843
KLINICKÁ341804301074588109168189242288347
FARMAKOLOGIE708804301074392139212266313373416475534555599
A13288043010753
FARMACIE1402804301074292139211266317337381
/18048043010757
Klin1880804301077091109157
Farmakol2057804301074278105179220258305325
Farm2402804301074178104179
2022;36(3):85-922601804301074386128172187231275298341362376420463491535576
/31978043010777
www.klinickafarmakologie.cz4568804301076513320121425327329234035839843647950254457164568672477179183988990895196610061045
861828026012657116
ORIGINÁLNÍ341201012673138172244278352422476549582
PRÁCE944201012661125197257315
COMPARISON34132701063272127163200237255289330373
OF72932701064072
MW\PHARM817327010654113143177219260296352
3.3011843270106344983117
(DOS)131632701062463105138163
AND149532701063981122
MW\PHARM1632327010654114143178219260297352
++2000327010655110
(WINDOWS)212532701062484103145185227287321345
VERSIONS248632701063870107142160202244278
OF277932701064072
PHARMACOKINETIC286732701063576117153209250285324361380422455489508543
SOFTWARE342632701063274106141203241277310
FOR375232701063072109
PK/PD387732701063471100135175
MODELLING406832701065495136169201234252294335
OF441832701064072
VANCOMYCIN450632701063875117153193248285318337379
IN34143501061557
CONTINUOUS41443501063474116150168210252293336369
ADMINISTRATION79843501064080135153195213247280317360389407449492
Statistika:34361101245591146183212256294323378432458
Průměrná82261501216194150234285318375423
procentuální126761501216498153199249306338394443466522546
chyba1834615012153109155213262
predikce211861501216598149207230277322371
(%2511615012136113
PE)2646615012161109138
vypočtená2806615012156107166222268304354410459
jako328761501213180127181
(predikovaná349061501213693127177235259306360408457513562
–4074615012157
změřená)/změřená,4153615012150135186218268325373400433475560611643693750798820
příp.499461501216598122180200
(predikovaná-DOS1)/DOS1,52156150121369412717823625930636134375501214897153202234303374423469491523591661710757773
RMSE,1137755012162143193242263
Bland-Altmanova142175501216287135191248280342366399483532588643691740
bias,218375501216488136176197
Pearsonův2402755012161110158191232288344399448
korelační2871755012155109142193217265311366390
koeficient3282755012155109160190217262285336392425
(R),372975501213589117136
Studentův388675501215789144201252309341397445
t-test.435375501214069102152192226248
Statistická462375501215688137170194233267291336383432
analýza5077755012156112160184232277328
byla5426755012165112136185
provedena34389501215790144192241298348404452
pomocí816895012157113197252297320
GraphPad115889501216497146203259312359416
Prism159589501215385108147230
version184689501214897130171194249304
5.00217189501215271123176
pro236889501215790144
Windows.2534895012184108163220275348387409
Výsledky:3431031012463116159186239299353408435
%7981035012175
PE894103501215097
se1012103501213686
pohybovala11191035012153109164209266321368416439487
mezi16271035012179129172195
–3,21843103501214696115167
±20311035012156
33,02108103501214896115166
%22951035012175
a23911035012145
−7,424571035012156101112163
±26411035012155
36,7%,2717103501214898119168260281
s30191035012136
výjimkou3076103501214495119141224270324378
jednokompartmentového347510350121217112818223728433742047652455759267572578081286591296110161071
modelu45661035012180135191241265319
„vancomycin_C1”,490310350121347612617922127135139343445650956061465969055901035012121
kde3431175012147102152
byla5161175012154100124172
−20,87091175012157103153173226
±9561175012156
39,4%.1033117501214897115166258280
Nejlepší13341175012162113137160210267307330
výsledky1685117501214495134158208265312362
byly20681175012154100124171
dosaženy22611175012153108147196239289344390
modelem26721175012180135192242266316400
„vancomycin3089117501213477127180222272353396437459512
adult“.3620117501214910115417620724438631175012121
Model39051175012177132189240263
„#vancomycin_adult_k_C2“4187117501213482129179232274324405448489511564616670722774797828879926979103410841118
produkoval53261175012154871411982533431315012147101148196220
nejnižší5841315012156107131186209252293316
%9211315012180
