871
KLINICKÁ341804301074588109168189242288347
FARMAKOLOGIE708804301074392139212266313373416475534555599
A13288043010753
FARMACIE1402804301074292139211266317337381
/18048043010757
Klin1880804301077091109157
Farmakol2057804301074278105179220258305325
Farm2402804301074178104179
2020;2601804301074386128171187
34(3):2807804301074489113156177191
99–1073018804301074488136175214255
/32938043010757
www.klinickafarmakologie.cz4568804301076513320121425327329234035839843647950254457164568672477179183988990895196610061045
1001278026012657111170
ORIGINÁLNÍ341207012673138172244278352422476549582
PRÁCE945207012660124196256314
Hodnocení34136501063980120161202237269310328
geriatrických68536501063768104122162190226244278314353386427
interakcí11273650106165789121157199234267284
lék–nemoc14263650106306298142183214269310345
u1787365010638
seniorů184036501063263105122163199239
v2095365010636
dlouhodobé214736501063869108149190231271312348380
ošetřovatelské254336501063871102136172212250286315347378413448480
péči30393650106336499116
v3171365010636
České32233650106336599134166
republice340536501063366101141177209227261293
Evaluation340543012453106159187245299336364423482
of84254301245893
geriatric955543012458112151178231268308335381
drug‑disease135654301245998157216250312340384437491535588
interactions196454301242887124177216269314353382440499543
in252754301242787
seniors263454301244397156184242281325
in297954301242887
log‑term308654301242786145179216269308395
care350154301244598137190
in371254301242786
the381854301243797150
Czech3989543012459107161207266
Republic4276543012459112173232293321349395
Introduction:34071301242888124164222283342387426455513572598
Prescribing95771701215385135174219252275332356411467
of144371701215584
non-geriatric1546717012156111166199257308340364412444477501545
dosing,2110717012157112151174229285306
inappropriate243771701212177125181238271326383416440487520569
indications302771701212277133157201250283306361416455
and3501717012149104160
drug-disease368171701215689144200232291314353404452491541
interactions424471701212176108158191239284319342397453492
in475771701212277
older485371701215579135186218
patients5091717012156105138161211267299340
cre‑545071701214477127160
ate34085701214881130
specific49185701214399150196219248274319
areas83185701215184134182221
of107685701215584
high-risk118485701215679135190222256280319365
prescribing157385701215790140180225257281337361416472
in206685701212782
geriatrics2172857012156106139163210243275299344384
that257885701213691139171
often277385701215584121170226
lead302085701212677125182
to322385701213690
drug-related333785701215689144200232266316340388420470527
complications,3885857012148101185242266289334382415438493549588609
particularly4518857012157105138174197242296320368400424471
in501185701212681
polymorbid5116857012157113137184269324357414437494
older34099701215579135185217
patients575997012157105138160210266298338
using93199701215594116171227
polypharmacy1176997012156112136183240296344376459507552601
and1795997012148103159
having1972997012155103149172227283
higher227399701215578134188239271
degree2562997012156106163195244295
of287599701215583
frailty.297999701212660108131154186236252
The3249997012149106156
European3422997012149103135189246297345400
project383999701215790144167217263298
SHELTER4155997012149113162208251300353
(Services452999701212572122154205229273322361
and4908997012148103159
Health5085997012165115163186219274
in538099701212075
the547699701213084135
Elderly340113701214972129179212236283
in644113701212277
Long-TERrm7401137012147102157213245291341394427511
care,1270113701214493126175195
7th14841137012152153511430711952
FP,1608113701214798107
2009–2014)17351137012151101154206259305355402448474
aimed2228113701214872155205262
at2510113701214880
describing26091137012157107147192224248304328383439
comprehensive3067113701214599182239272322378428484523546594643
characteristics37291137012145100148180229274309358391415454488511556596
of4344113701215584
415644471137012152116160211
long-term4679113701212277132189220254303336420
care5118113701214593126176
seniors5313113701213990145168223256297
(including340127701212851106151174229285309364420
drug778127701215689144200
prescribing996127701215790140179224257280337360416472
habits)14861277012155103160183216257282
in1789127701212075
718821277012152
EU19521277012149112
countries2082127701214598154209241274297347387
(Czech2490127701212581126176221276
Republic,27841277012154105162217274298321365387
Italy,3192127701212154102126173189
Germany,33991277012165116149233281336381397
