689202101092778125
information.213821610109217299150181258302333355405457477
Conclusion21382415014368130195249274337380404468533
The2278258101094494139
Windows2435258101097293142192241305340
models27942581010970119170215236270
“#vancomycin_adult_k_C2”,30802581010930721131582052422873593974334535005465946406877072138272101092875118166216261293311
“#vancomycin_adult_C2”,2465272101093073115161209247293366405443463511558607655702723751797847893924943
“vancomycin_adult_C2”,34242721010930721171662042503233622138286101093962112162213264314336367415468516550570
“vancomycin_C1”2726286101094691139190230279355397436459510559612655685
and34332861010961114169
DOS36232861010978145191
models21383001010977130185233257294
“vancomycin2468300101093276124175215263340381420442493
(cont.inf.)2979300101093976124175205225248299326345372
%ahz”33693001010984134185224259
and36493001010959111165
“vancomycin2138314101093275123173213261337377417438488
adult”26443141010955104154176205241
in2907314101092981
the3009314101093890138
Mw\Pharm31673141010982151184234286331362441
software362831410109459712516021383281010965107136180
versions2336328101093982111146166214263297
++1.3.5.55826513281010949102139153200218265282329371416
(Windows)3085328101092197118167217265329364386
and3489328101093987137
336443281010942
:37043281010910
303732328101093782
(DOS)2138342101092584147190215
were23723421010962107136181
compared.2572342101093785160211255284329380399
Both2990342101094595125174
DOS31833421010956119162
models33643421010972121173218240274
produced36573421010948781273934621010952102144189242
comparable419662101094897174227272302347400423469
results.468562101093682119170192222260280
The4985621010952104151
best5155621010959106143175
results534962101093783120170192223261
among3934761010945123175228281
the423576101093890137
WIN4393761010985109171
models4584761010984136191238261298
were4902761010976123154201
achieved512376101095295147169217262308362
by5506761010959103
using393490101095085106156207
the416090101092777122
“vancomycin_adult_C2”429990101093173118166205250324362400420468515564611659680708754804849881
(WIN3)5198901010923101123182228251
and546890101094191142
“#vancomycin_adult_k_C2”39341041010930721141592062442893613994364565045505986456927127407858288759249691000
(WIN1)4953104101092299121180221241
models.52121041010971121172217238273292
As5522104101095288
the3934118101092978123
predictions4076118101094777121172192232264284333383417
made45121181010971113164209
by4739118101094789
the4846118101092676120
DOS49851181010956118161
models51651181010971120171215237271
produced54551181010947761253934132101095098137180231
lower4183132101091765129173201
bias,4402132101094768110144162
we45821321010962105
recommend4705132101092569109156230303347396446
the5169132101092674118
addition5305132101093989139159188208256305
of3934146101094976
the4029146101093181126
DOS41741461010961124168
vancomycin4361146101094488139179228304345385406456
models48361461010976126178224246281
into5136146101092272102151
the5306146101093080126
WIN5451146101097799159
software3934160101093686112145214258287333
version.4286160101094387117154175225275295
Limitations3934185501435479177201238293329354418482526
The4093202101094090134
models42452021010971119170214235269
are4532202101093968112
used4662202101094580124174
to4855202101092573
assess4946202101093974108152187222
extrapolations51862021010941821141421852352843053473763963934216101094998133
and4085216101094089139
the4242216101092775120
conclusions4381216101093684133173194242277297346396430
are4830216101093968112
also496021610109406195144
limited5123216101091738112132162205256
to5398216101092674
the5490216101092675120
accuracy3934230101094485125176206251292338
of4291230101095784
these4394230101093788134171217
particular46312301010958103133166188229280302346376
extrapolations,5026230101095296129159204256308330375405426477528564584
not39342441010950100130
to4083244101092978
the4180244101093080126
accuracy4325244101094383123173202246287332
of4676244101094976
the4771244101092979125
models49152441010975125177222244280
in5214244101092070
general.5303244101095096147192222266288307
For3934258101094596127
optimal40812581010958111143165243288311
pharmacokinetic44122581010959112157188266311354404449473525572604626668
modelling51002581010984136190237260283305357409
in5530258101092880
the3934272101093081127
Mw\Pharm,40812721010979146178227277321351428447
all454827210109507294
