751
KLINICKÁ341804301074588109168189242288347
FARMAKOLOGIE708804301074392139212266313373416475534555599
A13288043010753
FARMACIE1402804301074292139211266317337381
/18048043010757
Klin1880804301077091109157
Farmakol2057804301074278105179220258305325
Farm2402804301074178104179
2022;36(3):85-922601804301074386128172187231275298341362376420463491535576
/31978043010777
www.klinickafarmakologie.cz4568804301076513320121425327329234035839843647950254457164568672477179183988990895196610061045
881828026012657116
The394062101094598144
best4104621010959106143174
outcomes4298621010957108139180230307354390
in470862101092879
terms480762101093782113190227
of505362101095784
%PE,5157621010979128173192
RMSE,5369621010956131176221241
Bland-Altman394076101094970113163214243298319348423466516
bias447576101094869112147
as464176101094075
well4735761010963108129150
as490476101094075
Pearson’s499876101094588131161197247297315347
R5364761010945
were5428761010963107137182
obtained3940901010949101131175197247292344
with430390101096385115165
the448790101092777123
DOS24629901010957120163208
model.4856901010972122174220242261
WIN1513690101097395155197
produced5352901010949791281802293940104101094186139
the4098104101093788134
lowest4252104101092878145191227259
%PE45301041010979128172
and47211041010951102154
Bland-Altman4894104101095678123174226255312333364440485536
bias5449104101095881125161
(Table3940118101092673111162184230
3,4189118101095169
Fig.4277118101094868119138
2)4434118101095175
among45281181010947122173223274
the4821118101093484130
WIN49701181010980102162
models,51511181010979129181227249284304
but54741181010955105136
the3940132101092978123
correlation4082132101093684113143187209251280301349399
(Pearson’s4500132101092268111154183219268317335367
R)4886132101094469
between4973132101094893123190234280329
the5321132101092675120
predicted54591321010948771213940146101095171112144188239
and4198146101094090141
measured43581461010971117160195244274319370
vancomycin4747146101094084133174222297338378399448
values5214146101094084105154200235
was54681461010963107142
less3940160101092167104140
tight4099160101093658109159189
(Fig.430716010109337697148167
3).449416010109537693
RMSE46071601010955128173218
was48441601010973117153
the5016160101093787133
same5169160101094287162209
while53971601010973124145167213
%PE39401741010971119163
and4122174101094595146
Bland-Altman4287174101095072115166217246301323353428472522
bias4828174101095274117153
were50001741010967112142187
almost5207174101094466141191226257
the5483174101093181127
same3940188101093579152197
in4155188101091867
the4240188101092675120
WIN34378188101097293152196
model,45931881010970119170214236254
with4865188101096283113161
a50451881010939
slightly510318810109315272122171200220262
better5384188101094792122153197226
correlation3940202101094089119149194216260289311360411
than4370202101093080123173
the4562202101093080126
WIN14707202101097698158201
model.49272021010975125177222244263
Comparison39402275014368130229295350385411454518583
of4550227501436697
pharmacokinetics46752275014368132186221320374428490541568632690727752806852
parameters39402415014366122156212310368405462497542
The4080258101094699146
DOS242462581010969134180226
and44932581010951103156
WIN1–346692581010985108170215258305
models49942581010984136190237260297
use5311258101095895142
the5473258101093890137
same3940272101093783161208
population-based41692721010959112165218240286317339391443474528574611659713
pharmacokinetics49022721010959112157188267312355405450474526573605627669708
parameters3940286101095196126170245291322367397434
(Table4393286101093279118169191237
2).464928610109537794
The47622861010952103149
DOS149302861010966130174216
model51652861010982132184230252
uses5436286101095692138174
lower3940300101092169134177206
V14164300101094690