Netherlands,38141277012166117150205256289312360416472511533
Finland,4365127701214871126149197252309330
UK,47131277012164119142
France)4873127701214979127183228277302
and51931277012148103160
Israel.537412770121216092141191215236
This3401417012150106129168
study529141701213973128185232
focuses783141701212883129183223273313
on11161417012155111
retrospective1248141701213281115147202241298349395430453501550
analyses18191417012148103151175222262312352
of2191141701215584
drug-disease2295141701215789145201233292315354405453492542
interactions2858141701212378110160193241286321344399455494
in3373141701212378
the3472141701213388138
Czech36311417012158102152198253
sample3905141701213988171228252302
of4228141701215484
seniors4333141701213989145168223256296
of4650141701215584
the4755141701213287138
SHELTER49131417012149114163210253303356
project.5289141701215790144168219264299321
Methods:3401553012485138176236294355399425
Semi-implicit7881557012149100183207238263346402427449494517550
method13611557012184134168223278335
(evaluation1717155701213178125174197252300332355410466
of2206155701215584
complex23121557012146100184240264315362
protocols2697155701215790144177231277331355394
of3114155701215584
geriatric32211557012156106139162210243275299344
patients35881557012157105138161211267299340
from3949155701213165119203
the4173155701213590141
Czech43371557012158102152198253
sample4611155701214291174231255305
of4939155701215584
the5044155701213590141
European52081557012149103135190247298346401
project340169701215689143166215260295
SHELTER,6521697012149113161207250299351374
June-August1043169701213691145195228288341397451489523
2019)15831697012151100146191217
was18171697012173121159
used1993169701215593143200
to2213169701213083
retrospectively2317169701212978111143196235291341386421443491539563609
analyse29441697012147102149172219258308
the3272169701213084134
prevalence3423169701215689138185232255305360404452
of3893169701215483
drug-disease3993169701215688142198229287310348398445484534
intereactions4547169701212074106155187236284328362385439494532
using5097169701215493115170225
expert5339169701215096153203236271
explicit340183701214995151174196240262294
criteria.65018370121457699131179210233280300
Mainly9671837012179126148202225271
Beers12541837012154103153184224
criteria149418370121447698130178210233279
20031790183701215199151199
and20061837012148101157
2012,2179183701215199145188207
Czech24031837012157101149194247
national26671837012155101133155208263309332
consensus3016183701214496150188237292329382421
of3453183701215482
potentially35521837012156110142190244276298344367389435
inappropriate4008183701211973120175230262316371403426472504552
medications45761837012182132187210253301332354408462500
2013,5093183701215099145188207
STOPP/5316183701214998164216267294
START3401977012149100155208259
criteria619197701214577101134183216240287
version927197701214897130170193248304
I.1252197701212345
and13171977012148104160
IPET1499197701212376124175
criteria1695197701214477100133183216239287
have20021977012156104151200
been22221977012157108159215
applied.24571977012148105162186209259316337
In2816197701212378
the2915197701213388138
SHELTER30741977012149113163209252302355
project,3449197701215790145169219265300321
seniors3791197701213989145168223256297
were41081977012174123156206
assessed4334197701214888127177217256306363
using4718197701215594117172228
comprehensive4967197701214598182239272321377428483522545593643
geriatric3402117012156106139163211243276299344
assessment707211701214988127177217256339389445477
(RAI-LTCF1206211701213083146170202252295351398
vers.I)1628211701214897130170192217244
in1894211701212580
101998211701215198
regionally2117211701213585142165220276324347370418
different2558211701215780109142192225275330363
Czech29442117012158103153199254
(CZ)3219211701213186143172
long-term3412211701212681137193225259308341425
care3858211701214796128178
facilities4057211701213280125148171194227251301340
(N4418211701213196
=45372117012160
49046202117012152101154
seniors,4795211701214292148171226259299320
age51392117012148104154
65+,53172117012151101159174
all551521170121487195
patients3402257012157106138161211267299340
residing701225701213686126149205228283340
for1062225701213287120
long-term1204225701212782138194226259308341425
(more16502257012132112167200250
than1921225701213792140195
321412257012151
months)22172257012183139194227282321346
in2584225701212782
evaluated2691225701215097146169224272305354411
long-term3123225701212783138194226259309342425
care3570225701214897129179
