937
www.klinickafarmakologie.cz340804301076513320121425327329234035839843647950254457164568672477179183988990895196610061045
/26478043010732
KlinFarmakol2698804301077091109157209246273347388426473493
Farm2020;321180430107326995170224267308351367
34(4):3598804301073579104145167181
152–1573799804301073472114157196233275
/40948043010757
KLINICKÁ41718043010771114135194215268314372
FARMAKOLOGIE4564804301073383130202257304364406466525546590
A51748043010745
FARMACIE5239804301073483130203257309329372
15756558026012657110165
ORIGINÁLNÍ4694207012673138172244278352422476549582
PRÁCE5297207012661125197257315
Comparison182336501063271125160197232250282323365
of220236501063970
DOS228736501063980112
and241436501063980120
Windows254936501065876117156197256289
version285336501063768104139155196238
of310636501063970
the319036501063172104
MwPharm3309365010653112147187227263317
–3641365010646
a3702365010639
pharmacokinetic375636501063374114149204245278317353371412443477495529
software430036501063272103137199236271303
for461836501062971107
PK/PD47393650106346997132171
monitoring492536501065393135152184223259277318357
of529736501063970
digoxin53823650106385695136171189230
patients34361301195599127145191242270306
>669613011954
6574361301194388
years,85161301193985127153189204
including107561301191667109128178230248299352
thosewith144661301192677129163210297316344395
pre‑186161301195078123153
served34375301193784111157203256
systolic61975301193578113143193212230272
function91175301192476127169201219270322
and125275301194394147
at141975301194270
higher150975301195169121172219246
serum177575301193581108160239
digoxin34389301195574128181222241293
concentration,657893011951102155198244297325353398427446498551567
digoxin124589301196180133186227246298
reduces156489301193682137189232278314
HF1899893011970115
hospitalization3431033011953104139191210238281300318356400427446496547
but9101033011950101129
has1059103301194891125
no1204103301194899
effect132310330119426694140183214
onmortality1556103301194899195246274306349367385413458
or343117301195381
all‑cause44411730119436280108153197247281328
hospitalizations7921173011951103138190209237281300318356400428447497549583
[16].1395117301192567108132146
Due4831313011964117164
to668131301192778
the767131301192779127
fact915131301192268112144
that1081131301192779123152
during12541313011950101130150202255
routine1531131301192576128158178230278
TDM18301313011942107183
we3431453011973122
focus488145301193488134188225
prioritally736145301196394115169200221253299321342387
on11451453011962117
a12841453011954
safety1360145301194693119168200248
(avoiding1630145301193578123176198253274328383
overdose,343159301195498146175229283320369385
revealing750159301193784130178222243263316371
non‑compliance),11431593011961115169201248300382437459479524577622669693707
the1873159301193892141
one‑compartment3431733011953107155187234285367422468497531612661714743
(pharmacokinetic)1108173301192681135179208290335380431474496548597628648692717
mo‑18471733011981134167
del,3431873011954102123139
used504187301194985133188
by713187301195295
MwPharm,8291873011974145195247291320401418
is1268187301191853
thus1343187301192780132168
sufficient1532187301193485111141162206226274327356
for1909187301192375104
these343201301193184133170218
purposes,5832013011952105134190244281329366383
even988201301194590138191
though1201201301192780134187241294
pharmacoki‑15172013011952106150179261306351402444466497
netics3432153011954102133153198236
of601215301195076
digoxin699215301195171126179221241294
is1015215301191854
better10912153011952101132165212241
described13542153011951100137182211231286335391
by1767215301195295
the1884215301192881130
two‑compartment3432293011931105158190237288370425471499534615664717746
(PK/PD)1111229301192776124164215278302
model14352293011982135191239260
[5,171722930119277388
17].1827229301194989118133
In483243301192174
the579243301192982131
context732243301194294147177223267301
of1055243301195177
our11542433011951104133
finding,130924330119244699153173226281298
a16292433011943
major16942433011980125145198228
li‑194424330119193970
mitation3432573011980100129173202221272324
of688257301194974
this78325730119267897131
study935257301193363115168210
should1166257301193384136187207259
be1446257301195198
acknowled‑1565257301194184124178229299319366419449
ged.3432713011954103158176
A5402713011964
small6262713011942123167188208