PE,10221315012154102123
RMSE11661315012155136185233
and14201315012150105161
Bland-Altman1603131501215579127182238270332355388471519575
bias2199131501215881129168
mezi23881315012185135179202
WIN26111315012186110176
modely,28081315012184139197247271318334
ale3164131501214972122
korelace33081315012147101134184208256301350
byla36791315012158104128176
slabší.3876131501214164112169208231252
Korelace41491315012155109142192216264308357
byla45281315012157104128176
mírně47251315012185108140196247
lepší4993131501212475132171194
u52081315012156
modelu52851315012185140197247271326
„vancomycin_adult_C2“343145501213477127181222273354397438460513565619672724747777828883933967
RMSE13311455012154135184232
byl15851455012157103128
stejný,1734145501214073123147202247264
%20191455012179
PE21191455012154102
a22421455012148
Bland-Altmanova2312145501215478126181238270331354387471519574629676725
bias3058145501215781129168
byly32471455012157104128175
obdobné34431455012156113170225282338389
jako3853145501212472119173
u40471455012155
modelu41241455012183138196246270325
„#vancomycin_adult_k_C2“.447114550121348212917923227432540644949051256561767172377679982988092898110361086112055891455012121
%3431595012179
PE4431595012154101
mezi5661595012183134177200
oběma7881595012154112163246294
DOS11031595012167137185
modely13091595012184139196246270318
byla16481595012157103128176
4,11845159501215171116
±19831595012159
13,9%2063159501215296116165257
(NS);2341159501212893142169188
„vancomycin2549159501213477127181222273354397438460513
adult“30811595012152104157179210248
měl33501595012184134158
mírně35291595012184107139195246
lepší3796159501212374131170193
výsledky4010159501214899139162212269316366
než43981595012155106149
DOS1.45681595012167136185231247
Závěr:3431731012458112163215254280
Z6441735012161
WIN7261735012189114180
modelů9271735012188143201251275330
byly12781735012162108132180
nejlepší14791735012161111135158209266305328
výsledky18281735012154104144167217275321372
dosaženy22211735012161116156205248298353399
modely26411735012189144201251275323
„vancomycin_adult_C2“2990173501213477127181222273354397438460513565619672724747777828883933967
a39781735012153
„#vancomycin_adult_k_C2“.405817350121348212917923227432540644949051256561767172377679982988092898110361086112051771735012121
Oba52191735012174131180
DOS54201735012172142190
modely3431875012183139196246270318
produkovaly682187501215790144201256303357404452476523
nízkou1226187501215679122168222277
bias1525187501215780128167
a17131875012149
jejich178318750121247498121166221
predikce2025187501215790140197220267311360
byly24061875012157103127175
srovnatelné.2602187501214072126173230278310359383438489509
Klíčová343204101246190118163220272325
slova:689204101244371129181234260
PK/PD9692045012153106145199264
modelování,12542045012183139196246270325372421476499520
vankomycin,1795204501214896152198252336381425448503524
Mw\Pharm,23402045012181154188241296344376460481
terapeutické2842204501213382115164220271327360383427474523
monitorování33862045012183139194217250304337392439488543566
léků,3973204501212474121177197
kontinuální41922045012146100156188211266321369393448471
infuze.4684204501212379107163206256276
Introduction3432410014732101143186254325394448493524592661
Vancomycin483258101095093144185235312354395417468
is971258101092359
a10502581010946
glycopeptide1116258101095375119160209262309362393415467514
antibiotic1650258101094697127149201224274305327369
used343272101095087134187
for550272101093485116
the687272101093788135
treatment842272101093869115160191268315367397
of1259272101095785
severe1364272101094491135181212259
infection,1643272101092880107154197230253304356376
with343286101096689120171
its53428610109225391
use645286101095086133
being7982861010952100122173225
limited1043286101092244120142173219272
by1335286101095295
its145028610109225391
nephrotoxicity156128610109519715020223228231336340542834330010109406191136
and499300101094090141
ototoxicity.660300101094676125155204245267307329359404420
Vancomycin1099300101094789139179228303345384406456
nephrotoxicity157430010109479314419522427430435239441634331410109406292138
can501314101093782133