and4272300101093988138
both4428300101094796125174
rate462030010109266897140
constants,4779300101093683132166196239288316352371
whereas51683001010962111155184228270305
the5491300101092674119
one-compartment39403141010949100146176219268344395440469502577623674703
WIN446633141010982104164211
model48933141010981131183229251
uses5163314101095692138174
higher5356314101095677128178224254
V13940328101095095
and4054328101094393145
renal4218328101092974125168190
fraction.4427328101092657101142174195245295314
When40803421010975125170220
compared4319342101093684159209253282326377
to4715342101092675
population-based4808342101094898149198219262291311360410439491534569614665
data,5492342101094790394035610109307493
all405235610109406283
two-compartment4154356101092795144175217266341393437466499574620670699
models48723561010972122174219241277
used5167356101094782128180
higher5366356101094768118168214244
V1,3940370101095095109
rate4068370101093175104149
constant4236370101094190140176206251301330
k12,4585370101094346263767064275146783701010919
and4716370101094494145
fr,488037010109275873
with4972370101096789119169
the5160370101093080126
exception530537010109468912817322525527639403841010949100
of4059384101095279
fr4157384101092959
in4235384101092474
WIN2,43283841010979101161206225
while45723841010969120141162208
k2147993841010945484739070642752
was49183841010969113149
slightly508638410109385980131181211232275
lower.5380384101092474140185215230
WIN439403981010978101162210
used4169398101095894141195
higher4383398101095880132184231262
V146643981010958104
and47883981010951102155
lower4963398101092880147193224
fr.520739810109346581
WIN1–353083981010984107168212256302
models39404121010976128181228250287
used4247412101095793140193
slightly446041210109436587139190221243287
higher4767412101095779131183229260
V150474121010958104
than5171412101093688132184
DOS1,53754121010967132177220235
0.22–0.243940426101094766115161205256275324368
vs.4328426101095086106
0.204454426101095372121167
L/kg4640426101093570114164
LBMc,4823426101095099173214234
P50774261010954
<0.0001.51514261010960119138185234282326341
k1255114261010949555843270642752
was39404401010966110146
higher4105440101094869119170215245
in4369440101091969
WIN14458440101097496155198
and4675440101094292143
WIN34837440101097496156201
−1.275058440101095192107155199
and5277440101094191142
1.25,5438440101094459108154172
respectively3940454101093075112163210252284306350395417461
vs.4420454101095086106
0.99,4546454101095371117164181
P47464541010955
<0.0001.48204541010961119138185233282325340
DOS251794541010967131175221
used5419454101095692139191
higher3940468101095071122172218248
V14207468101095398
and4324468101094696147
k12,4491468101094545344747064275145854681010919
whereas46234681010969120165195240284320
its496246810109245491
k2150724681010945512047470642752
was51924681010969113149
similar5360468101093960135156177221250
to3940482101093079
DOS140384821010960123167209
(Table4266482101092573111162184230
2).451548210109467087
Comparison39405075014368130229295350385411454518583
to45505075014339101
DOS146785075014379161216267
model497250750143100164231289315
All4080524101095780103
three4204524101094699130178227
two-compartment44525241010946118169202248299378432479511546625673726758
WIN52315241010993118180
models543252410109931453940538101095196118154
(WIN1-WIN3)41135381010929107129188231256332355414460483
produced4615538101095484134186235276321373
similar5007538101093960135156177221251
%PE52775381010974122166
and5462538101094797148
RMSE39405521010948122166210
when41695521010966117162213
compared4401552101094089164216260290335387
with4807552101096687118168
the4994552101092979125
DOS151385521010960123167209
model53665521010974124176222244
(Table3940566101092571108158179224
4).418256610109426581
%PE42815661010967114156
and4455566101093988138