sample856271301194288170224246294
size1172271301194262102149
in1343271301192679
a14442713011950
subgroup1516271301194293148203232284337392
of1930271301195884
infants343285301192175101148201231270
and6352853011954107163
pregnant820285301196393141197251296350380
women12222853011981134217266320
(one1564285301193585140189
infant1775285301192983109156209239
or343299301195383
pregnant448299301196392140195249293347376
woman)8462993011980133215260313337
which12052993011979133153198251
is1478299301192865
a15652993011952
common16392993011953104186268322375
problem343313301195788142199222272357
of723313301196290
studies836313301194680135192213263302
in1161313301192984
diseases1269313301196385122173219257308347
with16393133011982104137192
low1854313301193085159
incidence.343327301192173117137191239291335381397
Although762327301195475105158210263317369
there1153327301192780128156203
is1378327301191752
a14523273011941
PK/PD1515327301194694134184246
target1783327301192772100153201231
for343341301192679108
digoxin,473341301195979133186228249302319
a8133413011950
comparison8853413011949100182237283311332368422475
of1382341301195884
two14883413011935109162
different1672341301195979105135183212259312342
versions343355301194593122160180233287323
of688355301196187
the797355301193992141
same960355301194591173222
software1204355301194498124159234280309356
package15823553011963109154196242297346
is1950355301192864
still34336930119387193114135
lacking501369301192975121164188242298
[18].822369301193581125151167
This10123693011955112133170
makes12053693011991138181230268
it1496369301192961
difficult1580369301196384112143165211266287319
to1922369301193992
analyze343383301194598143164208250298
the662383301192881130
results814383301192673110162182213251
with1087383301196990120173
respect1282383301192774111165214260293
to1597383301192779
efficacy.1698383301194571101122166212257303316
Diversion343397301196586131179208246266319373
of738397301196187
data8473973011962107137182
(especially,1051397301193480117172221267287332352373417429
difference1503397301196182108138186215263316361408
in1933397301192881
the214161301193184133
PK229661301195199
of241761301195480
digoxin251961301195676130183225246299
and284061301194699153
its30156130119225391
high312861301195575129182
concentrati‑333261301194597150195242295324353399429449480
ons2141753011952105140
in230275301191668
children239175301194091111130183211257309
and272175301194092145
pregnant288775301195179125179230274325354
women)3262753011967118198246297320
taken360375301192671111157209
into214189301192174103154
account231789301194690133184237290320
by265889301195699
a2779893011945
model2846893011982136191239260
is312889301192157
necessary.3207893011953102147194231268314343390403
Conclusions21411150014771137206261292361411442510580630
Thedigoxinmodel2281131301194697141207223273322360378426519568619664681
in2980131301191463
theWindows3061131301192473118211229277328377444478
version3557131301193881107140157205255
of2141145301195376
theMwPharmsoftware2236145301192575121211280327376418443523573623646678749792818862
suitewas311714530119318097125169253296330
validated.3465145301193982100117168210236280332347
Based2141159301195296131178232
on23931593011959111
available2524159301195194138156174217271290337
evidence2881159301195498117170217269312357
and32581593011951103156
our34341593011959111138
study3591159301194373125178221
results,2141173301192973107156173200235249
we24091733011966110
conclude2538173301193886136178195244295340
that2897173301192474115142
there3058173301192474119145189
is3266173301191447
no3331173301194797
significant344717330119314898148165188206247290339365
difference214118730119567498126172199244296339384
between25451873011961108137210257304356
quality29211873011959110153172190218264
of3204187301195983
prediction3307187301196189134188206249280298350402
of3728187301195983
plasma2141201301195572113146223264
levels2423201301191459100144161193
of2634201301194669
digoxinbybothTDMsoftware2721201301194764114164202219268334374440490516566623685758807856879910980102210471090
packages,21412153011956100142182226278325360374
their2535215301193687133151178
%PE27322153011979127170
were29212153011978124150195
comparable.3136215301194999179232275302345398417463477
DOS36322153011970136180
andWIN2141229301194595147242261321
versions2481229301194085110145162212262296
of2796229301194871
the2886229301192576121