be653314101094996
avoided768314101094184133155207253305
by1093314101094991
therapeutic1204314101092778124154199251297348379400441
drug1665314101094878129180
monitoring18653141010972123343328101094971101150180202252303
(TDM)665328101092371131204229
(1–4).913328101092365107157181199
Vancomycin1131328101094789139180229304345385407457
pharmacodynamics1607328101094999143173248292332381343342101095195147191267290331369
is732342101092763
time-dependent,815342101093759135181213267314366413465517564615645666
which15013421010972124146187238
means17593421010981128173224260
that343356101093081125156
the519356101093788134
clinical67335610109487092143165206251274
outcome9673561010956107139179229305352
is1339356101092865
not14243561010957108138
dependent15823561010958105158205256308355406437
on3433701010950102
the466370101093889137
maximum6233701010984129174197274326403
concentration1047370101094898151193239292323354400431453505557
(Cmax),1625370101093386171137670644471981810370101092644
but18753701010959111143
on3433841010949101
the464384101093687133
time617384101093658135181
above8183841010950102154198243
the1081384101093687134
minimum12353841010981103154176252303379
inhibitory1634384101092778129151204226257307338385
concentration343398101094088137178222271300330373403424473523
(MIC).885398101092292114166193210
The1114398101094191136
clinical126939810109375879129150190233254
effect154239810109426998143184216
can1777398101093780130
be1926398101094793
better343412101095197128161206236
described598412101094894130172202224275322374
by991412101094991
the1102412101092777123
area-under-the-concentration-curve1245412101094070116159189240291342388418444475525571602645694744343426101094084134164193237267288338388417460509539585630
(AUC)992426101092377133185212
where12234261010963113159189234
400–600mg/L1476426101094391139187236283331417468500543
are343440101094373118
required480440101092773124174196225271323
(3).82244010109236891109
As950440101095290
high1059440101094769119170
Cmax1248440101094912974467064436995
is1412440101091854
not1485440101094797128
necessary,1632440101094793135179215251296325371386
continuous343454101094087137166187236285334384419
administration781454101093989163184234254289320349392421442491541
could1341454101093684133155205
be1565454101094792
more16764541010971120150194
suitable1889454101093280101343468101093074126149195
than557468101092878122172
intermittent74946810109196999144175251273303336381432462
dosage.1230468101094999135180231277296
This1546468101094294115151
method17174681010972118149200250302
of343482101094977
administration440482101094799175198249271307339369414445467517569
allows102948210109476991142209246
to1295482101093483
aim1398482101094870146
for1564482101093081112
a16964821010947
higher1763482101095476127178225256
therapeutic343496101093081127158203255302353384406448
range811496101092772123175221
of1052496101094875
15–20mg/L,1147496101094486133177223311363396440461
compared1628496101093888164217262292338391
to343510101093080
10–20mg/L443510101095194144187234322374406451
when9145101010971123169221
intermittent1155510101092677107153184260283314347392444474
dosage16495101010956107144189241287
is1956510101092763
used.343524101095086133185206
The5695241010950102149
target738524101093681112163210241
range999524101093681132183230
can1249524101094691142
be14115241010958105
increased1536524101092778120150197241278324377
to1933524101093686
20–25mg/L343538101094795146191239330384418463
in827538101092982
severe930538101094492138185217264
infection,1215538101092982110158202236259311364385
especially1621538101095392145194238261306330353398
at343552101094476
the439552101093890138
beginning5985521010959108162184237289312364417
of1036552101095786
treatment,1142552101093870117163194272320372404425
with1587552101097599131183
lower1791552101092981149196228
incidence343566101092172114136188234286328373
of736566101095380
nephrotoxicity8365661010953100152204234285316365407430472494525571
(5).142756610109287499117
The15645661010948100146
desired17305661010954101138160190236289
AUC3435801010957116172
can537580101095299153
be7115801010964113
