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Klin2730804301077091109157
Farmakol2907804301074279105179220258305325
Farm3252804301074178105179
2022;36(3):85-923451804301074487128172187231275298341362376420463491535577
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KLINICKÁ41438043010772115136195216269315373
FARMAKOLOGIE4537804301074292139211266313373415475534555599
A51568043010754
FARMACIE5230804301074392140212267318338382
9156558026012657112
Linear34362101094262110155197225
regressions58662101092569119147191226260280328377411
were1015621010961105134177
near121062101094690132160
ideal,138962101091766110152173191
with159862101096182111159
the177562101092674118
exception19116210109418234376101094082132161181229278
of63976101094570
the72776101092573118
one-compartment86376101094493137166208255328378420449480553597646674
WIN4model.155576101097192150195282331381425446464
Discussion3431010014782114164219287338387418487556
Continuous3431295014368130195231255319382446510554
administration9251295014355121219243307332375413449504540565629693
The483146101094595140
advantage641146101094797140183232261304354399
of1058146101095378
continuous1155146101094391140169189238287336385420
administration159314610109479717119224126129632635439734316010109305099149
of510160101095581
vancomycin609160101094993142182230305346385405454
is1082160101092661
a11611601010949
lower1228160101092776142186215
risk146116010109355690132
of1611160101095581
nephrotoxicity,17101601010956101152202230279343174101093078118139179199229273287
despite6481741010956101136187208237281
aiming947174101094969144164213263
for1229174101093180110
a13571741010949
higher1424174101095576125175220249
therapeutic169117410109358513015920225229834318810109507999139
range.500188101092871120170215232
As751188101095389
described858188101095094129169198219269315366
by1242188101094991
Flannery1351188101094262104153202247276321
et1690188101094473
al.’s17821881010941628096128
(5)192818810109246791
meta-analysis3432021010975120150193221264313356376419454474508
of869202101094873
critically96020210109396788117137177220241261303
ill128120210109194060
patients,1359202101094993121141186236264300319
the1696202101092777121
odds1836202101094798148183
of343216101094975
acute436216101094989138167211
kidney665216101094769120169214255
injury93821610109277697145174219
declined11752161010956101141162182231276327
by1520216101095798
50%1636216101095297168
compared1822216101094694169343230101095193121165215
to575230101092673
intermittent66623010109166593136164238257286317360408436
administration.1120230101093988161181230249283312340383411430478527545
However,16832301010954102166209251294322336
continuous343244101094190141171191242292342393428
administration7902441010950102178199250271306337367411441461512563
of1371244101095783
vancomycin1473244101095094145186235311353393414464
is1956244101092863
rarely343258101092973101146167209
used570258101094883128179
in767258101091969
our854258101094897126
area,998258101094270115157176
and1192258101094291142
if1352258101091945
so,1415258101093584101
only1534258101094898118160
in1712258101092069
intensive17992581010920699814219134327210109365699143
care505272101094689118162
units6862721010955105125154191
(ICU),895272101093151104161185202
as1115272101094984
it1217272101092756
is1292272101092661
preferable1371272101095787131157202232275326347392
to1782272101093583
use1884272101095590135
a3432861010943
central405286101094589139167196239260
line68328610109274796141
due8422861010956105150
to1010286101093583
possible11122861010956106141176196246268312
endothelial14432861010950100150199228277322343364406427
cell1888286101094689110131
toxicity343300101093078118139179199228272
(5).63430010109317498114
The7663001010950100145
disadvantages929300101095677111155205248291340369413462507542
are:1490300101094877121139
one16473001010955104149
intravenous1814300101092776105133177343314101094488139189239275
access636314101095090130175210246
is900314101092763
permanently9813141010958104134210254304350400429450493
occupied,1493314101095697137186238259305357375
the1887314101093686132
patient’s343328101095193122141185234262283314
movement6753281010970119160203277321370398
is1090328101091751
restricted,1159328101092569103132161181220250294344361
and,1538328101093987137155
from171132810109225198172
the1901328101092574118
clinical34334210109405978126145183225244
point605342101094594113161188
of810342101094469
view,896342101093858101165179
in1092342101091664
the1173342101092572116
case1306342101093577110153
of1477342101094468
underdosing1562342101094592141184212261308342361408457
the343356101093080126
plasma488356101095779123158233277
levels784356101092773116160182217
remain1020356101093581157200221271
insufficient1310356101092777112162188218241282302348399428
for1756356101093383113
the1887356101093686132
