527
www.klinickafarmakologie.cz340804301076513320121425327329234035839843647950254457164568672477179183988990895196610061045
/26548043010757
Klin2730804301077091109157
Farmakol2907804301074279105179220258305325
Farm3252804301074178105179
2022;36(3):85-923451804301074487128172187231275298341362376420463491535577
/40478043010777
KLINICKÁ41438043010772115136195216269315373
FARMAKOLOGIE4537804301074292139211266313373415475534555599
A51568043010754
FARMACIE5230804301074392140212267318338382
8556558026012657115
https://doi.org/10.36290/far.2022.01445195940106335476111136151177197471459201083876964808594010615476710112649345920108377290129165202238276301326363388405443480516553572609644679
ORIGINÁLNÍ4694208012673138172244278352422476549582
PRÁCE5297208012661125197257315
COMPARISON106833401063272127163200237255289330373
OF145633401064072
MW\PHARM1544334010654113143177219260296352
3.3019113340106344983117
(DOS)204333401062463105138163
AND222233401063981122
MW\PHARM2359334010654114143178219260297352
++2727334010655110
(WINDOWS)285233401062484103145185227287321345
VERSIONS321333401063870107142160202244278
OF350633401064072
PHARMACOKINETIC359433401063576117153209250285324361380422455489508543
SOFTWARE415333401063274106141203241277310
FOR447933401063072109
PK/PD460433401063471100135175
MODELLING479533401065495136169201233252294335
OF514533401064072
VANCOMYCIN523333401063875117153193248285318337379
IN466344201061557
CONTINUOUS473644201063474116150168210252293336369
ADMINISTRATION512044201064080135153195213247280317360389407449492
Comparison3409300298143276481623748837900100311401279
of16679300298138219
Mw\Pharm193593002982033834605977338589471151
3.3031359300298133192330459
(DOS)3643930029875236408534603
and34011900298127265407
Mw\Pharm795119002982033834615977338589471151
++199511900298143284
(Windows)2327119002987528935349263377094810491115
Versions349111900298152267358461525662801903
of34014500298138219
Pharmacokinetic6081450029813927640149069481992510601189125613951520160816731779
Software243614500298129267348439624749838963
for34481450029882219308
PK/PD380514500298139282367505668
Modelling4522145002982033414836086747388029401079
of34017100298138219
Vancomycin60817100298153270408515650855974107811431281
in19381710029866204
Continuous21911710029814327641550056570484197811161219
Administration345917100298157296501565704767870956104811711257132214591598
Marcela3402108013793152194243301332390
Hricova1,7522108013776118148197260317375111921170803611542108013729
Blanka1205210801376697155219279337
Koristkova1,15652108013767128170200248288349411467525208221170803651
2,214621170803621842108013729
Eliska2235210801375990120167227286
Vavreckova1,25432108013770125181223281331391453510568310421170803631382108013729
Ivana3189210801373189147211269
Kacirova1,34812108013767125175205247311367425389821170803651
2,396221170803640002108013729
Hana40512108013776134198256
Brozmanova1,43292108013767109173224319378442505562620494221170803651
2,500621170803650432108013729
Milan3402258013793124154212276
Grundmann163922580137751171812463114064645285931224226708036
1Department3402419078333712412013373129191244280319410465526561
of955241201336192
Clinical1071241201336388113173198247300325
Pharmacology,14192412013359118171206297350399457483543605658675
Faculty21172412013354102151211236272326
of2466241201336192
Medicine,25822412013388144206231280305365420441
University30472412013371131156208262298342366402457
of3527241201336092
Ostrava,36422412013376119156191244295348370
Ostrava40362412013376119156191244295347
2Department3402569078333732562013373129191244280319410465526561
of957256201336192
Clinical1073256201336388113173198247300325
Pharmacology,14212562013359118171206297350399457483543605658675
Institute2119256201332687129166191227286322376
of2518256201336192
Laboratory26342562013352106168229265318353412448503
Medicine,31602562013388144206231280305365420442
University36252562013371131156209262298342367402457
Hospital41052562013372133175237263298352377
Ostrava,45052562013376119156191244295348371
Ostrava48992562013376119156191244295348