obtained8465801010961116149197220274323378
by12455801010964109
multiplying13755801010989141165198221276301347371424479
the1875580101094195144
concentration343594101094192144187233286317348394426448500553
with916594101097598130182
a11195941010951
factor1191594101093481123157208240
of1451594101095886
2415585941010954100
(3).1678594101093480105124
Even1822594101095398144197
though343608101093081131183234285
the648608101093182129
plateau797608101095275119150196240290
concentration1107608101094291143185230281312342387418440490542
at1669608101094475
steady1764608101093768114158211255
state343622101093668113144190
is553622101092864
in637622101092980
fact737622101093479121154
a9116221010951
straight982622101094375106151173225276307
line,1309622101092951102149168
in1497622101092880
19971597622101095396144189
there1806622101093889136167213
were3436361010966112143189
only5526361010950101123167
two7396361010930100150
computer909636101094090166219270301347378
programs1306636101095283133185216261337373
that1699636101093081126156
were18756361010967112343650101093078
able4426501010952106130178
to641650101093890
handle7526501010958104157211234283
continuous10566501010949100153185208260312365418455
vancomycin1532650101095299152195246325369411434487
administration343664101094396172194245267303335365410441463514565
(6).92866410109277297115
In483678101092272
our5756781010956106136
area,731678101095079125169189
the939678101093687133
treating1091678101093767112156186207258309
doctor,14206781010957107149182231261276
with1716678101097395125176
input19116781010928783436921010953105137
from500692101093465117195
an7156921010952104
antibiotic8396921010951103134157210233284316338380
centre,1239692101094995147178209256276
chooses15356921010948100152204242289327
the1882692101093789137
vancomycin343706101094387137178227303344384405455
initial81770610109227294124145188210
dose.10467061010952102137183202
Vancomycin1267706101095193143184232308349389410460
plasma1746706101095375118154229273
concentration343720101094191143185231283313344389420442493545
measurement9087201010983130175212262293340417464516547
is1474720101092965
recommended1559720101093783126176253331378430343734101095196148
on5107341010950101
the630734101093080126
second775734101093782124172223274
or1068734101095080
third1168734101093080101131182
day1369734101095195136
of1524734101095077
treatment.1620734101093060105149178254299350379399
Vancomycin343748101095092142183231307349388410460
dosage8227481010955105141185236282
is1123748101092560
then1202748101093585130181
optimised14027481010954106136157232253288334386
using1807748101095490111161212
Bayesian343762101094993135179215236280330
modelling,6927621010978129180226248269290340391410
with1121762101097092122172
the1312762101093383129
aid1460762101094768120
of1599762101095379
the1697762101093484129
Mw\18457621010976143174
Pharm343776101094899143173250
36127761010953
:6857761010911
30716776101093986
software821776101094393121154224269299345
(DOS)1185776101093293157201227
(7).1431776101093379106123
A15747761010962
Windows16557761010984107157210260327364
version,2138244101094388118154175225276295
with2452244101096991121171
a26422441010946
broader2707244101095484133177229274304
spectrum3030244101093990136178210240290365
of3414244101095279
models,35122441010978128180225247283302
has2138258101095092127
been2284258101094894139189
available2492258101094081125145166209260282327
since2837258101093353103143187
20143042258101094388130171
as3232258101093974
a33252581010940
response3384258101092670106156206256291336
to3739258101092674
declining2138272101095196138159180230251301352
support2509272101094089141192243273306
of2834272101095380
the2933272101093383129
DOS30812721010964127171
operating32712721010953105151181225255276326377
systemon36672721010939831192138286101092973148212262
the2418286101092676121
later255728610109186190134163
versions2738286101094084113149169218268303
of3059286101094672
Windows.3149286101097394143194243308343362
After3530286101095176109153182
its373028610109184884
release,213830010109297394139182216261279
the2435300101092675120
company2573300101093684158208252301341