facilities).3770225701213382126149173196229252302341366385
For41762257012152106139
statistical4336225701214377126159182221255278322371394
analyses,47522257012151107155178226265316355376
descriptive51532257012156107146191224247304337360408457
statistics340239701214073122155178217251274319359
has7202397012156104143
been8842397012157108159215
used,1120239701215594145202223
namely13642397012156104187237261309
chi-square16942397012145100123154194251306354386436
(χ2)2151239701212976125151
test2323239701213382122155
and25002397012148103160
Fisher´s2681239701214971110165216249276310
exact3012239701215098146191226
tests3259239701213383122156197
(p3477239701212885
<35832397012160
0,05).3664239701215171123173200218
Results:3402533012459111154212239276319345
The7022537012149104154
highest873253701215577132186235274307
prevalence1197253701215688137184231254303358402450
of1664253701215482
potentially17632537012157111143192246278300347370392439
inappropriate2222253701212074121176232265318374406429476508556
drug-disease2795253701215687142197228286308346396443481530
interactions3346253701212074105154186233277311334388442480
(64.33847253701212573125145198
%)40612537012179103
was41812537012173120159
identified4360253701212075125179211233262287336393
using4770253701215492115169224
Czech50112537012157101150194248
national52762537012155102134156210265312334
consensus340267701214599154193244299338393432
of790267701215584
potentially8922677012157113146195251283306354378401448
inappropriate1361267701212176124180238271325382415439487519568
medications19472677012184134192215260308341364419475514
201324792677012151101148193
(CNC),2693267701212581146204234252
then2966267701213086136192
by31762677012157103
Beers32972677012154105156189229
201235442677012152102149193
criteria3755267701214577101134183216240287
(60.24064267701212574126146200
%),42822677012179105123
STOPP/START44232677012150100167221273301350400455508559
criteria5000267701214577101134183216239287
version5305267701214998131171194249305
I.340281701212445
(44.5407281701212573127147201
%/52.96262817012179113162211232282
%,9262817012179101
respectively)1048281701212979119175226272307330378427451499525
and15912817012148104160
IPET1772281701212174122174
criteria1963281701214578101134184216240288
(30.22272281701212574125145198
%).24882817012180105124
The26302817012149106156
most28042817012183138178212
prevalent3034281701215689139187235258309364397
prescribing3449281701215790139179224256280336360415471
problems3938281701215790144202226276359399
were43552817012173123155205
(according4581281701212671115159213245302325380436
to5038281701213084
CNC):51402817012158123181211230
longterm5391281701212075131187340295701213382115199
use563295701215594145
of731295701215584
benzodiazepines8392957012157108163206261318342389433483540564619669709
(BZDs)1569295701213184138204243268
in1859295701212581
depressive19632957012157107164197247286325348397446
patients24322957012157106139162212268300340
(7.8279429570121318192145
%),29622957012180105124
constipation31072957012147101157196230253309358390413468524
caused3652295701214896151190241298
by39742957012157103
opioids41012957012155112135190214270310
without4434295701217498131186241296329
using4787295701215594117172229
laxatives-lact‑5037295701212674121169202225273322362392417465510545573
ulose340309701215579134173223
(7.358530970121298091144
%),7523097012179104123
long-term896309701212580136192224257306339423
use1342309701215594144
of1509309701215584
BZDs16153097012154108174214
in1850309701212480
patients19523097012157106138161211267299340
suffering2313309701214195125158208241264319376
from2710309701213064118202
syncopes2933309701214189145190244301352392
and33473097012148104160
falls3528309701213180103126165
(13715309701212976
and38133097012148103160
more39953097012184139172222
falls4238309701213079103126165
in4424309701212580
the4525309701213489140
past46873097012157106145179
348883097012152
months)49623097012184139194227282321346
(6.35329309701213079100154
%)55053097012179105
and3403237012148103160
long-term521323701212479135191223256305338422
use964323701215594145
of1130323701215584
Non-Steroidal12353237012166122177210257289338371425449505553577
Anti-Inflammatory18333237012161116149172204229285314340388471555603635689722772
Drugs2627323701216699155211250
(NSAIDs)2898323701212993142202226292332357
and32763237012148103160
ACE-I34573237012162117165196222
without3700323701217498131186241296329
clinical405132370121446890146169214262286
monitoring43583237012183138194217250304337361416472