Bland-Altman4611566101094566108157207235289309338412454503
bias5132566101094768110144
were52955661010961105134178
the5491566101092674119
lowest3940580101092170135179215245
in4204580101091767
the4289580101092776121
WIN24429580101097294152197
model,46445801010972121172217238257
whereas49195801010963113158187232275309
RMSE52475801010945117161204
was54705801010962105140
the3940594101093080127
lowest4086594101092878145190226257
and43635941010950100152
Pearson’s4534594101095599143173210261312330364
R49175941010955
was49915941010973118154
the5164594101093687133
highest5316594101095778130180226263294
in3940608101092171
the4030608101093383129
WIN341786081010979101161206
model.44036081010978128180226248267
%PE,46896081010974122166185
Bland-Altman4893608101095274117167219248303324355430473524
bias,5436608101095475119154174
and3940622101094494146
Pearson’s4105622101095498142172209259310328362
R44866221010955
were45606221010973118148194
higher,4773622101095678129179225255270
but50636221010957108138
RMSE52216221010955128173217
was54576221010973117153
similar3940636101093657132153174218248
in4207636101092474
the4300636101093484130
DOS244496361010963126170215
model,46836361010979129181227249267
compared4969636101094493169220264294339391
to5379636101093483
the5481636101093383129
WIN39406501010978102163
models.41246501010984136189237260297317
The44616501010953106154
one-compartment46356501010958110158189234285363416462493527605653705736
WIN453916501010985109171219
model39406641010975125177223245
differed4204664101095677104134179209255306
most45306641010980131166197
from4746664101093263112188
the4953664101093686131
DOS251036641010966129173218
model.53406641010981131183229251270
Bland-Altman3940678101094869112161211239294314344417460509
plots4467678101094869118147183
for4668678101092372101
all478767810109406081
model48866781010971120171215237
comparisons5141678101093784158209252281302336385434469
are3940692101094373118
shown4077692101093686136202252
in4349692101092171
Fig.4439692101094464115134
4.4592692101094665
The4080706101094594138
Pearson’s4235706101094688130158192241289306337
R45897061010946
between4653706101094893122189232276325
vancomycin4995706101094183132171217291331369388437
concentrations54497061010938851343940720101094083131159187229257276324372406
predictedby4363720101094775118168187226256299349413453
theWINandDOSmodels48337201010925731172062262843403884375105716137007493940734101095093112144
varied4101734101093778105124167215
from0.631433373410109214995167224240284326365
to0.941,4714734101092570127143185230268280
P<0.000150107341010942106158174218263308348
(Fig.537473410109206179126143
5).553373410109416277
The4080748101094596142
Pearson’s4241748101095296139169205255306324357
R46177481010953
between46897481010955101132201246292342
%PE50507481010976124167
produced5236748101095686135187237277322374
by3940762101095091
DOS140507621010955117159200
and4268762101094088138
those4425762101092674123157202
produced4645762101094776124175223263306357
by5020762101094788
other5126762101094574123167196
models53417621010970119169214235269
varied3940776101094387117138184236
from4195776101092556105181
0.8304395776101094564112157203
to4617776101092978
0.9304714776101094564109153199
(Fig.493277610109256889139158
6),511077610109456886
P52157761010947
<0.0001.52817761010952110128175223271314329
Fig.34758701124771125149
1.51458701125070
Vancomycin63059201074587133170213285321358376422
concentration106859201073780127164201247272298340366384429476
measured1560592010772110155185229255292337
and191359201074692137
predicted206659201074672108154172210237274319
by240159201074682
models2499592010771117163201219249
Tab.343301601125093148172
2.533301601125783
Pharmacokinetic661302201074389135161233279317361398418464503530548586
parameters1264302201075198124167239278305342368400