had2932300101094689139
decided3089300101094792132153203247298
to3405300101092674
discontinue349830010109466710114118923826728721383141010950100145
the2302314101093181127
development2448314101095197140185207257309384430481510
of2977314101095177
the3073314101093181127
DOS32193141010961124168
version.3406314101094488118155176226276296
As3721314101095693
the2138328101093080126
estimates2283328101094379110131206250280324360
produced2662328101095081130182231272317369
by3050328101095092
the3161328101092979124
available3304328101094285129150171215266288334
WIN3657328101097597157
models21383421010975125176222244279
are2436342101094069114
not2569342101094797127
based2715342101094892127173225
on2959342101094696
our3074342101094796126
population,3219342101094899150200222265294315365415434
and3672342101094090142
they2138356101093080126168
differ2325356101095778105134180210
from2554356101093263112188
DOS,27613561010966129173192
an29723561010950100
assessment3091356101094985120166202238313359409439
of3549356101095582
WIN36503561010982104164
models21383701010976126179225247283
prediction2440370101095889135187209250282304354405
quality28653701010957107151173195225271
for3155370101093383114
extrapolation3288370101095296129159203255307329373403424475526
was21383841010966111146
necessary.23043841010956102144189225260305335381396
Several2719384101095197141185216260281
models30203841010981132184230252287
are3327384101094979125
available3471384101095092137158179223275297343
for2138398101092676106
vancomycin2263398101095094144185234310352392413463
prediction2745398101095888133185206247279300350401
in3165398101092778
both32623981010957108138188
DOS34693981010967130174
and36623981010950100152
WIN2138412101097698158
versions.2315412101094388118155176225276311331
The2278426101094596142
aim2439426101094465140
of2598426101095076
the2694426101093080126
study2839426101093667116168211
was30694261010967111146
to3234426101093180
find3333426101092750101152
the3504426101093080126
best3649426101095298134165
model21384401010975125177223245
for2402440101092878108
vancomycin2529440101094589139180229304346386407457
in3005440101092373
both30974401010953104134184
WIN33004401010978100160
and3479440101094696147
DOS36454401010962125169
versions2138454101094388118154175225276311
of2468454101095076
the2563454101093080126
Mw\Pharm27084541010972138169218267311340416
software.3143454101093686112145214258288333351
Methods21384790014799162206275343414465
Patients21385075014360114149174232296332378
Request2278524101095097151202250287319
forms2617524101093485117195232
for2869524101093385116
routine3005524101093789140172194246293
TDM33185241010953116191
of3529524101095885
vancomycin36345241010952971492138538101094089165207247268319
were24765381010973118148194
used2689538101095692138190
as2898538101095086
data30035381010957101131175
sources.3198538101094292142172213257294313
Twenty35305381010952113158209238284
adult2138552101094395144166196
patients2353552101095599129150196246276312
repeatedly2684552101093479131177221251295347369412
examined3115552101094992136211232282328380
for3514552101093080110
vancomycin36435521010947911422138566101094292171214256278330
concentrations2488566101094899152194241293324355401432454506559596
during31045661010959111142165217270
2016–201933945661010954102146190241285332377420
were21385801010968115147194
included2352580101093183126149200254302356
in2728580101093183
the2831580101094092140
study.2991580101094678130184229245
The32575801010955108156
exclusion34335801010955100142164216254276328381
criteria213859410109417295126172204226271
were24295941010975121153199
fewer2648594101093481150196227
than2896594101093789134185
two31025941010937108158
examinations3281594101095297142220242294339370392444496533
and2138608101094393145
intermittent2302608101092575104149179255276306338383433463
dialysis.2784608101095576119141184220241276295
The30986081010949100146
cohort3263608101094493143193223256
characteristic35386081010944941381672112522138622101093074104126161192213253
is2410622101091954
given2483622101094769112157207
in2709622101091868
Table2797622101094179131153198