s/w3026229301193265133
suite317822930119328198126170
can3367229301193982132
be3518229301195096
used3633229301194881127179
for2141243301192676102
TDMof22622433011944106181250273
digoxin2554243301195169120170209227276
interchangeably.284924330119186894138164204254296346397442484535554595604
In2281257301192173
general,2376257301195199151200228274294310
variations2708257301194187115136180209229282335371
in3101257301191769
results3192257301192673109161181211249
occurred3463257301194994136189217247294348
with2141271301197293123176
the2339271301192780129
same2490271301193379160209
immunoassay2720271301191899180232284338383420456502544
processed3286271301195281133178224261297346401
on37092713011949103
different214128530119547499128175204250302331
analysers,2493285301194294137158201237285313350367
as2881285301194277
well29802853011967114135154
as3156285301194177
using3254285301194984104155209
different348428530119507096125172200247299328
TDM21412993011946112189
software2352299301193386112147221266295342
packages.2716299301195297141183229283332368386
In3124299301191870
case3216299301194187123171
when34092993011969122170223
blo‑3654299301195273126158
od21413133011952106
samples2268313301193378157210231278314
from2603313301192251101181
the2805313301192779126
same2952313301193378157204
patient3177313301195195124144190242270
are3468313301194169115
every3604313301194487134162208
time2141327301193153136186
analyzed23493273011954108154176221265313370
in2742327301192882
different2847327301196384111142191221270324354
laboratories,3224327301192975131187217264295347378399449487505
it3751327301192961
may21413413011984130174
increase2338341301192983129159208253291341
an27023413011954108
amount28333413011954138193247302332
of3188341301196289
the3300341301193994144
possible34673413011964120158196216272295345
laboratory‑based2141355301192268125181212260291344375424455513561599650707
errors.2871355301195788119173204243262
These31563553011956112163202252
apparent34313553011955111168216246295350381
and2141369301194699153
marked23163693011990135164206254309
differences2647369301196283109139187216264317362409446
in3115369301192881
SDC32183693011954117175
may34153693011989135177
have36143693011961106150198
significant2141383301193860116172194221245291339395426
implications25903833011933117175198219266314345367423479517
for3130383301193994125
patient32783833011968117148170221276307
care.36093833011957105136185203
Clearly,2141397301195778127171200222266279
there2442397301193892141170218
is2682397301192864
considerable27683973011953104158195215269318347394449470519
potential33093973011963118148195248278299343364
for3695397301193487117
confusion393961301194598153179234271292346401
or436261301196292
dosing4477613011963117155176230285
error.478561301195787117170201214
Accurate5022613011967112155209239286316364
TDM5409613011955122201
remains393975301193080165212234289327
essential4290753011961100138189245276298344367
to468075301194397
ensure4800753011961117155209240289
appropriate5113753011958115173204258316347370416448497
concentrations393989301194596149194241294323352398428448501555591
are455289301194574122
maintained.4696893011981126147199229274294347396451468
Consequently,40791033011957108162198247302354403456485506550562
it4663103301192555
should4740103301194194147200221275
be50371033011958108
considered5167103301194899153189209263311340388443
if3939117301192147
routinely4008117301193789143174194247296317361
using4391117301196197117170225
updated46381173011961115171216246293348
versions50081173011953100130167187240294331
of5361117301196087
the5470117301193891140
same3939131301193783164213
TDM41731313011943109186
software4381131301193386113147221267295342
always4745131301194262134179222259
brings5025131301195281102155209245
benefits52911313011952101154203229250280319
to3939145301193182
patients4043145301195399129149197250280318
–43831453011948
not44531453011951104134
only46091453011951105125169
in4800145301191972
case4894145301194288124173
of5089145301195177
MwPharm,51881453011975147197249294323405422
but39391593011955108139
also4100159301194666102155
other4277159301195484137185214
packages.45131593011956101146188234289337374392
As4927159301195997
a50461593011946
result,5114159301192976113165186216234
future5370159301192680111164193240
research3939173301192977114162207235278331
is4292173301192258
needed43721733011955104153208257312
to4706173301193284