of1681302201075174
vancomycin.1771302201074489136174217290326363382429445
k12,2233302201074322713087063244623173022010716
k2123503022010743239530870632447
–24583022010751
rate2526302201073275101138
constants,2681302201074387134164191235282307339356
kelm3053302201074330953087063223477
–31883022010751
elimination325630220107446381153172218264290309355402
rate3674302201073275102139
constant343312201073780127157183226272297
non-renal,656312201074489136163189226272317336351
kelr1023312201073510563187063223449
–11223122010743
elimination118131220107355472143161207252278296341387
rate158531220107236591128
constant1729312201073578125154180223270295
renal,2040312201072360106151169185
V12241312201074281
–23383122010742
volume239731220107357998143214252
of2665312201074366
distribution274731220107436191117142160205251277295340386
related314931220107246179124150186232
to3397312201072467
lean3480312201071755100146
body3642312201074389135172
mass,3433222010770114143173189
fr547322201072045
–6083222010741
renal665322201072358103147165
fraction.84632220107194587123150167211257272
Individualized1134322201071561105122159177221265309327345379414459
data1608322201074286111153
presented1777322201074267102133169214239274319
as2111322201074271
mean21983222010767104149194
±24073222010750
standard247332220107285395140184228253295
deviation.2784322201074279116134178203220264310325
‡3122322706324
P31613222010739
<0.0001,32163222010750101117157199241277288
||351732270631021
P35533222010739
<0.01,36083222010750101117157193204
§343332706325
P3833322010743
<0.054423322010754107123165204
compared663332201073780152197243269305351
to1030332201072670
population1116332201074691137183201246272290336382
data;1514332201074691117160175
†1705332706324
P17453322010743
<0.0001,18043322010754107123165208251288299
*21203322010735
P21713322010743
<0.0522303322010754106123164204
compared2450332201073881153198244269306352
to2818332201072670
DOS129043322010756115153188
V1101234590984890
k121495345909841153535180572548
k211972345909841201635180572549
kelr249234590984125333518057243755
fr301134590982655
Clm3346345909847683415351805740
kelm361734590984136573518057243778
population37435790984793141187209250279300345392
DOS1374369909855112154194
0.179973702095395388121
0.9214753702095395391128
0.4619523702095395392133
0.003724363702095395393134171207
DOS2374381909855112154197
0.219933822095395394129
1.1214803822095394984118
0.4819523822095395392133
0.7529743822095395392129
0.2133353822095395394129
WIN137439390987092147187
0.219933942095395394129
1.1214803942095394984118
0.4819523942095395392133
0.0032724173942095395393134171208245
0.014335763942095395393129164201
WIN237440590987092147189
0.219934062095395394129
0.7529744062095395392129
0.2133354062095395394129
WIN337441790987092147190
0.219934182095395394129
1.1214804182095394984118
0.4819524182095395392133
0.7529744182095395392129
0.2133354182095395394129
WIN437442990987092147190
0.399924302095395393131
0.7929744302095395392129
fitted3744419098264877107149197
DOS1374453909855112154194
0.208734542095395394132
±1023454209548
0.03‡108845420953953931301218454605623
0.9913644542095395390130
±1512454209548
0.08‡157745420953953931331710454605623
0.3918494542095395393130
±1997454209548
0.14||20624542095395388123218545460561020
0.00423154542095395392133174
±2507454209548
0.000725724542095395393134175212
DOS2374465909855112154197
0.318864662095395393128
±1032466209547
0.4010974662095395392133
1.1813534662095405085120
±1490466209548
0.17§,†1555466209539538812116744666056233152
0.4018424662095395392133
±1992466209548
0.11‡205746620953953881192172466605623
0.8428664662095395394135
±3018466209548
0.3130844662095395393128
WIN137447790987092147187
0.248614782095395394130
±1008478209548
0.03‡,†1074478209539539213012034786056233050
