421
www.klinickafarmakologie.cz340804301076513320121425327329234035839843647950254457164568672477179183988990895196610061045
/26548043010757
Klin2730804301077091109157
Farmakol2907804301074279105179220258305325
Farm3252804301074178105179
2022;36(3):85-923451804301074487128172187231275298341362376420463491535577
/40478043010777
KLINICKÁ41438043010772115136195216269315373
FARMAKOLOGIE4537804301074292139211266313373415475534555599
A51568043010754
FARMACIE5230804301074392140212267318338382
8756558026012657114
ORIGINÁLNÍ4694208012673138172244278352422476549582
PRÁCE5297208012661125197257315
COMPARISON106833401063272127163200237255289330373
OF145633401064072
MW\PHARM1544334010654113143177219260296352
3.3019113340106344983117
(DOS)204333401062463105138163
AND222233401063981122
MW\PHARM2359334010654114143178219260297352
++2727334010655110
(WINDOWS)285233401062484103145185227287321345
VERSIONS321333401063870107142160202244278
OF350633401064072
PHARMACOKINETIC359433401063576117153209250285324361380422455489508543
SOFTWARE415333401063274106141203241277310
FOR447933401063072109
PK/PD460433401063471100135175
MODELLING479533401065495136169201233252294335
OF514533401064072
VANCOMYCIN523333401063875117153193248285318337379
IN466344201061557
CONTINUOUS473644201063474116150168210252293336369
ADMINISTRATION512044201064080135153195213247280317360389407449492
The483650101094699147
formula650650101093486118196248271316
is986650101092966
based10726501010960106143191245
on13376501010958111
the1468650101093789137
assumptions16256501010952891261782563093413633436641010951103140
that503664101093789134165
CL6886641010960104
is812664101092865
related897664101093784107152183229283
to1200664101093788
the1308664101093789136
CLcr14646641010961104146177
and16616641010951103156
CLm18376641010960104182
is343678101092158
linearly420678101092951102149194224247291
related730678101093783106151181227280
to1030678101093787
BSA.11376781010956102157179
CLcr13366781010960103144175
is1530678101092965
calculated1615678101094793115157208230274305351404
by343692101095397
Jelliffe460692101094189112135157185216264
II744692101092952
equation8166921010954108159205236258310363
(9).1199692101093379105123
BSA13426921010957103160
is1522692101092865
calculated1607692101094995118160212235280311358412
according343706101094486127177208260282334386
to749706101093787
Du8567061010968120
Bois9967061010956108130167
and11837061010950102155
Du13587061010967119
Bois14977061010957108131167
(10).1684706101093376120145163
The18677061010952105152
“#vancomycin_adult_k_C2”343720101093072113157204241286358395432451498544592638684704732777819866914958989
model13507201010970119169214235
(WIN1)1603720101092298120178219238
uses1859720101094580124159
renal343734101092975125169190
(kelr)552734101092871115137167191
and762734101094696147
metabolic9297341010977123154198249300322343384
(kelm)1332734101092871115137212235
elimination158673410109487091167188238282311332382433
rate343748101092973102146
constants507748101093785135169200243292321358
instead883748101091867102132176219270
of1171748101094672
fr1262748101092353
or1333748101094675
Clm,1427748101094969143162
respectively.160774810109267110615720224327529533838234376210109216377
The438762101094191135
parameters591762101094790119161235279309352381417
were10267621010961105134178
converted1222762101093684133174217246277321371
by1612762101094687
Formula1718762101093987116190238258301
23437761010946
and408776101094494145
Formula572776101094493123199248270313
3,904776101094765
respectively,988776101092974110161208249281302346391413456471
fr220165650952044
=2260656509547
kelr23226565095336683106
*2442656509532
V1248965650955388
*2591656509532
LBMc263765650953371132166
*2817656509532
1000290965050953985124164
*3135658509531
1.7332296505095394988127
(2)37056505095216080
60295166250953979
BSA322966250953870110
C1m219768450954376136
=2347684509548
kelm24096845095336784147
*2571684509531
V1261668450954075
*2705684509532
LBMc275168450953371132166
*2931684509532
1.8530356785095394990129
(3)37066785095215978
BSA303569050953870110
V12278720101095298
represents2396720101093784137169215253300353383422
the2838720101093789136
volume29947201010951102125176254302
of3316720101095785
distribution342172010109598111815018120325730934036221387341010951104
and22627341010953105158
LBMc24417341010952102178221
is2682734101093067
lean2769734101093078124176
body29657341010961114168213
mass31997341010985131168205
corrected34247341010950101132164211255289335389
for2138748101092778110
fat2268748101093379110
distribution2398748101095981117149180203256308339361413465
calculated2883748101094894116158210232277308354408
according3311748101095193134185216268291342395
to3726748101093788
Chennavasin21387621010952100145195244287328371406426475