entire343370101094595123143172216
duration578370101094998127170199219268317
of914370101094874
the1006370101092978123
dosing1147370101095099134154203253
interval.141837010109206998142171216259280298
Model3433955014393158225283309
selection6793955014346105130189244284309373437
TheMw\PharmDOS483412101094493136220284313359406448475548620681722
version1223412101093880108143162210258
offers149841210109456997140168203
twomodels1718412101092591138225272343426101095093113146
for50642610109226997
continuous620426101093682130157177224271319366400
vancomycin1037426101093880127166212285324362381428
administration,1483426101093887159178226245278307335376404423471519536
while2138621010966116136157201
the235862101092978123
Windows249962101097697147197246311346
version286362101094387116152172221270
offers315262101094975103148177213
several338362101093580123166195239259
models3660621010975124213876101095195117151
for230776101092372101
the242676101092675120
prediction256476101094877121172192232263283332382
of296476101094672
vancomycin305476101093982132172219294335374394443
kinetics.351576101093961110155184204244280299
With2138901010978101131182
paediatric2340901010958103150203224269299329351392
models2751901010983135188234256292
excluded,306390101095296136157208261307360379
four346290101093383135165
WIN3646901010984107168
models21381041010974121171214234267
remained2423104101092467140181200248292341
available2781104101093979120140159200249270313
for311110410109226997
the3226104101092472115
prediction3359104101094674117166185224254273321369
of3745104101094469
continuous2138118101094086135162182229277325373406
vancomycin2562118101093880128167213286326364383431
administration3010118101093988160180228247281310337379407427474523
in3550118101091664
adults.3632118101093887135154213813210109306786
According22431321010962102141190220271292343394
to2655132101093685
the2759132101093686132
MW\Pharm29101321010979156190239288332361438
manual33661321010982126176226270291
(12)3676132101093174114137
and2138146101094494145
manufacturer23011461010982125175224251295335367416446491520
personal28401461010957103133169219269312333
information3192146101092776102152182257301330351400450
(13),3661146101093173113136153
the2138160101093080126
source2282160101094292142172212256
of2557160101095582
population-based26571601010958108160211232275304325375425454507551586632684
data33601601010957100129174
for3552160101093382112
the3683160101093685131
DOS221381741010960122165209
andWINmodels2365174101093988138228250308397446497542563597
was29801741010962105139
a31381741010939
study3195174101093262110161203
performed3416174101094792121149198227302347397
by2138188101095192
Rodvold2249188101094695146189237258308
et2575188101094373
al.266618810109416180
(14).2764188101092364105128144
Patients2926188101094688117137181231259295
in3240188101091868
the3326188101092776121
reference346518810109277298142172216265305349
group,2138202101095179128178229246
compared2402202101094694169220264293337388
to2809202101093583
our29112021010955104133
patient30632021010957100129149194244273
group,3354202101095685134183234252
were36242021010972116145190
younger2138216101094291140189239284313
(552469216101092266108
±25962161010950
162664216101094284
yrs2766216101093868104
vs.288821610109407593
662999216101094390
±31072161010950
123175216101094382
yrs),3275216101093968104126142
their3436216101092675120140169
body3623216101094898149191
weight21382301010966110131181230259
was24152301010966109144
slightly257723010109365677126176204225267
higher2862230101095070120169214243
(883124230101092569116
±32582301010954
21kg3330230101094688140188
vs.353623010109447998
853652230101094691
±37612301010953
16kg),2138244101094790143194218235
and23922441010951101153
had25642441010957101153
lower2736244101092879146191221
renal2976244101093682133177198
function3194244101093283134176208229280331
(serum3544244101093266112143193270
creatinine2138258101094069113156185205254274323368
1.42524258101095063109
±26512581010957
0.8mg/dL,2726258101094967114199249280326368387
i.3131258101092442
e.3191258101093754
123.8μmol/L3263258101095089134152199258333382403434476
±37572581010957
70.7μmol/L2138272101094690107152211286335356387429
vs.258627210109427795
1122700272101094582121
±28392721010953
70µmol/L).2910272101094589148223272293323366390406
Because2278286101094994135179227262307
of2604286101095581
the2703286101093585130
high2851286101095676126176
correlation3045286101094694124153198219262291311360410
between34742861010956102132200244290340
fluorescence213830010109264998147175220254294338387427470
polarization2626300101094797118160189209247291320340388438
immunoassay3082300101091791165213263311354389423467507
(FPIA)3607300101092264109129183207
and2138314101094495147
LC-MS/MS23033141010950100123198243273346391
analytical27133141010950100144166209242263304348369