gain48121733011955100120173
a50071733011947
better50761733011956106136170217246
under‑53431733011955108162211240267
standing3939187301193769115168222242295349
of4310187301195380
this4412187301193084104140
thema.4574187301193084132214259276
Author39392130014776144186255323367
contributions43322130014755122191233276307377446489520588657707
TP:40792293011948101119
manuscript42212293011992139194249287334364386443475
writing47192293011982113136168190245301
and50442293011954109166
literature523322930119305183132163211242297327377
search;3939243301193784127155197249264
BK:4224243301194694113
manuscript43582433011977121173224259302330351404433
writing4812243301196896117146166218271
and5104243301194193146
literature527124330119173666112140184213265293339
search;3939257301193786130159202255270
MG:42312573011978140157
study4410257301193769122176221
design;46532573011954102139159213266282
IK:495725730119217090
study5069257301193769122176220
design53112573011955103140160214267
Conflict39392830014771137206240274305359405
od43702830014768140
interest45362830014732101142204248310361404
statement4966283001475194157199260363426495537
The40792993011946101150
authors4251299301194294125178232261299
declared4572299301195199145165210239286341
no49352993011950104
potential50602993011952107136183236266286330351
con‑5433299301194192146177
flicts393931330119264968111143181
of4140313301194974
interest423531330119176896142170216251282
with4538313301196787117168
respect4727313301192671107160208252284
to5032313301192777
the5130313301192678125
research,5276313301192571107154197225266318334
authorship,3939327301194595125176228256293344363416430
and/or4390327301194192145180226255
publication46663273011950101154175194236280309328380432
of5119327301194873
this521332730119267897131
article.5365327301194168101121164183230245
Funding39393530014761127196266298367436
The40793693011946101150
authors42513693011950102133186239269306
received4579369301193481127173194239286342
no49423693011958112
financial5076369301193052104149202247267311332
sup‑5430369301194193147180
port39393833011956112143178
for4140383301193488119
the4282383301193994144
research,4448383301193887125175221251295350367
authorship,48383833011954108140195250280319373394450467
and/or53273833011954109165202252283
publication39393973011955108163184204249294324344397451
of4412397301195379
this4513397301193184104140
article.4675397301194674108129173194242258
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1.34343800853648
Kang40943810833568107146
JS,5704381083275972
Lee65743810833569104
MH.777438108357102115
Overview90843810835083118139174189224275
of119843810834160
therapeutic12734381083256398120153192227265288303335
drug162343810834163101140
monito‑177843810836199138153175212235
ring.3434481083213674113126
Korean4854481083347294128159197
J698448108324
Intern7374481083155375108130168
Med.2009;92144810835489129142178212248283296
24:1–10.12324481083346678108141172203216
2.34345800853652
Rogers40745810833573113148169196
NM,61845810834398111
Jones7444581083226099133160
TE,9194581083316578
Morris101245810835290112134149175
RG.12024581083337892
Frequently13094581083304983123160195233255270302
discordant16264581083365177109146167205238275297
re‑19384581083185275
sults3434681083266379101129
from4874681083204279137
therapeutic6404681083236196117150189225263285301332
drug9884681083396099138
monitoring114146810835997136151173210232247285324
for14814681083195779
digoxin:15754681083395493131162177215227
clinical18184681083324863100115147180196
confusion34347810833168107125164190205243282
for6404781083185678
the7334781083226095
prescriber.8434781083396094121153175190229265286297
Intern11554781083155374108129168
Med133847810835590129
J.148247810832537
2010;153447810833569100132145
40:16944781083347083
52–56.179347810833467101135169183
3.34348800853651
Proost4104881083355693132158182
JH,6074881083267183
Meijer70648810835691106121156177
DK.8984881083478398
MW/Pharm,1012488108356113136172209242263321334
an136148810833472
integrated14484881083165476110149170203225259298
software17624881083276685110163196217251
package34349810833972104134167206241
for6004981083175476
drug6914981083375897136
dosage84249810833775102135174209
regimen10664981083205493108166201239
calculation13214981083306378110148163195217232270309
and164549810833169108
therape‑17684981083205994115148187223246
utic3435081083375974105