1.2713434782095394990127
±1488478209548
0.22‡,†1553478209539539413316864786056233050
0.4318194782095395392129
±1965478209548
0.06*,†2031478209539539213316121894786056829
0.00423194782095395393134175
±2511478209548
0.001||25774782095395392133169274147860561020
WIN237448990987092147189
0.228604902095395394133
±1011490209547
0.02‡,†1076490209539539313012054906056233050
0.6928684902095395393131
±3017490209548
0.4730824902095395392128
WIN337450190987092147190
0.238595022095395394133
±1010502209547
0.03‡,†1075502209539539313012055026056233050
1.2513465022095394990130
±1493502209548
0.18‡,†1558502209539538812316825026056233050
0.4418195022095395392134
±1970502209548
0.06||,†203650220953953921332169502605610202949
0.8528515022095395394132
±3001502209547
0.33*30665022095395393130161
WIN437451390987092147190
0.468535142095395392133
±1003514209548
0.20‡,*106951420953953931321201514605623301231514209531
0.7228665142095395392131
±3014514209548
0.4030795142095395392133
Tab.340534101124992146170
3.528534101125276
Vancomycin649534601074587133170213285321358376422
serum108753460107337096142213
levels131653460107215997134153182
(VCM),1514534601072673120188210224
%17545346010766
prediction1836534601074874110156174211239257302349
error220153460107406691135161
(%PE),2378534601072689131169193206
RMSE,26015346010745113151188204
Bland-Altman2821534601074664109155201228277295321392437483
bias3321534601074765110140
–34785346010747
comparison354153460107398215419924534054460107264473118164
to521544601072670
measured6075446010772110156186230255292338
values.961544601073882100146184215232
Data12095446010757103129172
presented1397544601074672109140177224249285331
as1744544601074676
mean18365446010772110156202
±20545446010754
SD.2124544601074095110
‡P225154510632422755446010743
<0.0001,23345446010754107123165208251288300
**P2650544601073571114
<0.005,27805446010754107123165208248263
*P3059544601073578
<0.0531535446010754107123165205
compared3374544601073881153198244269306352
to3742544601072770
measured;3405546010771110155185229255292337352
†P7085551063247325546010743
<0.00017915546010754107123165208251288
compared1095554601073781152198243269306351
to1462554601072770
DOS115495546010756115152188
VCM79056830984894161
concentration96856830983681127164206253281310351380401447493
[mg/L]101257830982490137165205227
%PE1689568309867113154
[%]170957830982491113
RMSE2121568309846113155197
[%]216357830982491113
Bland-Altman286456830984668109156203230281302331399441487
bias248757830984768110144
±2647578309848
SD271157830984297
(95%282557830982465108175
limits301657830982142111132161195
of322857830984571
agreement)331657830984187116159201270312359388411
measured371590309868110152186232261303351
24.19585906095397589124
±1099590609548
10.811645906095397589130
DOS1371602309855112154194
20.29406026095397892132
±1090602609548
5.3**11556026095395293123156
−5.715896026095488699138
±1744602609548
34.518096026095398093133
35218160260953976
3.9627466026095395391131
±2894602609548
9.1529606026095395185119
(−14.0–21.9)309760260952167101136150190233269304315352373
DOS2371614309855112154197
21.29616146095397585126
±1104614609548
5.5*11696146095395393122
−3.215906146095488498139
±1746614609548
33.018116146095397791130
33218161460953976
3.2927396146095395394132
±2889614609548
8.7429546146095395493127
(−13,8–20.4)309961460952167101135148189231267306320359378
WIN137162630987092147187
20.69556266095397892132
±1104626609548
6.2*11696266095395495126
−4.4158862660954889103142
±1747626609548
36.418136266095397893131
36218062660953978
3.5527486266095395393130
±2895626609548
9.1729606266095395286119
(−15.0–22.1)309762660952167101135149188231267306320355371
WIN237163830987092147189
20.09406386095397892131
±1089638609548
6.4**11546386095395493123156
−7.415956386095488389128
±1741638609547
36.718066386095397893131