of4851323701215584
kalemia4957323701214796119170253276324
(6.1530232370121297899144
%).54673237012179105123
Conclusion:3403373012460116176221250309353381439499524
Application8933377012161118175199222267316348371426482
of1396337701216292
Czech15163377012158103153198253
national17913377012162110143166221277325348
consensus21603377012152106162201251307346401440
(CNC)2621337701213691156215244
led2886337701213182139
to3046337701214094
documentation31693377012156111157212295346401434482515538593649
of3839337701216291
the3952337701214095145
highest4119337701216285141197247287320
prevalence4468337701215790139187236259309365410459
of4948337701216292
drug-disease5061337701216396151207240299322361411460499549
interactions340351701212379111160193242286322345400455494
in856351701212378
the955351701213388138
Czech11143517012158103153199254
sample1389351701213988171228252302
of1712351701215584
seniors1817351701213990146169224257297
in2135351701212378
long-term2235351701212378134190221255304337421
care2677351701214493125175
in2874351701212378
comparison2972351701214599183239288321344383438494
to3487351701213387
foreign3595351701212984117167190246302
explicit3917351701215098155179202247270303
criteria.4241351701214477100133183216239287308
With45703517012185109142197
the4788351701213388138
help49473517012156106130187
explicit5155351701215097154178201246269302
cri‑5478351701214577101132
teria340365701213382115139187
we5493657012174123
identified693365701212581132187220243272298349406
in1120365701212480
Czech12223657012158103153198253
long-term1497365701212479135191223256306339422
care1942365701214493126175
facilities2139365701213079124147170193226249299339
more25003657012183139171221
than2742365701213590138193
6029573657012152104
%30833657012179
of3184365701215585
seniors3290365701214091147170225258298
potentially36103657012157113146195251283306354378401448
prioritized4080365701215790114169202225258281324374432
for4533365701213085118
complex4673365701214599182239263314361
interventions5055365701212480112161194245294350382405460516555
of340379701215584
clinical44537970121497295150173218266290
pharmacists.7603797012157113161193277325370393432466506528
In1309379701212783
the1413379701213792142
light1576379701212850106162194
of1795379701215584
newly19043797012155106179203250
approved21753797012152109166199253301350407
payments26073797012157105151235286341374414
in3043379701212782
ambulatory31463797012152135192247270318351405438488
care3655379701214997130180
for3856379701213388121
interventions3998379701212782114164197248297353385408463519558
of4580379701215584
clinical468637970121487194149172217266289
pharmacists50003797012157113161194277325370393432466507
in5528379701212782
the340393701213388138
Czech4963937012158102152197252
Republic,7663937012153103160215272296318363384
services1168393701213989122173197241290329
of1515393701215483
these1619393701213085135174224
specialists1861393701214096147192215262286308347381421
should2300393701214095149204228284
be26023937012156107
utilized2727393701215587110133156199248305
for3053393701212681114
complex3184393701214599182238262312359
drug3561393701215688143199
revisions3781393701213079126150189212266322361
of4159393701215584
geriatric42613937012155106138162209241274297342
patients46203937012157106138161211266298338
in4979393701212175
primary5072393701215790113196243276326
care,5416393701214493125174194
particularly3404077012157106138174197242297320368400424472
in833407701212378
long-term933407701212378134190222255305337421
care,1375407701214594126176196
home15924077012156111195245
care,1858407701214594126176196
social2075407701214095141164211235
care2331407701214594126176
and25284077012148104160
palliative27094077012157106129153176223256279327376
hospices.31074077012155110149206229274323363384
Key3404243012461112164
words:5204243012476133171231275301
clinical83942470121456890145168213261284
pharmacy,11414247012157112160192275323368417433
geriatrics,15924247012155105138161209241273297341382403
drug‑disease2012424701215789144200231290313352402449488538
interactions,2572424701212074106155188236281316339393449488508
explicit3098424701215097154178201245268301
criteria,3416424701214577100133182215238286307
primary3740424701215790113196244276326
care,4084424701214493125174194
ambulatory42964247012148131187242265313345399431482
payments47954247012157105151234285340372412
of5225424701215584
clinical532642470121456891146169213261285
pharmacists,3404387012157113161193277325370393432466507528
Czech8894387012158103153198253