users4661272101095793139169207
need48872721010957103150203
to5109272101093787
assess5215272101095086122169205242
the5476272101093787134
extrapolations3934286101094588121150194246296318362392413463513548
for4501286101092777107
their4627286101092979125147176
patients.4822286101095296125147192243272309328
Acknowledgement39343110014776129191261330419451513584654717819882952994
Supported4074328101094595147199251281315360412
by45063281010958101
the4626328101093787134
grant4779328101095888132183213
of5012328101095683
University51143281010966116138182227258295316347393
of5526328101095784
Ostrava3934342101096298129159203245289
SGS08/LF2019–2020.42423421010944103147194241272315359404450493534582624670714760778
REFERENCES3443660012357112167220281336407470524579
1.34338200853648
He40638210834782
N,50338210834760
Su57938210833572
S,66638210833548
Yan72938210833868106
Y850382108338
et90338210833759
al.9773821083345063
The105538210833574109
benefit118038210834176115150167184206
of140238210834059
individualized14763821083175594109142158197234266282297326360399
vancomycin18913821083346710534339210833168126157189204242
dosing60039210833978104119157196
via8113921083334981
pharmacokinetic90739210834079111132191223255292323339377412435450482
tools:14043921083236099115141153
a1573392108333
systematic16213921083286087110144202234256271303
review1940392108322563434021083314781132
and49040210832966105
meta-analysis.61040210835489111143165197235266282313340354380393
Ann101840210833876113
Pharmacother.114640210833370102122180212244280302340374395405
2020;54:331-343.15664021083326598131144179213225260292323341373408440453
2.34341200853652
Rybak40941210834174114147177
MJ.6014121083608698
The71541210833877112
pharmacokinetic84241210834483115136195227260297327344382417439455487
and134441210833775114
pharmacodynamic147441210834382114136194227259296336368407439497512544
properties3434221083396097137173194218234268295
of65442210833756
vancomycin.72642210833164102134171229260292307345358
Clin10994221083405570108
Inf12224221083155372
Dis.13094221083466187101
2006;42:S35-S39.142542210833468105140153187220232266300333355386420453464
3.34343200853651
Rybak40843210833971111144174
MJ,5984321083578395
Le70843210833469
J,79243210832739
Lodise84643210833572112127153188
T1049432108336
et110043210833759
al.11744321083355063
Executive125343210833568102134172195210242277
summary:154543210832966124182214235269283
therapeutic1843432108325639811915234344210833974112134150182
monitoring54044210835796134149172209230246284323
of87844210833757
vancomycin95044210833264102135172230260292307345
for13104421083195678
serious1403442108326618398136174200
methicillin-resistant161944210835792114153168200215230245260298320342376343452108326416790123161183
Staphylococcus5414521083325486126164195211249281318351382420446
aureus10024521083327091125163189
infections:12064521083155372106139163178216255281294
A1515452108341
revised15714521083215588103129164204
consensus1790452108332691071331682063434621083266390
guideline4484621083438096134169185200238273
and73646210833775114
review8654621083266092108142194
of107446210834261
the11514621083266499
American1266462108345103138160175207240278
Society155946210833876109124159181215
of178946210834261
Health-system1866462108349841151313434721083226184111144172196230289
Pharmacists,64847210834079112133193226258274301324352366
the103047210832766101
Infectious11474721083205978113147171187226265291
Diseases14544721083516794130162189225252
Society172247210833877110126161184218
of195647210834363
America,34348210834199134155171203236249
the60748210832665100
Pediatric72248210834073113128160182203219251
Infectious9884821083205877111144168183221259286
Diseases12894821083506692127158185220247
Society,155148210833876108124158181214224
and179048210833775114
the191948210832765100
Society34349210833271103119153176209
of56849210833756
Infectious6394921083155371106139163178216254280
Diseases9354921083456086121153180215242
Pharmacists.119249210833572104125184216248264290313341354
Pharmacotherapy15614921083357310512618521724928630834638140243534350210833970
2020;40:363-367.42850210833469101135148183219232267302336357390424457463
4.34351200853651
Abdul-Aziz40951210834281121158174196237268284313
MH,737512108355100113
Alffenaar865512108341577695130168200232254
JVC,113451210832461101114
Bassetti12645121083356895121156179203218
M1498512108355
et156851210833456
al.16405121083324760