37218263860953975
4.0927496386095395393133
±2899638609548
9.1029646386095395186122
(−13.7–21.9)310363860952167102135149188225260296306344364
WIN337165030987092147190
20.59576506095397892132
±1106650609548
5.7*11716506095395391123
−4.5158665060954889103143
±1747650609547
36.218126506095397893133
36218065060953978
3.6427386506095395393134
±2890650609547
9.2229556506095395192131
(−14.4–21.7)310465060952167101136150189232267303313352374
WIN437166230987092147190
16.79506626095397489128
±1095662609548
6.3‡†11606626095395494125466310562346
−20.8156366260954883121135176
±1756662609548
39.4†182266260953976881271947663105623
44217966260953981
7.4127286626095394685119
±2864662609548
11.4429296626095397181120162
(−15.0–29.8)310866260952167102136149189232267306318359379
Tab.340681001124990144166
4.524681001124670
Vancomycin638681501074485130167209280314350368413
serum106768150107286489134204
levels128768150107155390126144173
(VCM),1476681501072066112179201214
%prediction17056815010761118144180224242278305323367413
error213368150107356085128153
(%PE),2302681501072182123161184197
RMSE,25146815010741107144181196
Bland-Altman2726681501074058102147192218266284309379423468
bias3210681501074260104133
–33596815010741
comparison3416681501073477147191236261279307351397
to340692501072670
DOS14266925010756115153188
model.6316925010771116162201219235
Data8826925010757103129172
presented1070692501074571108139177223248285330
as1416692501074676
mean15086925010771110155201
±17256925010754
SD1795692501074094
%PE1043706209867113154
[%]106371620982491113
RMSE1846706209846113155197
[%]188871620982491113
Bland-Altman286470620984668109156203230281302331399441487
bias248771620984768110144
±2647716209848
SD271171620984297
(95%282571620982465108175
limits301671620982142111132161195
of322871620984571
agreement)331671620984187116159201270312359388411
DOS2371728209855112154197
4.19727285095395388
±1077728509548
13.911427285095397387125
14190872850953974
−0.66274172850954889103143184
±2942728509548
2.4830077285095405392133
(−5.5–4.2)315872850952167105118158199241255296316
WIN37174020987092147
−16.892974050954882117132173
±1119740509548
24.911857405095397589126
30190674050953978
3.4427517405095395392134
±2902740509548
5.0629687405095395292132
(−6.5–13.4)311874050952167109123163205239273287326345
WIN137175220987092147187
1.79717525095394988
±1076752509548
15.211427525095397386127
15190875250953973
−0.42274775250954889103142179
±2944752509547
2.7530097525095395392128
(−5.8–5.0)315575250952167105118159201239253292313
WIN237176420987092147189
−1.49497645095488292131
±1098764509548
15.811637645095397386127
16190776450953974
0.1327777645095395388121
±2916764509548
3.0329817645095395393130
(−5.8–6.1)312976450952167105118159201243258293309
WIN337177620987092147190
1.79727765095394988
±1077776509548
12.711437765095397286125
13190877650953973
−0.33274277650954889103144181
±2940776509548
2.3130067765095395393128
(−4.8–4.2)315177650952167109123163205247261302322
ORIGINÁLNÍ341201012673138172244278352422476549582
PRÁCE944201012661125197257315
COMPARISON34132701063272127163200237255289330373
OF72932701064072
MW\PHARM817327010654113143177219260296352
3.3011843270106344983117
(DOS)131632701062463105138163
AND149532701063981122
MW\PHARM1632327010654114143178219260297352
++2000327010655110
(WINDOWS)212532701062484103145185227287321345
VERSIONS248632701063870107142160202244278
OF277932701064072
PHARMACOKINETIC286732701063576117153209250285324361380422455489508543
SOFTWARE342632701063274106141203241277310
FOR375232701063072109
PK/PD387732701063471100135175
MODELLING406832701065495136169201234252294335
OF441832701064072
VANCOMYCIN450632701063875117153193248285318337379
IN34143501061557
CONTINUOUS41443501063474116150168210252293336369
ADMINISTRATION79843501064080135153195213247280317360389407449492