techniques,3101314101093782123174224245297347393429448
where35683141010973124170200246
linear213832810109214191135178207
regression2363328101092772122151195230265285334384
models27653281010973122173218239273
are3056328101094271115
near3189328101094893136164
ideal3371328101091970114157178
(8),356732810109236791107
the3692328101092877122
choice2138342101094089138159198242
of2398342101094671
analytical2488342101093988131151194226246285329349
method28553421010972117146195244295
for3168342101092372101
model32873421010971120171216237
estimation35423421010941761061272012442138356101093051101151
(i.230835610109325271
e.2397356101093756
FPIA)2471356101095097117172197
is2687356101092762
not27683561010956106136
expected2923356101095194146192234266310362
to3304356101093685
have34083561010956100142186
been36133561010958104150201
responsible2138370101093075110161212262297317369390435
for2592370101093282111
any2722370101094999140
significant2881370101094162112162183209232273317366395
differences3295370101095778104133178208253303344388423
in3737370101092777
model21383841010975124175220241
outcomes.2397384101094998127166214289334369387
As2278398101095591
models23873981010972121172217238273
are2678398101094069113
usually2809398101094781130172193213255
based3082398101094992127171222
on3323398101094695
a34373981010940
different349539810109486894123167196241290319
reference213841210109297399143172216265305348
population2504412101094796147196216258287306355404
than2926412101092675117166
the3109412101092675119
population3246412101094797147196216259287307356405
that3669412101092574116145
is2138426101092155
being2212426101095297118167217
examined,2447426101094688131206226275320371389
their2854426101093180125146174
potential30474261010952102131174224253273315336
differences340142610109527298127171200245294334378413
must3934621010974122156185
be413762101094791
considered424662101093683132165185234278307350401
to466462101092673
avoid475562101093879126146196
inaccurate496962101091665107146184232260302330373
prediction53606210109477511916918922839347610109305099149
and410176101094291142
insufficient426176101092069104152178207230270290334384412
therapy.469276101092978122152195245286301
Four407490101094491139167
WIN425890101097797155
models4430901010975124174217238271
and471890101094492142
two487790101093097144
DOS5038901010960122164
models5219901010975123174217238271
for550790101092775103
prediction3934104101095382127179200240272292342392
of4345104101095581
vancomycin4445104101094993143184233309350390410460
concentration4923104101094796146187231282311340384413433483534
during54751041010957107393411810109294997145
continuous4096118101093682130158177225272320368401
administrationwere4514118101093888160180228247280308336378405424472520599641669712
compared5243118101093582155204246274317367
with3934132101096585112159
the4110132101092471114
valuesmeasured.424113210109387998145187221306349390423470497539588605
The4862132101094088131
results5009132101092467100146165193227
presented5253132101094573115148191239266308357
showthat3934146101093582129191232278319346
vancomycin4296146101093879126163209281319356375422
concentrations4734146101093580127165207254281308349375394441488520
predicted5271146101094572114163182219248290339
by3934160101095090
allmodelswere404016010109385776161208257300319352428470498540
statistically4596160101093059100127146178206225262304323341381
different499416010109456488115157185227274301
fromthe531216010109214895167208255298
valuesmeasured.3934174101094283102148191224308351391424470496538587603
%PE45541741010964109150
in4720174101091562
two-compartmentmodels47991741010924881341622022473193674084344645365786256527377833934188101095195115148
(DOS1,4100188101092178140182222235
DOS2,43521881010956117159202219
WIN1-WIN3)4588188101097293150191214289309367411432
varied5038188101093981109128172222
from−7.4527718810109225199173239279288333
to−3.2%,3934202101092975140182197243311329
which42792021010960108126164211
couldbe4507202101093480127146195257300
consideredas4824202101093480128160179227269297339388442475
clinically531620210109345371119137175216235254294
insignificant.3934216101092168101119167214233257279317358405432449
The%PE4400216101093987130212258298
values471521610109387998145188221
producedbyDOS14953216101094573119168215253295344406446516576618657
and3934230101094492142
by4094230101095696
other4208230101095482131175204
models44292301010980129179223244277
were47242301010971114143186
in4928230101092674
high5020230101095574123172
correlation5210230101094592120149193213255283302351400
with3934244101096686114163
linear411424410109193887131172200
regression4331244101092871121149192226260279327376
line472424410109193887131
(near4872244101092369113155183
ideal).5072244101091968112154174198213
This5302244101094392111145
means546424410109731173934258101094391124
that4074258101092573114141