Objective:3402930012472134163217264304333388440467
For8292934012149104138
a9892934012149
long1060293401212481137194
time,1277293401213357141193214
the1513293401213490141
Mw\Pharm16762934012181155191245300349383468
software2166293401214096126163240290323374
suite2562293401214096120154204
(MEDI\WARE,27882934012129109159226252287369427481532554
Prague,3364293401215487136193249301322
Czech37082934012158104155202258
Republic/Groningen,39882934012154106164220278303327373410473508563620644700757809865887
Netherlands)48972934012167118153209260294319368424482522548
has54672934012156105145
been3403069012157109161218
used580306901215494145203
for806306901212884117
PK/PD9463069012152105145200266
modelling12343069012182138197248273297321377434
in1691306901212278
therapeutic1791306901213288140173223281333389423447493
drug2306306901215589145202
monitoring25303069012183139195219254309343367423480
(TDM).3033306901212780148230257277
The33323069012148106157
aim3511306901214771156
of3689306901215383
this3795306901213188112151
study3969306901213873129186235
was42263069012172122162
to4410306901213287
find4519306901212855111169
the4710306901213288139
best48723069012155107148183
model50773069012182138197248273
in5372306901212278
the5473306901213187139
newer3403204012155107181232266
Windows6283204012185111167224280354395
version1045320401214999133174198254311
of1378320401215686
Mw\Pharm++14863204012182156191245301350383468528589
1.3.5.5582097320401215269124145199220274323375
(WIN)24943204012130117142209237
for2754320401213086120
continuous28963204012146100157190214271326382439479
administration33973204012149107191215271295335370404453487511567623
of4043320401215586
vancomycin.4151320401214998155201255340387431455512534
Patients:3403339012153101135159210267300342363
Twenty7253339012150118169225259309
adult10573339012148106162186220
patients12993339012157107141165216273306347
with1669333901217498132189
a18803339012148
mean19513339012183135184240
age22143339012148105157
of2393333901215585
6625003339012152105
±26283339012160
122710333901215196
years,2829333901214797147180221243
body30953339012157114172221
weight33383339012174124149206262296
8536563339012151103
±37813339012160
163863333901215299
kg,3984333901213995117
and41233339012149105162
median43083339012183135193217266323
dose46533339012157113153204
1,6254880333901215168121171223
g/245125333901214985137186
h53333339012148
were54033339012174125159210
repeatedly340347401213383142194243276326385409458
examined820347401215199148233257313364423
for1265347401213086120
vancomycin.1407347401214999155201256340387432456512534
Methods:3403605012485140178239299360405432
Concentrations7943609012166121178224274331365398448482506562619659
predicted14753609012165100150209233279316366424
by19223609012165112
“#vancomycin_adult_k_C2”,206536080121348213018123627933141345749952357763068573979281684890094910031060111111471168
“#vancomycin_adult_C2”,3252360801214189137188243286338420464506530584637692746799823855907963101410501071
“vancomycin_adult_C2”,434336080121418814019423728937141545748153558864369775077480685891596610021023
“vancomycin_C1”5385360801214189140195340374301214294176219262285339392448494526
WIN8883744012187113179
models10903744012186142200251276316
and14283744012151107165
“vancomycin1618374301213481133187230281363407449473527
(cont.inf.)2164374301213171122177208229254308337357385
%ahz”25683743012180134188230267
(DOS1)2856374401213198168218265287
and31653744012151107165
“vancomycin3355374301213481133187230281363407449473527
adult”39013743012154108161185217256
DOS41793744012169140189
models43913744012186142200251276316
were47293744012177127161212
compared49633744012147102186244294327378437
with54223744012176101135191
the340387901213389141
measured5033879012184136185225280314365423
values948387901214999123179230271
and12413879012149105163
with14263879012175100134190
the1638387901213490142
DOS118023879012167138188235
model.20593879012184140199250275297
Statistics:340401001245491146183212257295324371416443
Percentage8054014012151100134179229286319369425477