1.3014622101094458
The3091622101094293139
initial324962210109186889119140184205
dose3473622101094898134179
was36716221010964108143
estimated2138636101094580111132206250279323375
by2532636101094789
the2640636101092776122
treating2780636101092756101144174194244295
doctor.3093636101094897138170219248263
The3375636101094292138
median35316361010972117169190233283
dose21386501010952103140187
was23456501010974119156
1,625mg/24hr2521650101095368117163211299352384432477541571
(min31126501010933107129181
250mg,33136501010953101148237289309
max36426501010983128172
5,000mg),2138664101094765112161210298350375392
and25506641010950101153
the2723664101093687134
dose/kg28766641010958109145191224268318
was32146641010973118154
19.6mg/kg3388664101095395111159247299331375426
(min2138678101092698120170
0.25mg/kg,2327678101094665113159246297329372422441
max27876781010975119162
58.8mg/kg).2968678101094692112160246297329372422446463
A34516781010955
loading3525678101092171115167188238289
dose21386921010951101136182
of2339692101094773
500–1,000mg2432692101094389137185226241288336384470521
was29726921010964108143
given3134692101094869113157208
to3361692101092776
seven3456692101093379122166217
patients3692692101094893213870610109305196147176213
–23707061010944
to2433706101092877
six252970610109355598
of2646706101094875
them2740706101092878124199
at2958706101094272
the3049706101092878124
commencement3192706101093988163239285335376420496542592622
of2138720101094976
therapy2233720101093383128158202254296
and2548720101094696147
one27157201010952102148
patient2882720101095498128149195245275
(No.3176720101092887137155
20)3350720101094994119
received3488720101093278119164185229274326
a21387341010944
bolus22017341010958109131181216
of2437734101095582
1,000mg2538734101095368115163212298350
on29077341010956107
day30337341010957101143
four3195734101093383133163
(Add3377734101093287138190
Fig.3586734101095071122141
1,3747734101095267
Add21387481010956109162
Fig.2320748101095173125145
2).248574810109547997
Six2602748101095274117
samples2739748101094490167220243290327
from3086748101093466117195
four3301748101093385136167
patients34887481010959105136158205257288326
were21387621010966111141186
taken2343762101093276119163213
by2576762101095295
temporary2690762101093176151203254284328357403
interruption3112762101092373102147177207257309339360410460
of3591762101095278
administration36887621010945972138776101097596146168203234263307337358408458
due26157761010951101147
to2781776101092978
high2878776101095071122172
levels.3069776101092267111155177212232
The4074384101094596142
Ethics4235384101094878128149190227
Committee44813841010956105180256277307339384430
of4930384101095480
University50293841010963113134178222252289310340385
Hospital543338410109631131493934398101095173103147169
Ostrava4122398101096197127157201243287
approved4429398101094293145175224267312364
the4812398101092878124
study4955398101093465115166210
and5184398101094292143
all534639810109426485
protocols54503981010950801293934412101093080123172195231
on41854121010956108
Feb4312412101095197150
21st4481412101095497128160
2019.46614121010953100143185202
Reference48834121010955102130177207253305347392
number52954121010957108184237284315
163/2019.3934426101094688134163210255298339355
Vancomycin39344515014361113177231293391442495520583
analysis45454515014356119173198252297321364
Vancomycin4074468101095296148191242321365407430482
serum4577468101094896128181259
concentration48574681010953104157200247300331363409440463515568
was54464681010980126164
analysed3934482101094496140163207244291344
by42984821010959102
LC-MS/MS44204821010950101125201247278352397
(8).4837482101093379104122
Commercial49794821010960109187264311342383405450472
quality54714821010958109393449610109446587117163
controls4116496101094796147177207257279315
(Roche4450496101093281131173223270
Diagnostics,4739496101096789133184235285321352374415452472
Germany)52304961010965112142219263313355380
at3934510101094474
three4027510101093787117163210
levels4257510101092774118163185221
(low,4497510101093354105172188
middle,47045101010983104156208230276295
and50185101010951101153