the4232258101092572115
large436425810109165885133176
bias4557258101094665106139
producedby4713258101094674121170217256298347410450
unexpected5180258101094492135176225269308338380430
outlier3934272101095099128148168213242
values4193272101094992112161206241
was44522721010971114149
caused4619272101094589137172216268
either4904272101095171100149194223
by5145272101095698
sampling5260272101094185159210231251300350
error3934286101094573102149177
or4129286101094674
unstable4220286101094795129158200250270314
condition4551286101093784133182202230249297346
of4914286101094771
a50032861010940
critically506028610109376585113132171213233252294
ill537128610109183757
patient,54452861010948901181383934300101094594121139
something4090300101093281154199227275295343392
not4499300101094795123
possible4639300101094897131164184233253297
to4953300101092774
be5044300101094892
predicted5154300101094775119169188227257300350
by5522300101094788
anymodel,3934314101094392131220269319363383400
as4351314101094074
seen4442314101093377121170
in4629314101091866
Add47133141010952100150
Fig.4880314101094160109126
150233141010943
and5084314101094088138
Add52393141010952101150
Fig.5406314101094160109126
2.5549314101094361
Even4074328101094588133183
though4276328101093686137187238288
only45833281010956107128171
an47733281010950100
error4892328101095181111161191
of5102328101095682
8%52033281010952125
for5346328101093383113
the5477328101093687133
one-compartment39343421010951103150181225275353406451481515592639691721
model46753421010985137190237259
has49543421010959104141
been51143421010961109156208
described534134210109611081451872172393934356101095197148
in4100356101092575
the4193356101093483128
literature433935610109264675119148191220269298342
(15),4699356101093071111135151
the4868356101093483128
WIN450143561010981102161207
one-compartment523935610109541031481782202673423934370101095398128162239286338368
model43213701010984136189236258
produced4598370101096091142195246287333386
a50043701010951
%PE50753701010980129174
of5268370101095885
−21%,53733701010962105148216237
whichmakes39343841010965113133171219306348388430464
it4415384101091745
unsuitable4478384101094492125172192220262311332375
for487138410109216997
TDMof4985384101094099169230255
vancomycin52573841010939811291672142873263934398101094060110
under4062398101094998148193222
continuous4302398101094087137166186235284333382417
administration.4737398101094293167187237257291321350393422442491540559
As4074412101095591
a41834121010940
different424141210109476793122167196240290318
(higher)457741210109227191141190235264288
therapeutic4883412101092675120149192242288337366386426
range5327412101092669118168213
is5558412101091752
used3934426101095085131182
for4135426101093281111
continuous4265426101094694145174194244293343393428
administration,47124261010949100175196246266301332361404434454504554573
it5303426101092757
might53784261010981102153203232
Fig.340446501124771125149
6.507446501124974
Comparison626447001074891163209254280298328372419
of1061447001074467
%PE11444470010764106144
produced1304447001074571115161206244280326
by1646447001074480
(A)174344700107237094
WIN11853447001077290145181
and2051447001074491136
DOS122034470010756114152188
model,24074470010771116162200219234
(B)265744700107236688
WIN22761447001077290145185
and2962447001074591136
DOS131144470010756115153188
model,33184470010771116162201219234
(C)356944700107236993
WIN33679447001077189144184
and3879447001074491136
DOS140314470010756115152188
model,42354470010771116162200219234
(D)4485447001072379101
WIN44602447001077290145186
and4804447001074591136
DOS1,49574470010755114152187199
(E)517244700107236185
DOS152744470010755114152187
and5477447001074591136
DOS2.3404580010756115153193208
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R35504580010744
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R,4011458001074361
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(A)1969608301122887115
(D)2869758501122888115
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PRÁCE5297208012661125197257315
COMPARISON106833401063272127163200237255289330373
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MW\PHARM1544334010654113143177219260296352
3.3019113340106344983117
(DOS)204333401062463105138163
AND222233401063981122
MW\PHARM2359334010654114143178219260297352
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(WINDOWS)285233401062484103145185227287321345
VERSIONS321333401063870107142160202244278
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PHARMACOKINETIC359433401063576117153209250285324361380422455489508543
SOFTWARE415333401063274106141203241277310
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MODELLING479533401065495136169201233252294335
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IN466344201061557
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