prediction1304401401215488139197221267303327383439
error1765401401214882116171205
(%PE)19924014012126104158207236
calculated2250401401214392117162218242291325375433
as2705401401214686
(predicted-measured)/measured281340140121268411716822625029633238244047355861065969975478783889692595810401091114011801236126913201378
or4213401401215386
(predicted-DOS1)/DOS1,43214014012127841181692272512963333834414745436136637107327658339039539991016
RMSE,53594014012151133183232254
Bland-Altman340414901215479128184242275337361395480529585
bias,947414901216286135175197
Pearson’s11674149012157107156189231287344364401
coefficient15914149012149104156186220247293317368425458
of2071414901216090
rank2183414901213787143191
correlation23964149012149104138172223248297330354410467
(R),2885414901213387116135
Student’s3042414901215487142200251308341367404
t-test.3468414901213867101151192227249
Statistical3739414901215486136170194233268292338388412
analysis41734149012153109158183231272295335
was45304149012179128168
performed47204149012162114148181237271356407465
using5208414901215999123180237
the5467414901213894145
GraphPad340428401216599148206263317365423
Prism785428401215487112152236
version1043428401214999133174198254311
5.001376428401215273125179
for1577428401213187120
Windows.17204284012185110167224280354395417
Results:3404415012459113158218247285331357
%PE7194419012187141189
values9314419012155104129184236276
varied12294419012156105139163214273
between15244419012164116150227278330386
−3.219334419012166117138192
±21474419012167
33.0%22364419012159108129182263
and25214419012155111169
−7.427124419012167114126178
±29124419012167
36.7%,30014419012159110132184263286
with33104419012180105139195
the3527441901214197148
exception36974419012158106151201259293317373429
of4149441901216292
“vancomycin_C1”,427044180121348113318723028136340744947352757963568271349824419012121
the5025441901214096148
only51954419012162119143191
one-54094419012162118170204
-compartment340455401213179133217275324358394478530586619
model,9814554012181137195246271292
where12954554012171128179213263
it1580455401212255
was16574554012172121161
−20.818404554012157104155176229
±20914554012158
39.4%.2171455401214898117169247270
The24634554012148105156
best26414554012154106147181
outcomes28444554012153109143187242326377418
were32844554012171121155205
achieved3511455401214691147171222270320378
with3911455401217196130186
“vancomycin4117455301213481132186229280362405447471525
adult”.4661455301215010315618021125049104554012121
The49534554012147104155
“#vancomycin_adult_k_C2”5128455301213482129180234277328410453340468801214266120172227281334358390442491545601652687
model10504689012188145203254279
produced1351468901216296152210266312362420
the1793468901213894146
lowest1961468901212884158209249284
%PE,22674689012184138187209
RMSE,24994689012158140190239261
and27834689012153109166
Bland-Altman2972468901215984133189247279342366400484533590
bias3584468901216186135175
among37814689012153137194250307
the4111468901213894145
WIN42784689012190115182
models,44824689012188145203254279319341
but48454689012162118153
its5020468901212862104
correlation51464689012150104138172223248297330354410467
(Pearson’s340482401212882131180214255311368389426
R)788482401215280
was8904824012172121161
less1074482401212172113153
tight.1249482401213155112169202224
RMSE14954824012152134184233
was17504824012172121161
the1934482401213187138
same2094482401213888172224
in2340482401212177
“vancomycin_adult_C2”2438482301213481133187230281363407449473527579634688741765797849905956992
while34514824012172129153177228
%PE37014824012177132180
and39044824012146102160
Bland-Altman4086482401215277126182240272335359393477526583
bias4691482401215579128168
were48814824012172122156207
similar,5110482401213862146170194243277294
with5426482401217296130186
slightly34049590121406488145201234259307
better6694959012162114148185235269
correlation9604959012149104138172222247296330354410467
when14494959012178134186243
compared17144959012149104188246296329380438
to2174495901213893