Republic.11634387012154105162217274298321366387
Úvod3404930014780142208279
V4805103010746
důsledku5465103010756104137157202253292341
stárnutí907510301074070112140189238267286
populace12145103010756106157206226267309352
a15875103010747
vysokého1654510301074791126176215259308357
stupně340524301073566117170222269
polymorbidity,6315243010761114136179257309338392413466487517563576
polyfarmakoterapie,12295243010762114136179209254283361405446496526571600645698719766783
geriatrické340538301075098127148192222251273316357403
křehkosti765538301075182128180220271307339360
a11485383010754
častých1224538301075397134165211254305
polékových15515383010763116138185226277320367409461
komplikací340552301073886161211231250289332373392
ve750552301074185
stáří855552301073261103130150
jsou102655230107175099148
klinicko‑farmaceutické119255230107386079127146187226274304329372399474515557600648677696737776820
služby340566301073453101139190230
podstatné5915663010757107158192222264292341386
zejména998566301074387107181226275317
u13365663010755
polymorbidních14115663010757107128168244293321372392442491511552601
seniorů340580301073479128148197225274
s6355803010741
polyfarmakoterapií6975803010757108128169198241268344386425473501545573615666686706
(1).142358030107327391105
K15495803010753
„rizikovým162258030107346383121141180228270314390
populacím“,3405943010750100151200219261302322396422433
u7925943010748
nichž858594301074868109158195
by1072594301074990
měly11805943010774119139179
být1378594301075090122
individualizo‑1520594301071766116136177198248296337357377414462492
vány340608301074082130169
lékové52960830107166098146186229
režimy778608301072467105124197236
klinickými103260830107375877125144184222265339358
farmaceuty,141060830107216390164205246288336365407419
patří1847608301074991118145164
i3406223010719
paliativní376622301074991111129170197216258307326
nemocní,719622301074892166214256304323339
nemocní1075622301074892166214256304323
v14156223010741
intenzivní147662230107166491134182219239280329348
péči,1842622301074994135154169
pediatričtí340636301075096147166207236263283325356375
pacienti,7366363010757100141161206255282302318
nemocní10756363010756101175225267316336
užívající1431636301075693113155198218237278298
vysoce1749636301074893128177219262
riziková34065030107274784104143191232275
léčiva,635650301072570112131173215232
léčiva888650301072469111130172215
s11236503010739
nízkým1183650301075372110149193269
terapeutickým1472650301073377104147197243292321340382420464540
indexem340664301071968118163204247322
apod.682664301074293143194211
Komplexnost480678301074593168217237282322371419453483
klinicko‑farmaceutických98367830107446584132151191230277307332374401476517558600649677696737775818858907
in‑1909678301072674103
tervencí34069230107287197142185234275293
u6536923010755
geriatrických7286923010756100127146187214241261301339382422471
nemocných1219692301075599173222264312351391439
vyžaduje1678692301074891130173222270289333
ke340706301073881
správným441706301073786113154194243282356
rozhodnutím817706301073077112161209259308355383402475
podrobnou1315706301075099149176223273322370418
znalost1753706301073988129148196230259
geriatrických340720301074993119139179206233252292330373413461
indikačních821720301072371120139176219259307326366414
schémat,1254720301073879127171245285312329
klinické160272030107436382130148188226269
far‑189172030107287096121
makologie3407343010773114151198217265314333376
v7327343010741
geriatrii,789734301074892118137177204230249267282
klinické108773430107385876124142182219262
farmacie136873430107206288162202242260304
v16887343010740
geriatrii1745734301074892118137177203230249267
a3407483010741
specifických401748301073382127168187211231271309352391439
aspektů860748301074174123168206237285
týkajících1165748301072870109151170189229247287335
se1520748301073478
rizik161874830107264582101139
farma‑177774830107236592166207235
koterapie340762301073884111153179220268287330
ve686762301074183
stáří,785762301073362102128147162
tedy966762301072466115155
schopnost1137762301073373121168218265313346374
aplikovat1527762301074190109127164210250291317
zna‑1860762301073684124152
losti340776301071968102131151
o5117763010755
polékových5867763010756106126171209257298342382430
geriatrických10367763010756101128147188216243262303342385425474
syndromech,1530776301074082132181208256331376417466482
symptomech2139496301073374148198225271345389430478
a26334963010741
změnách26904963010737110154202242283330
terapeutické304049630107256793134184228276304322362400443
hodnoty3499496301074896146194242269312