(11).2632762101092263100119136
The2786762101094191136
population-based2941762101094797148197218261290310359409437489532567612663
parameters362276210109489112016321387761010975121151196226263
of2420776101095077
all251677610109446586
the2621776101093181127
models27677761010975126177223245280
are3066776101094474119
given3204776101095173116161211
in3435776101092171
Table3526776101094583134156202
2.3747776101094767
The393462101094699146
Marquardt4100621010981127158210262307338391422
algorithm454262101095174126178209232264315393
was4955621010975120157
used513262101095895142196
for534862101093485116
extrapolation.548462101095398393476101093059104155206228271301322372422442
Examples407490101094590135212265288335372
for446690101093384115
graphical460190101095888134186238260302347369
output4990901010957109140193244275
of528590101095785
DOS15389901010968133178221
andWIN33934104101094393143235256315360
models43131041010971121172217239274
are4605104101094069114
shown4738104101093281131196246
in5003104101091867
Add50891041010952102152
Fig.5260104101094161111130
154081041010943
and5470104101094089140
Add39341181010955106157
Fig.4110118101094464115134
2,4263118101094765
respectively.4347118101093075111162208250282303347392413457472
Model39341435014393158225283309
evaluation42701435014360114169194257311347372435500
Concentrations40741601010953104157200247299331362408440463515568605
predicted4700160101095991139193216259293339394
by51141601010960105
the5239160101093891139
“vancomycin54061601010931751231743934174101093987163204243266316
(cont.inf.)4268174101093371119169199219243293320339366
%ahz”46521741010978128179218252
(DOS1)4925174101093496162208252273
and52191741010952105158
“vancomycin54061741010931751231743934188101093989166208249272324
adult”4277188101096411516619022145061881010933
(DOS2)45611881010944108175223271298
DOS48811881010980147195
models50981881010995149205254279318
and54381881010963117172
by3934202101095398
the4053202101093891140
“#vancomycin_adult_k_C2”422220210109327712217022126231038742946949154259264369474476779784689294399610441078
(WIN1),53212021010934116140203248270289
“#vancomycin_adult_C2”3934216101093174117164213253299374413452473522570620669717739768815866913945
(WIN2),48992161010933112135196242267285
“vancomycin_adult_C2”52112161010931741201702092563303703934230101093859109156206255303325354401452498530
(WIN3),44852301010931110133193240264282
and4787230101094899151
“vancomycin_C1”4963230101093173120169208255329369407429478525576618647
(WIN4)39342441010926108133196246272
Windows42282441010988113166221274344382
models46322441010987141196244269307
were49602441010979127159208
compared51892441010952104183238285317366421
with3934258101096891123175
the4130258101093890138
measured42892581010984132178215267298346400
concentration4710258101094899152195242294326357403435458510563
and52932581010952104158
the5472258101093890138
concentration3934272101094089139180225275305335379409430480531
predicted4484272101094879124176197238270315367
by4870272101094991
the4980272101092878123
DOS151232721010957120164206
model.53482721010972122174220242262
All3934286101095678101
models40552861010983135188235258295
were43702861010974121152198
two-compartmental,45892861010937107158190234284362415460491525602649701732778801821
with5430286101097497128180
the3934300101093083131
exception4086300101095399140187241274296349402
of4509300101095886
WIN446163001010985109172221
which48573001010976129152194247
is5125300101092966
one-compartmental.521230010109581111591912372883663934314101095196127160237283335365410433453
Predictions4407314101095484130183205247280302352404440
by48673141010958101
all498831410109507395
models51033141010982133185232255291
were54143141010973119150196
evaluated3934328101094690136159210255286332386
retrospectively.4340328101093784116147198235288336379413435480527550594611
Percentage49713281010956101133175221273304349402449
prediction54413281010959901373934342101095072113146168218269
error4222342101094373104154185
(%PE),4426342101092393142186212230
RMSE,46763421010946119164208228
and4924342101094191143
Bland-Altman5087342101094669113163215244300322353428472523
plot3934356101095174125156
were41103561010966112143189
used4319356101094985132185
for4524356101092677108
prediction4652356101095182128181203244277299350401
precision5073356101095182128171193229251301353
evaluation.54463561010945891343934370101092171114144166216266286
%PE42403701010968116160
was44193701010963107143
calculated4582370101093782103144194216260289334386
as4988370101094076
the5084370101092777123
difference522637010109487097127172203248298339384
between3934384101095096126194239284334
the4287384101092776122
predicted4428384101094877122173195235267311362
and4809384101094090141