“#vancomycin_adult_k_C2”.2294495801213482129181235278329412455497521575628682736789813845897946100010561107114334344959012121
The34774959012154111163
%PE36624959012183138186
value38714959012152101126182233
between41264959012161113148225275327384
the4532495901213894145
two46994959012138115170
DOS48914959012171142191
models51044959012188144202254279318
was54454959012177127167
4.1340509401215173119
±4815094012161
13.9%564509401215298119169250
(NS);836509401213095145174193
“vancomycin1052509301213481133187230281363407449473527
adult”15985093012153107160184216255
produced1875509401215892148206262308358416
slightly231350940121416589146202236260308
better26435094012158110145181232265
outcomes29315094012155112146191245330382422
than3375509401213490139196
DOS1.35935094012167138188235252
Conclusion:3405225012459117176223252311356384443503529
“vancomycin_adult_C2”889522801213481132186229280362405447470524576631684737761792844900951986
and18975229012146102159
“#vancomycin_adult_k_C2”2076522801213482129180234277328410453495518572624679732785809840892941994105011011136
produced3234522901215588144201257303352410
the3666522901213187138
best38265229012154106147181
outcomes40295229012153109143187241326377417
between44685229012155106141217267319375
WIN48655229012182108174
models.50615229012181137195246270310332
Both54155229012152108142197
DOS3405364012167137187
models5495364012184141199250275315
produced886536401215892147206261307357416
lower1324536401212581155205239
bias1585536401215883131172
and17795364012149105163
their1964536401213490142166200
prediction2186536401215892142201225271307331387444
was26525364012174124164
comparable.28385364012146101185243293326376433459510531
Key3405530012461113164
words:5255530012476133171231275301
PK/PD8475534012153106145199264
modelling,11325534012183139196246270293316372428448
vancomycin,1602553401214896151196250334379423446501522
Mw\Pharm,21455534012181154188241296344376460481
therapeutic2647553401213388138171220277328383416439484
drug3152553401215689144200
monitoring,33745534012183138194217250304337361416472493
continuous3888553401214598154186209265319374430469
administration.43785534012148105188211266289328362395443476499554609630
Porovnání3405810012458115153212264323376435462
Mw\Pharm8235810012484160194252310363401487
3.301330581001245682140195
(DOS)15455810012432100173226256
a18225810012452
Mw\Pharm18955810012484160194251310363401487
++24025810012460120
(Windows)25425810012431121149208268326401445473
verze30365810012453104143191244
farmakokinetického3301581001243487125211264319376430459518572609638683738790849907
softwaru42295810012443101136175253306344403
pro340595001246098157
PK/PD5175950012458119155214283
modelování8205950012486144205258286344396449508536
hladin1376595001245987140200228286
vankomycinu16835950012453106165219276362413457486544603
aplikovaného23065950012453113141169223280332385444497557615
v29415950012453
kontinuální30145950012454111170207235294352405433492520
infuzi3554595001242786121179227256
Účel3406115012468113166194
studie:554611501244481140201228282307
Mw\Pharm8836119012181154188242296344376460
software1364611901214196125161237285318368
(MEDI\WARE,17536119012129107157223247281362420473523544
Prague,2318611901215485134190245295315
Czech26546119012159103153199254
Republic29296119012155105162218274299321366
/33166119012135
Groningen,3372611901216599153209232287343394449470
Netherlands)38636119012167117151206256289313361416473512537
je4421611901212575
dlouhodobě4517611901215780136191246301359414471522
používán50606119012157113169212235283332387
pro5468611901215890145
PK/PD3406254012153106145198264
modelování6256254012181136194244268323370419474497
pro1143625401215588143
terapeutické1307625401213180113162218269325358381426472521
monitorování18496254012181137192215249303335390437486541564
hladin2434625401215477125182205260
léčiv2715625401212272118141189
(TDM).2925625401212779146226253272
Cílem3218625401215678104154238
práce3477625401215588136181230
bylo37286254012155102126181
najít39306254012154102125148182
nejvhodnější41336254012153104128176232287344400450474513536
model46906254012181136194244268