léků2139510301071962100148
ve2303510301074083
stáří2403510301073362102128147
v25665103010741
propojení2623510301074976123172221240283331349
se2988510301073477
znalostmi3082510301073684124143191224252326344
změn34425103010736110153201
pro‑3659510301075076123152
vázejících2139524301074182119162181200240258298346
stárnutí2505524301073463104130179227255274
organismu2798524301074875123164212231263337384
(1,320252430107246474
2).329652430107446679
Zatímco2279538301074991119139213255302
v26025383010742
současné2664538301073584134175217251300345
době3031538301074998149195
se3246538301073580
staly3347538301073564107127168
v35355383010742
České3599538301075195129168212
republice2139552301072669119168217237256297339
již249955230107163572
dostupné2589552301074897131160208258307351
služby296055230107315098135185225
klinických320255230107385978126145185224267307355
farma‑357755230107216390164205234
ceutů2139566301074082129157205
v23615663010740
akutní2419566301074078126154202221
péči,2657566301074994135153169
stále2846566301073059101120164
nepokrytým3027566301074791141190228256299330373447
segmen‑3493566301073175125198242290318
tem2139580301072872147
zůstává2307580301074494128158201242285
primární2613580301075886107182224252302322
péče,29565803010757104146190205
zejména3182580301074589109184230279321
domácí35245803010757107183225267287
péče,2139594301075199142187204
ambulantní23655943010750127179230251294345374426446
péče,28335943010759107150195212
paliativní30665943010759104125145188217238282334354
(hospico‑3442594301073384135171223245287337369
vá)2139608301074184109
péče22696083010757104147190
a24806083010749
dlouhodobá2550608301075878128177227277329379431474
ošetřovatelská3045608301075691136166194242284327356400420454494537
péče.36046083010757104147190207
Především2139622301074673118170216259294314390
v25516223010749
domácí,26216223010758108185227270290307
sociální2949622301074293136156198219269289
a32596223010750
dlouhodobé3330622301075778128178229279331382434481
ošetřovatelské2139636301074984130159187236278322351395416450489534
péči26956363010758105148168
je2884636301072773
nejčastěji29786363010757103123165208243274318338358
popisováno33586363010758109161182216266309352402452
vysoké2139650301074185120169208252
zastoupení2412650301073679113143190239290336385404
seniorů2837650301073378127146195223272
s31306503010733
častými3182650301074183117147190266285
geriatric‑3487650301074994122142183211239259300324
kými2139664301073983160180
syndromy,2340664301074284135186214263339380392
polymorbiditou,27546643010758108130171248298327379399450470500548598615
polyfarma‑33906643010758109130172200244272348391421
koterapií2139678301073887115159186229279300319
a24796783010748
očekávaným2548678301075698141181224265307357396472
výskytem3041678301074892127166210242286361
nevhodné34236783010755101143193242293343388
lékové2139692301071965105154196241
preskripce.2402692301075886131167206236256308351395411
Tuto2834692301075194124173
skutečnost3028692301074281131161205248298349384415
dokládají34646923010757107148170212263306326346
i21397063010719
dva2178706301075799141
mezinárodní23477063010773119157177226267295343394442462
evropské2829706301075193121169220254293337
projekty3187706301075684132152197236268311
ADHOC35197063010760119177238292
(AgeD2139720301072476125170229
in2388720301071765
HOme24727203010756117192237
Care,2727720301075193120164179
5.2924720301074459
rámcový3004720301072466140181229270313
program3336720301074977124175202244318
(RP)3674720301072268114137
Evropské2139734301074386116166219255295341
komise,2502734301074898176197232279296
2001–2005)2820734301075399148191235277323372418443
(3)3284734301073479102
a34087343010751
SHELTER34817343010751110155197236282330
(Services2139748301072467113142188209252296332
and24937483010749100152
Health26667483010766113155176206256
in2944748301072777
the3043748301073687133
Elderly3198748301075071122169197219261
in3480748301072778
Long­3579748301074999150202232
‑Term2139762301072765105132207
Care,2370762301075294121165180
7.RP2571762301074755103149
Evropské2741762301074586114162213248286330
komise,3092762301074189164184217262278
2009–2016)3390762301074892138184232272316357397421
(4).213977630107246688102
Projekt2260776301074571119139184222254
ADHOC25327763010753112169231284
poukázal28347763010750100149187231269312331
u31847763010747
seniorů3252776301073176125144193221270
v35407763010741
České3599776301075195129167211
republice3938496301072772124174225247267309353
na43124963010757100
vysoký4433496301074994130181221266
výskyt4720496301074994130170215248