the4969384101092676121
measured51093841010971117160195244273318369
value54973841010940843934398101092171117
(Formula4070398101092367116146222272294338
4),442739810109446886
or4532398101094777
as4629398101094177
the4725398101092778124
difference486839810109487097127173203249299340385
between5273398101094895126194239286337
models39344121010977130185233257295
(Formula4250412101093480132164244296320366
5).4637412101095682101
RMSE47594121010958135182228
was50094121010975122160
calculated5190412101094996120163216239286318365420
according3934426101094385126175206258280331383
to4337426101093080
Formula4437426101094595126202253275320
6.4777426101094767
%PE396446020955795129
=4108460209547
predicted42264542095406293133148180203234273
–measured4512454209538113146185210248270301340
(4)55024542095215878
measured439446620956496135161199220252291
%PE396448820955795129
=4108488209547
predicted42844822095406293133148180203234273
(WIN)45704822095208499147165
–4748482209539
predicted47994822095396192131146178202233272
(D0S1)508448220951967104137167181
(5)55004822095215980
predicted45414942095406293133148180203234273
(D0S1)482749420952068104137167182
RMSE396451540953999133167
=4146515409547
14415510309539
×4529515409548
Σ(%PE)245965154095436612647255154095387548065154095214828515805623
(6)55015103095215979
N4415522409549
All407455210109557698
values4191552101094791112162207243
are4453552101094777122
presented4594552101095585130166212262292336388
as5001552101094783
mean51035521010978124168218
±53405521010957
standard54165521010939701151653934566101095194124175
deviation41285661010957102146167211240261311362
(SD).4509566101093274134158175
Due47035661010966116162
to4884566101093685
normal49885661010956106136212255277
distribution52845661010957781131441741952462973934580101093051101151
of4104580101095379
values,4202580101094791112162207243263
statistical4484580101093969114143164200230252292336358
analysis4861580101094696140161204240261297
was51775801010969113148
performed5344580101095510113116021024039345941010977125180
by41345941010963107
using4261594101096198121173226
paired45085941010962109131162210264
Student’s4793594101095585137191239292323346381
t-test.519559410109406799146184216237
The54535941010955109157
Prism3934608101094980103140218
5.04172608101095776125
software4317608101094698126161233279310357
by46956081010961106
GraphPad48216081010969101147201253304349403
Software52446081010955107135170241287318366
was39346221010966110146
used4099622101095490136188
for4306622101093181111
statistical4436622101094171116145166202233254294338360
analysis4815622101094898142163206242263299
(Pearson’s5133622101093078122165195232282332350383
R,5535622101095475
Student’s3934636101094473123174220270300322355
t-test,430863610109305586130166197216
Bland-Altman4543636101094971115165216245301322352427471521
plot).5083636101095174124153178195
Results39346610014768131181249281323375
Best39346895014361120164203
model416468950143100165231290315
selection45076895014346105130188243284308372437
Vancomycin4074706101095296148192243322366408431483
concentrations45787061010955106159202249302334365412443466519572609
predicted5208706101096698146200223266300347402
by3934720101095193
all404672010109476889
models41557201010978128179225247282
are4456720101094776122
shown4597720101093888138204255
in4871720101092474
Fig.4964720101094767118137
1.5120720101095064
Mean52047201010975121165215
concentrations54387201010943921423934734101094288140171203249280302354406443
predicted4398734101095991138192214257290337391
by48097341010960104
the4933734101093890138
models50917341010984136190238261298
were54097341010975122154201
significantly3934748101093658109161182210234276321372402424468
lower4422748101092879146192222
than4664748101093788132183
the4867748101093788134
measured50217481010983130174210261291337390
concentrations54317481010947971493934762101094288141172203250281303355408445
(Table4400762101093585125179202250
3).4670762101095782100
Mean47917621010984132178230
values50417621010954100123175223261
of5322762101096089
%PE54317621010983133179
varied3934776101094387117138184236
from4189776101092757107182
−3.24390776101095599118166
in4575776101092272
DOS246667761010961124168213
to4898776101093079
−20.8%4996776101095496142160209280
in5295776101092272
WIN4.5386776101097799159205224
Add340614011259113167
Fig.52561401124872125149
1.69261401125071
Graphical80861901075379122167214232269313332
output115661901074591117162208233
of140661901074568
DOS11490619010756115153188
model1694619010772117163201220
Add3403640011259113167
Fig.525364001124872125149
2.692364001125076
Graphical813364501075379122167214232269313332
output1161364501074591117162208233
of1411364501074568
WIN31495364501077391145185
model16963645010771116163201219