Antimicrobial1716512108341791011161741892212422793435221083395587102
therapeutic46152210832765100122155195230268291307339
drug81552210834465104143
monitoring973522108363102140156178216237253291331
in131952210832058
critically1393522108336587396111144177192208240
ill16485221083203550
adult171452210833776114130152
patiens:188252210834477991143435321083347298111
a469532108330
position51453210833776103117140155193232
paper.76153210833770109144166176
Intensive9525321083135173106144171186218252
Care12205321083387092126
Med.136153210835388127140
2020;46:1127-1153.15175321083326699133146180217229259286316349368399426456489502
5.34354200853650
Flannery4085421083355082120158193214248
AH,67254210834388101
Bissell7885421083385380106141157172
BD97554210833884
et107554210833658
al.11495421083345063
Continuous122754210834279118139155193230268306333
versus15755421083346990117154181
intermittent177154210831755771101321902052283435521083225593115
infusion4735521083155372111137152190228
of71755210833757
vancomycin78955210833265103135172230261292307345
and115055210833270109
the12745521083226095
risk1385552108321366292
of149355210833757
acute156555210833264102124158
kidney17395521083304685123158189
injury1944552108315533435621083155274108
in46656210831351
critically532562108330516790105137170185200232
ill7795621083132944
adults:83856210833070107122145173185
a1038562108331
systematic10845621083255784108141199232253269301
review14005621083195385101136187
and160256210833169108
meta-analysis.172556210835691113146169201239271343572108315477488115128
Crit486572108340617799
Care6015721083407394128
Med.74457210835590129142
2020;48:912-918.90257210833468101135148182218231266298328348383415446460
6.34358200853651
Fuchs4095821083306698136162
A,58758210833852
Csajka6545821083386598113143177
C,84658210833750
Thoma91158210833070108166198
Y1124582108333
et117258210833254
al.12415821083294557
Benchmarking131458210833267105137175233265286316333370409
therapeutic1738582108320589211414618522125821383821083213668
drug22213821083355694132
monitoring236838210835592130145167204225240277316
software:26993821083236180105157189210244256
a2970382108329
review3014382108318528399133184
of321338210833453
available32813821083296093107122154193208243
computer353938210832864122161198221254275
tools,21383921083225997113139152
Clin23063921083395570108
Pharmacokinet.242939210833572105126184217249286316333371406428441
2013;52:9-22.288639210833468100130141176209222257280311346359
7.213840200853645
Mw\Pharm2198402108353104129166203236257315
3:3025284021083334480114
a2657402108331
MediWare270340210835388128143201233254288
Product30064021083345592131169201225
in324740210831351
cooperation331340210833067105145180202235256272310348
with:36764021083506588126138
University21384121083448297129163185212227249283
Center243641210834276114135169190
for26424121083205779
Pharmacy,273641210833775107128187219251285294
Dept304641210834782121143
of320541210833958
Pharmackokinetics327841210833775107128187219251281319349366404439461476508536
and213842210833372112
Drug226642210835274114154
Delivery,243642210835289105121154190212247257
University270942210835190105139174196225240264298
of302342210834464
Groningen,310342210835073111151167206246282321335
The345442210833879115
Netherlands.35854221083518811115018620821384321083154888128155169
Supervision232343210833977117154176212228255271310349
DKF268843210835289124
Meier,282843210836197113148170181
JH302543210833076
Proost.311743210834163101141168192206
Copyright333943210834685125158180197237276298
19871999365343210834071107141213844210833464100135
MediWare.228844210835590129144203234255289302
8.213845200853652
Brozmanova220645210834163101129188221259298331364
H,258645210834962
Kacirova266445210834074107122144181214247
I,292745210832033
Urinovska29754521083507187125164196223254288
R3278452108341
et333545210833962
al.34124521083385366
New349445210835086137
liquid36474521083203574113128167
chromatography-tandem21384621083316991128186219240277317338371411449480502524557595635670728
mass288146210836295121148
spectrometry304446210833271106139163185222280316338359394
methods345346210836298120158197236263
for37314621083236183
routine21384721083215897120135174209
TDM236347210833885141
of251947210834362
vancomycin259747210833770109141179237268300316354
in296747210831958
patients304047210834478100115150189211239
with32944721083567295134
both344347210834484106144