nadměrné4989496301075799151227273301352398
poly‑54084963010758110131173202
farmakoterapie393851030107246794169211250298326370397439490510555
(94513510301073172
a46065103010747
více4674510301074767108152
léků)4846510301072671110159181
u50485103010754
395123510301075093
%52435103010766
seniorů5330510301074085134154203230280
v39385243010740
domácí3995524301074895168208248267
péči4279524301074893133151
a44475243010740
na4504524301074787
potenciálně4608524301074997124166214254272312331378421
problematickou5046524301074975122171191234307347374392432469516564
lékovou3938538301071964102150191239288
preskripci4244538301075077121155194222242292334354
u46165383010747
414682538301074382
%47825383010766
seniorů4869538301073176125144193220269
(3,515953830107216480
5).525753830107446781
Projekt5356538301074572119139184222254
SHELTER39385523010743102148191231278326
zdokumentoval42875523010755107159201253331379431461511555600622
v49325523010759
dlouhodobých5014552301076890142194246298352404458501544596
ošetřovatelských3938566301074882127156183231272315343386406440478522563612
zařízeních4570566301073578106126163207256275316365
užití4955566301074885105134154
105128566301074485
a52325663010741
více5293566301074061102145
léků5459566301071862102151
u39385803010748
23,74006580301075196111155
%41895803010766
seniorů4276580301074085134153202230279
v45765803010747
evropských4644580301075092120168219253292336376425
zemích5090580301074286161180221270
a53815803010747
užití5449580301075492112141161
lékových3938594301071963102149190233273321
postupů4277594301075099133162211260309
potenciálně4603594301075099127170218259278319338386430
nevhodných5051594301074893133183231282330369409457
ve5526594301074084
stáří3938608301073463106133153
u41126083010748
40–79,64182608301074490139180223236282
%44856083010767
nemocných4573608301074894168217260309348389438
(4,503160830107256783
6).513560830107446882
Cílem407862230107516990133206
studie4301622301073362109158177220
bylo4538622301074988108155
retrospektivně471362230107236693120166200248293331361380421469513
zhodnotit,5242622301073685133182230278305324351367
a39386363010742
to4000636301073583
s41046363010741
využitím4165636301074993143181201230250325
dat4511636301075698126
českého4658636301074891126165209259309
souboru4987636301074191140191242270320
seniorů5327636301074187136155205233282
projektu3938650301075077124144188226257306
SHELTER,42646503010748104146186223266311329
jaké4613650301072666105148
procento4781650301075684131172215264291338
geriatrických51396503010755100126146187214241260301339382422471
nemocných3938664301074994169218260309348389437
lze4396664301072663107
v45236643010748
oblasti45916643010755106126168202231251
interakcí4862664301072674102145172214253293312
lék–nemoc5195664301072670109153203248323373415
v39386783010741
zařízeních3999678301074486113133170213262281322371
dlouhodobé4390678301075675124173222271322371421467
ošetřovatelské4877678301075589134162189237278320348391410444482525
péče54236783010756102144187
v39386923010741
ČR40006923010759105
prioritizovat4125692301075785105154182201230250287335377419447
ke4592692301074690
klinicko‑farmaceutickým470269230107466786135154195234283312338381408484525567610659688708749788831908
intervencím.393870630107196795138164209253301342361435452
K44107063010752
tomuto4482706301073482156204233280
hodnocení47827063010755104155204253294337386405
byla5207706301075696116157
využi‑5384706301074892141178198226
ta3938720301072871
explicitní4029720301075292144164183225244273323342
kritéria439172030107467595124168195215256
léčiv4668720301072671113133175
a48637203010749
lékových4932720301072772111159201245286335
postupů52887203010757108142172221272322
potenciálně39387343010751103133178229272292335356407453
nevhodných44137343010766113156208259312363404446497
ve49327343010758104
stáří,5057734301075182126155176193
zejména5272734301075399119196243294338
jejich393874830107206484103144193
části4152748301074790124154173
věnované4345748301074993142191232275324369
geriatrickým47357483010756101129149190218245265306345389465
interakcím5220748301072675103146174216255296315390
lék–nemoc,3938762301071963101145194238312360401417
které4375762301074273115142185
nejsou4583762301074893111144193241
předepisujícími4847762301075077119169214263282315362381400440458532550
lékaři5417762301072367105147173193
v39387763010741
současné3998776301073482131171212246293337
době4355776301074997148192
dostatečně4567776301074997131160201228271312360404
respektovány.4991776301072669103152197235266313353394442481493