drug4635081083355694132
monitoring.61050810835592130145167203224240277315328
Comput95350810833773131169207229
Biol11975081083334885101
Med.131350810835185124137
1992;14655081083316196128140
22(3):16205081083326683116133144
155–163.17795081083326193128159189223235
4.34351800853651
Fuchs40851810833269101139165
A,58851810834155
Csajka65851810833967100115145179
C,85251810833952
Thoma92051810833271109167200
Y,113551810833443
et119351810833356
al.12645181083314659
Benchmarking133851810833570108140178236269290320337375414
therape‑17675181083215994115148187223246
utic3435281083375974106
drug4645281083365795134
monitoring61352810835492131146168204226241279318
software:9465281083236180105158191212245258
a1219528108329
review12635281083185284100134185
of146352810833554
available15325281083296193108123155194210245
compu‑179252810832865123162200222
ter3435381083225577
tools.4355381083225997113139153
Clin6035381083405570108
Pharmacokinet.72653810833573105126185217249286317333371406428442
2013;118353810833468100130141
52(1):13405381083346784116131142
9–22.149853810833471103138150
5.34354800853650
Ponikowski41254810833572110125155193244271301317
P,74454810833943
Voors80354810833975113135162
AA,98154810834487101
Anker109754810834583113147168
SD,12815481083358091
et138854810833759
al.14625481083365164
2016154154810833872103135
ESC169154810833670110
Guide‑181754810834785100139174197
lines3435581083153068103130
for4885581083226081
the5855581083256398
diagnosis6985581083425789128167205232246272
and98655810833573112
treatment11145581083254781113134192227266287
of141655810834161
acute149255810833668106128162
and166955810833674113
chronic17975581083357394132170185217
heart34356810833873104126150
failure.509568108318516682119140174186
Eur7115681083326990
Heart81656810834580111133157
J.98956810832436
2016;104056810833569101132144
37:11995681083346777
2129–2200.12915681083346695130167199233267304316
6.34357800853550
Pagana40557810833566104135172204
KD,6235781083327888
Pagana72657810833263101133170201
TJ,9425781083295061
Pagana101857810833263101133170201
TN.12345781083297587
Mosby’s133657810835189114152183197221
Diagnostic15725781083425788126163201226249264295
&1882578108335
La‑19315781083286182
boratory3435881083397799132154191212246
Test6055881083316289112
Reference.7325881083357089123144178217249282295
14th104258810833364110658850491335
ed.11555881083347387
St.12575881083315266
Louis,133858810833068106121147160
Mo:151458810835391104
Elsevier;16335881083324773108140156190212225
2019.18735881083336899130140
7.34359800853645
Aonuma40459810834178117154212245
K,66459810833651
Shiga7305981083347287125158
T,90359810833443
Atarashi9615981083426396117150177215230
H,120659810834558
et128059810833557
al.13525981083334962
Guidelines14295981083458398137172188203240275302
for17475981083195778
thera‑18415981083236196117150172
peutic34360810833974112135150182
drug5406081083396098137
monitoring69260810835897135150173210231247285324
of103160810833857
cardiovascular11036081083326586124139177209242269301339354386407
drugs15266081083386098137163
clinical17046081083324762100115147180195
use19156081083376499
of34361810833756
blood4156181083365290128168
drug5986181083355795134
concentration74761810832965104136169207229250283305320358396
monitoring115861810835593132147169206227243281319
(JCS14936181083164182115
2015)16246181083316597127145
–1784618108333
Digest18326181083435897132159182
version.21414381083326687114129167206219
Circ23754381083405576108
J.249843810832436
2017;255043810833468100129139
24:27044381083346678
581–612.279843810833468100133170200230243
8.214144800853652
Malhamé220944810835487102140172230265
I,249044810831528
Gandhi253344810834578116155193208
C,275644810834154
Tarabulsi28254481083346283116155194209235250
G,309044810834558
et316444810833457
al.32364481083334861
Maternal331244810835688110144165204236251
monito‑357944810835896135150172209233
ring21414581083213776115
and227245810833876116
safety24044581083326585120143177
considerations259745810833774114141156195231253286309324363402429
during304245810834482104120158198
antiarrhythmic32564581083377698114147168191230261286325384400432
tre‑37044581083274984108
atment214146810833254112147186207
for23644681083236183
fetal24624681083245981114129
supraventricular260746810833169108130163195229267289311326358396412444465
tachycardia.30884681083276092130161193226247285301333346
Obstet345046810835292119142176198