normal360347210834382103162195211
and213848210833269108
impaired226148210831270108141156177211250
renal25264821083185290122137
functions26784821083165492124148163200238264
and295848210832966105
comparison307848210832966123162195216231257295333
with34264821083486386124
results35654821083185278115130152180
of376048210833454
polarization21384921083387692123144159188221242257294332
fluoroimmunoassay24854921083143067105126162177234291328365403435461487520550
in305049210831249
light31144921083122765102123
of325249210833453
varying33204921083296181115130167206
creatinine35414921083284982113135149187201238273
concentrations.213850210833168107139172211232253286308324362400426440
Clin25935021083405570108
Chim27165021083407893151
Acta28825021083417397130
2017;469:136-143.302750210833468100129139174210244257287317351375405437469482
9.213851200853649
Jelliffe2203512108322577388103122141176
RW,239451210833391101
Jelliffe2510512108322577288102122141175
SM.27015121083308498
A2815512108338
computer286851210832966124164202224258279
program31625121083375895135156189247
for34245121083165475
estimation3515512108331588196154186208223261300
of213852210833756
creatinine22085221083294983114135150187202239273
clearance24965221083284377108129161199230263
from27745221083163774131
unstable29205221083347197120152190205240
serum31745221083245879116173
creatinine33625221083284982113135149187201238273
levels,36505221083124677111126151164
age,213853210833271106118
sex,22715321083266193106
and239353210833169109
weight.251753210835085100139177198212
Math.274453210835487109147160
Biosc.1972;14:17-24.29195321083365189116148161192222255289302332363375405434453484516528
10.21385420085367085
Du223854210834886
Bois23405421083377691117
D,247354210834758
Du254754210834786
Bois26485421083387692118
EF.27815421083356774
A2870542108344
formula29295421083215880138176191223
to316854210832461
estimate32445421083366386102159192213247
the35075421083246297
approximate361954210833473113135172213855210833046103136157191
surface23445521083256384105139171205
area25645521083315286118
if269755210831433
height27455521083377287126164185
and294555210833169108
weight30695521083498399137175197
be328155210833873
known.337055210832868106157196209
Arch35945521083406192130
Intern37405521083135121385621083225577115
Med.226956210835489129142
1916;17:863-871.24265621083346497128140170199210244280313335371404437446
11.21385720085366779
Chennavasin223357210834684120158197229261295321336375
P,262357210834146
Brater26845721083416396118152174
DC.287457210835092106
Aminoglycoside2995572108347105121159198238253286317355382397436471
dosage348257210834482109143182218
adjustment37155721083387721385821083155380104163198237259
in241358210832058
renal24875821083266199132148
failure:2651582108324577389127148183196
a2862582108338
hand-held291658210834376114154177216252268307
calculator32395821083377086119157173206228265287
program.354258210834466104144166200258272
Eur39343821083336990
J4040382108324
Clin40793821083405570108
Pharmacol.420238210833573105126185217249286302315
1982;22:91-94.453238210833565100133146181215228263295314349385397
12.39343920085366884
MW\Pharm4033392108355112140177214246268326
Manual437439210835587125163195211
version46003921083326687114129167206
3.15,48213921083344777107119
1995.495539210833464100134146
13.39344020085366883
https://tdm-monografie.org/monografie/vancomycine403340210834365891291561681952162382763353574164554935325715936266446616967087467688068328899279661004104410651099111611331168119512271260129813311368142614571489150415421577
[in39344121083193573
Dutch],402241210834584106137175192205
assessed42424121083325985120147174209248
Jan45064121083245694
3rd,46154121083345593106
2022.473641210833468101136149
14.39344220085356781
Rodvold402942210833269107138174189226
KA,42694221083327487
Pryka43714221083315083112145
RD,45304221083317686
GarrisonM,46304221083407191112126151188225289302
et494642210833051
al.50114221083294355
Evaluation50804221083295991105141172192206243280
of537442210833452
a5440422108328
two-548242210831870106128
-compartment39344321083215490148186219239263321355393414
Bayesian436243210834072103136163177208245
forecasting46224321083236081114146179205227242279317
program495443210834364101140160193250
for52184321083236081
predicting53144321083436497136151182206220258296
vancomycin393444210833163100131167224254284298335
concentrations428344210832864101132165202222243275295310346384409