pro4979625401215588143
kontinuální5143625401214598154186209265319367391446469
aplikaci3406389012148105129152198248292315
vankomycinu677638901214896151198252336381425448503558
v12566389012148
novější13256389012156111158207231270293
Windows16396389012185109164221276348388
verzi2048638901214897130175198
Mw\Pharm++22676389012181154188242296344376460519579
1.3.5.5582867638901215167121141195214268316366
(WIN).32546389012129115139205233251
Pacienti:3406520012458110155184237296333361387
207486524012152103
dospělých8726524012157112152208259283330374429
pacientů13236524012157106151174224280312367
(průměrný1711652401213086119174258308341397442
věk2174652401214998145
6623416524012152104
±24666524012161
122548652401215397
let,2666652401212475108129
hmotnost28176524012156139194227282338377411
8532496524012152102
±33736524012160
163454652401215399
kg),3574652401213994121140
bylo37356524012158104128183
opakovaně39406524012156113161208262309358413463
vyšetřeno44246524012149100139190223256305361416
na48616524012157105
hladinu4987652401215680128184208263318
vankomycinu.53266524012149971531992533406659012183129173195251305326
Medián6876659012177128185208256311
dávky10196659012153101147195245
byl12856659012154100124
1625g/24h.14306659012148112161212280315366415482503
Koncentrace19546659012151105161205254310342375423468517
vankomycinu2492665901214593148195248332377421444499554
predikované3067665901215386136193216263316363412467517
pomocí36056659012154110193248294317
WINmodelů39436659012181105171272327384434458513
„#vancomycin_adult_k_C2“,44746658012134821291792322743244054484895115646166697227747978278789269791034108411181139
„#vancomycin_adult_C2“,34067930121348212917923227432540644849051256561767172377679882988093598510191041
„vancomycin_adult_C2“,1399679301213376126180221272353396437459512564618671723746776827883932967988
„vancomycin_C1“2405679301213376126180222272353396437459513564619665694
a31216794012147
DOS31906794012165135183
modelů33956794012182137194245269323
„vancomycin3738679301213477127181222273354397438460513
(cont.inf.)4270679301212766117170200221244297325344371
%ahz“46596793012177130183224260
(DOS1)4940679401212893163211257278
a52396794012148
„vancomycin53076793012134771271812222733406928012181123165187240
adult“5986928012152105157180211249
byly8686929012157104128175
porovnány10646929012157113146201248304352407453
s15386929012140
naměřenou15996929012155103186237268318374429484
hodnotou21046929012156111168224279311365421
a25466929012148
DOS126156929012167137185231
modelem.28676929012184139196246270321404426
KORESPONDENČNÍ33774070954092133171210249303355407445496542593610
ADRESA96574070954799140178216262
AUTORKY:124574070954795134186227268311322
PharmDr.158574070954082119143209261286297
Blanka19007407095405894137171209
Kořístková,212774070953982106123153179213256292329343
Ph.D.,24887407095408297150163177
blanka.koristkova@osu.cz26827407095456299142176214229264306330348377404438480516554612656686728743779814
Oddělení33775270955499143182200239282299
klinické6547527095335269112128165199237
farmakologie,9097527095215882149185219262280323368385424437
Ústav136475270955079105142178
laboratorní15597527095175398142166204228270294338355
medicíny,1931752709566106150167203220263298309
FN225775270953787
Ostrava236275270955484110134172207245
17.3377647095397279
listopadu433764709517346389131176213258300
1751764709539
790,80776470953270110124
70894876470953977117
52108276470953977
Ostrava117676470955485111135172208245
Cit.42087407095466388103
zkr:43287407095336792108
Klin44537407095405976118
Farmakol45897407095377094160197231274291
Farm48987407095377094160
2022;36(3):85-92507674070953977115154168207246268306325338378416441480518
Článek45907527095466399142182216
přijat48237527095456986103139164
redakcí:500475270952462107144178213230243
13.52657527095397387
5.536975270953953
2022543975270953978115154
Článek44847647095466399142182216
přijat47177647095456986103139164
k4898764709534
publikaci:495076470954487131149166200238274291305
15.52727647095397386
7.537676470953945
2022543976470953978115154