Med.366446810836095135148
2019;214147810833468100130143
12(2):22994781083356482116134146
66–75.246047810833470107139172184
9.214148800853548
Medicare,220248810835488127142173205226259270
Medicaid248748810835286125139171203217256
and275748810832966105
CLIA28774881083366782123
programs;30144881083365794132153185242268279
regulations33084881083185290127142174195210247284310
imple‑363348810831269107122157179
menting214149810835791129150165202240
the23964981083195791
Clinical25024981083375267104119150182197
Laboratory271449810832962100138160192213250271304
Improvement303349810831269108129166197231288322360381
Amendments342949810833895130167205263297334356383
of214150810833757
1988221350810833667102137
(CLIA)--HCFA.23655081083216092107148167190213259300333371385
Final27665081083344987119135
rule29165081083236177112
with30435081083536891129
comment318750810833471129187222260282
period.34845081083417798113151191204
Fed370450810833468108
Regist.214151810833570110125151174188
1992;57(40):7002-7186.234451810833464100133145180213230263299317329362395432465485516549580615628
10.21415280085366882
Kennedy223452810833568104141175213244
JW,24925281083207786
Carey25925281083366888121151
RN,27575281083327688
Coolen286052810833671109124157194
RB,30685281083326779
et316152810833052
al.32275281083284254
Evaluation32955281083296092106142173194208245282
of359152810833452
preci‑36575281083355688120134155
sion21415381083263975112
performance22675381083356888108144164220251287318350
of263153810833351
clinical2696538108327415491104134166180
chemistry28905381083276396152166190212232264
devices.31685381083346798112143175200212
YEEC.33945381083316495133145
1999;35535381083305992126137
1–8.37045381083306196108
11.21415480085366679
Zhou224054810833876115153
H,240854810835063
Wu2486548108363100
G,260254810834962
Hu268054810834987
X,278354810834357
et285554810834062
al.29325481083385366
Pharmacokinetic301454810834078110132190223255293323340378413436451484
Properties35135481083416199139174196221236271298
and214155810833270110
Tolerability22665581083387289124145178218234249264287321
of260255810834363
Cycloserine268055810834573105121159186221243259297332
Following30285581083377591107145196212250290
Oral333355810835375108124
Administra‑347255810834685143159197212238262284317340
tion21415681083223775114
in227056810832058
Healthy234356810835085117132155193224
Chinese25825681083458399137172199234
Volunteers:28315681083417793131169191225260281309321
A3168568108346
Randomized,322956810834174112151189248263292326366379
Open­362356810835392128166189
‑Label,21415781083215588128164180193
Single-23495781083385391131146182205
and257057810833775115
Multiple‑Dose270157810836098114136152191208243266314353380415
3-Way313257810834062120152183
Crossover333157810834566104131158197229264285
Study.36325781083385998137170180
Clin21415881083405570108
Ther.226458810833372107128139
2015;241858810833468100130141
37(6):25745881083346683116134146
1292–1300.27355881083346498132166197227261297310
12.21415980085366884
Yan224459810833565103
L.236259810833549
Pharmacokinetics242659810833976108130188220253289320336374409432447479507
of294859810834160
cycloserine302359810833569100115154180215237252290325
in336359810831956
rats34355981083245779106
by355759810834273
HPLC­364659810834783114153166
‑MS/MS.214160810832177110135190223236
Med239260810835590129
Chem.253760810834077112170184
2015;273660810833468100130141
5(2):28926081083345286104116
104–107.302360810833466102139170201234240
13.21416180085366883
Proost22386181083355693132158182
JH.24356181083236881
Performance25316181083346889110148170228261299331364
of291161810833655
an298161810833169
iterative3065618108314367091124146161194228
two‑stage330861810832174112135162185218257292
Bayesi‑36156181083356898133160174197
an393943810833169
technique40234381083185284121158173211248282
for43204381083165374
population440943810833573112150165196218232270308
pharmacokinetic473143810833674106126184216247283313329367401423438469
analysis52154381083296698113144170185210
of544043810833453
rich55084381083183365102
data39394481083387092125
sets.40794481083266184111125
Pharm421944810833573105126185
Res.44194481083357097111
2006;454544810833468105140153
23(12):47134481083346987119148166178
2748–2759.49074481083346797133170202235267300311
14.39394580085366985
US404545810834476
FDA.413645810833883123138
Bioanalytical42904581083405694127165198213245270286318351366