high)5191510101095778130180204
were54145101010974119150196
measured39345241010975121165200249279324376
every4329524101094386131161206
day,4554524101094992134149
together4722524101092776127173204254299329
with5070524101096486116166
the5255524101092777123
batch5397524101094993123163213
of3934538101094975
patients’4028538101094791120141186236265301319
samples,4366538101093276151201223268303322
and4707538101094089140
their4866538101092675121142171
concentrations5055538101093785135176219269298327371400421470520555
were39345521010966111141186
in4139552101092172
the4230552101092979125
declared4374552101095197138159203232278329
range.4723552101092973123174220238
Pharmacokinetics39345775014360123177212311365419481532559622681718743796843
analysis48045775014356120174199252297321364
Pharmacokinetics4074594101094796138167242285324372414436485530560581620656
analysis4749594101094089131152194230250284
was50525941010962105140
performed5210594101094893123151200229304349400
by3934608101095193
using4046608101094985106156207
two4272608101092997146
versions4438608101094287117153174224275310
of4767608101094875
the4861608101092979125
Mw\Pharm50056081010971138169217266310340415
software543960810109358511214539346221010967111141187
(MEDI\WARE,41406221010932104149209232264337390439485504
Prague,4664622101095484128179230276294
Czech49786221010959100145187238
Republic/52356221010955102154205257279300341375
Groningen,3934636101096092143196218271324371424444
Netherlands):43986361010969117149201249280303349401455492516535
Mw\Pharm49536361010982151184234286331362441
354146361010955
:54906361010911
305522636101094088
(1997)3934650101092671115165212240
(DOS)41956501010943105171218245
and44616501010961114169
Mw\Pharm++46516501010991160193245297343375454511568
1.3.5.5585240650101096481132152204224275321370
(2016)3934664101092670116159201225
(Windows).41786641010925103126176227277343379402419
The4074678101094495140
clearance4233678101093758103146175219269309353
(CL)4605678101092272114139
of4762678101094673
vancomycin4853678101094084133174222297338377398448
was53196781010963107142
calculated54806781010937801013934692101094090111155185229281
by4234692101095294
Formula4347692101094492122198248269313
1.4679692101094661
CL422772220954376
=4317722209548
CLm437972220954376140
*4533722209532
BSA464471620953872115
+4838722209548
fr490072220952044
*4959722209533
CLcr500672220954174106129
1.8546377281095394990129
CL396475220954376
–4054752209540
represents41087522095235697120153181215256279307
total44297522095236386125141
clearance,45857522095334983124147185227260293307
CLm490775220954275139
–5060752209540
non-renal511475220954181123147172205246286303
clearance,54317522095335084125396476220952361103136169183
BSA416276220955286129
–4306762209554
body437476220955596137171
surface455976220954282105127167200233
area,480776220955477110151165
fr498776220953558
–5060762209554
renal512976220953770111152169
fraction,53127622095355897130155172212254268
CLcr396477220954376108131
–4109772209540
creatinine41647722095335689130153169210227268302
clearance44817722095334984124147186227261293
Tab.3940243501124992146170
1.4128243501125070
Patient4243244001074386112130167214239
characteristics4498244001073884129154197234262299324342372398416453485
mean5077257709868110152198
±5292257709847
SD535625770984197
Age397126970985197139
(yrs)41272697098246595129152
66514727000953979
±5244270009548
12530927000953973
Gender397128170985396143190232262
(male/female)425028170982490132153195223249291360402423465488
13/7519428200953973100141
Weight3971293709870110131178224253
(kg)424029370982566111134
85514829400953978
±5243294009548
16530829400953974
Height397130570985496118164211239
(cm)422730570982458127149
170.0507730600953972110124163
±5258306009547
10.853233060095397589129
Serum397131770984284113160228
creatinine421631770983665107149177198244265312354
(μmol/L)458731770982470139185206234274298
112513331800953970104
±5254318009548
70532031800953976
Site39713297098426391133
of412032970984572
infection42083297098216794136173203224270317
lung397134170982167113160
14522834200953974
blood397135370984768114161209
19522835400953973