Ther470644210832968101122
DrugMonit.484244210834263100138203240277291313325
1989;11:269-275.51824421083305993126138167194202236268301323353385417428
15.39344520085377187
Shingde40384521083428198137178219256
RV,43104521083458493
Graham442045210835376111151185245
GG,468245210835399114
Reuter481345210834481121145180203
SE503245210834276
et512545210834367
al.52084521083415872
Comparison529645210835089149191225248264292393446210833776
of402646210834262
the410346210832766101
area42204621083375892125
under436046210834381120156177
the455346210832665100
curve46694621083367496131165
for48504621083236183
vancomycin494946210833770108141178237268300315353
estimated53184621083396689105163196218252291
using39344721083376378116155
compartmental410547210833572130169202223248306341379401433449
and456947210833674113
noncompartmental469747210834280118151187246285318339364422457495516549565
methods527747210836196119157195235261
in555347210831957
adult393448210833271108124146
patients40954821083437698113148186208235
with43464821083547092130
normal449248210834180101160192207
renal47154821083245897129144
fiction.4875482108321377094109147185199
Ther.508948210833776111132142
Drug.524748210834971109148161
Monit.542448210835896135150172186
2019;41:726-731.393449210833468100130143178208217250284318341373407438447
16.39345020085366984
Schön40335021083306299137175
K,422350210833246
Koristkova42845021083337091106132155184221253285
B,458450210833345
Kacirova46445021083326697112133170201234
I4893502108312
et492050210833153
al.49885021083294457
Comparison506050210833773131170202223238264302340
of541550210833453
Mw\5483502108351102127
Pharm393451210833573105126184
3.3041345121083364884118
and426851210833371110
Mw\Pharm4393512108357108133169207239260318
++472751210834386
a4829512108333
Windows487751210836076114153191242269
version51615121083346889116131169208
of538451210833958
pharmacokinetic545851210834078111132393452210835790122159189206244279301316348
software42985221083246282107160193214248
for45615221083175576
PK/PD46535221083336897133178
monitoring484652210835694133148170207229245282321
of518352210833655
vancomycin.525352210833063101133170229259291306344357
Part39345321083356788113
14062532108334
–4112532108335
a4162532108332
posteriori420953210833978104128161183198236258273
modelling.449853210835795135170185201215253292305
Comput481953210834077135174212235
Methods506953210835590112150189228254
Programs53395321083355693132154187244271
Biomed39345421083355188146181221
2021.41705421083326699130139
Comput432554210833774132171209232
Methods457254210835287109147185225251
Programs48385421083335491130151184242268
Biomed51215421083334886144179219
2022;214,53555421083326699133145180212243255
https://doi.org/10.1016/j.cmpb.2021.106552.39345521083385983123150162189209245283299312350371409436469500513543575607638663679692724782821861873909943976100810171048107911151149118112141227
17.39345620085376978
Avent402956210834778113152175
ML,421956210836194108
Rogers434356210834281121157179207
BA.45665621083418399
Optimising468056210835494117133192208235250289329
antimicrobial50255621083387799115174189222244282323339372388
therapy542956210832766102124158393457210833970
through40195721083256485122160199237
the42715721083256499
use438557210834067102
of450257210834160
Bayesian457757210833972103137164179211249
dosing484157210834280107122159198
programs.505557210834263101140161194252279292
Int53625721083195778
J5456572108327
Clin54985721083445974112
Pharm393458210833573105126184
2019;41:1121-1130.413458210833468100130143178208216246274304335354385412442477489
ORIGINÁLNÍ341201012673138172244278352422476549582
PRÁCE944201012661125197257315
COMPARISON34132701063272127163200237255289330373
OF72932701064072
MW\PHARM817327010654113143177219260296352
3.3011843270106344983117
(DOS)131632701062463105138163
AND149532701063981122
MW\PHARM1632327010654114143178219260297352
++2000327010655110
(WINDOWS)212532701062484103145185227287321345
VERSIONS248632701063870107142160202244278
OF277932701064072
PHARMACOKINETIC286732701063576117153209250285324361380422455489508543
SOFTWARE342632701063274106141203241277310
FOR375232701063072109
PK/PD387732701063471100135175
MODELLING406832701065495136169201234252294335
OF441832701064072
VANCOMYCIN450632701063875117153193248285318337379
IN34143501061557
CONTINUOUS41443501063474116150168210252293336369
ADMINISTRATION79843501064080135153195213247280317360389407449492