method467245810836398120159197237
validation,49254581083367085100139172194209247286299
guidance52394581083448197136168207239273
for55274581083246283
industry.39394681083155392129155179200234244
Biopharmaceutics.41984681083365189129167199221279311344377415438453485512526
2018;473946810833569100131144
1–44.489846810833467104141153
15.39394780085366983
Palmer40434781083356783141176197
KG,42564781083408396
Lebin436847810833771110126164
JA,45474781083307084
Cronin464747810834566103142157195
MT,485847810836093102
et497647810833961
al.50534781083375265
Crataegus51344781083456699121154189229267293
mexi‑544347810836298129145167
cana393948810833266106139
(Tejocote)40944881083256294110149183221244279298
Exposure440848810833972113154181220242277
Associated470248810834776104143177193226249284325
with50434881083577497137
Cardiotoxicity519648810834680103142158197220258290306339355379414
and393949810833270109
a4063498108336
Falsely41144981083376682108143158190
Elevated43194981083375287119152174208247
Digoxin458149810835065104142173188226
Level.482249810833670102137152165
J5002498108329
Med504649810835894133
Primatol.51944981083406076134166188225241253
2019;546349810833872104134147
15(4):39395081083346482115132144
295–298.409850810833569103139171205240253
16.39395180085366984
Vamos403651810833566123161187
M,423851810835265
Erath43185181083295082104141
JW,44745181083227989
Benz457851810833267104133
AP,47265181083387378
et481951810833153
al.48875181083294456
Meta‑Analysis495851810835286108140162203240272287318345360385
of535851810833553
Effects54265181083304968101134157185
of393952810833755
Digoxin40095281083425795132162177214
on423752810833572
Survival43245281083296686120135167199214
in455352810831148
Patients4616528108332638499133170191218
with48495281083476284121
Atrial4985528108337587994125140
Fibrillation51395281083304482103118133147179200214252289
or544352810833455
He‑55135281083407597
art39395381083325378
Failure:4032538108332627792130151185197
An424553810834179
Update.433953810834483122155176210222
Am457753810834199
J4691538108324
Cardiol.47305381083407394132148186201214
2019;496053810833468100130143
123:51185381083346499110
69–74.524453810833468105137167180
17.39395480085366876
Jelliffe4030548108324597590105125144178
RW.422354810833593103
The434154810833272107
role44635481083205773108
of458654810833756
digitalis46585481083375291106129162177192218
pharmacokinetics489154810833977109131189221254290321337375410433448480508
in541454810831452
con‑548154810833168106129
verting39395581083326687112127165204
atrial4158558108334557792124140
fibrillation4313558108319367596112127142174196211249288
and461655810833371110
flutter4742558108318357395120153175
to493255810832360
regular50075581083235796134149181202
sinus52255581083274280118144
rhythm.53845581083236192116155212226
Clin39395681083405570108
Pharmacokinet.406256810833573105126185217249286317333371406428442
2014;451956810833468100131143
53:46775681083346779
397–407.477156810833467100133170206238244
18.39395780085366985
Hornestam404057810834482104143178204228260318
B,437457810833548
Jerling4437578108325608197112150189
M,464157810835569
Karlsson47255781083356990106132159197235
MO,4976578108355102114
et510557810833457
al.51775781083324861
Intravenous‑5253578108315537596129161195233271309336357
ly393958810831547
administered400158810833372130145183198224247281302336376
digoxin43925881083405594132162178216
in462358810831654
patients46925881083417495111145183205233
with49405881083526890128
acute508358810833466104126160
atrial5258588108334557792124140
fibrilla‑5413588108318357496112127142174197
tion:39395981083213674112124
a4078598108329
population412259810833674113151166198219234271309
pharmacokinetic/pharmacodynamic4446598108336741061271852172482853153313694034254404714985355736056266847167487848238558939259829971028
ana‑54895981083296799121
lysis3939608108315467388113
based40686081083356894129168
on425160810833573
the43396081083195792
Digitalis44466081083435896111133166181196222
in468360810831249
Acute474860810833869106129162
Atrial4925608108339598196128143
Fibrillation50836081083304483105120135150182203218256294
trial.5392608108319405688103115
Eur55236081083306687
J3939618108324
Clin39786181083405671108
Pharmacol.410261810833572105126184217249286302314
2003;443261810833468104137149
58(11):45966181083346887119147161173
747–755.47846181083356597129161194226238