921
KLINICKÁ341804301074588109168189242288347
FARMAKOLOGIE708804301074392139212266313373416475534555599
A13288043010753
FARMACIE1402804301074292139211266317337381
/18048043010757
Klin1880804301077091109157
Farmakol2057804301074278105179220258305325
Farm2402804301074178104179
2019;2601804301074386126164180
33(3):2801804301074385107150171185
11–163006804301074478120159198
/32238043010757
www.klinickafarmakologie.cz4568804301076513320121425327329234035839843647950254457164568672477179183988990895196610061045
161878026012657111
ORIGINÁLNÍ341207012673138172244278352422476549582
PRÁCE945207012660124196256314
Targeting34136501063066101141173206224265304
asthma66136501063872104146200240
control91736501063271113145181222253
in118536501061657
real‑life125836501063365107138160191208239271
clinical15453650106326381122140174216247
practice180836501063268109143176194229261
by208436501063470
using21703650106397188129168
ICS/LABA23533650106165185111142184219259
combination262836501063271125161179220260288306346388
latively3436230107195884102142184202241
high59862301074866113160
proportion77362301074975121169217243273290337385
of117262301074871
enrolled125762301074390115161180197240289
patients156062301075090116134176223249282
with185762301076483109156
chronic34376301074087112158206223262
bronchitis62076301074975121169208255272299317349
or98476301074773
COPD1072763010751107152208
as129476301074173
comorbid138276301074086158206232281299347
conditions17437630107418613318219922624434390301074895127
(29%).48990301071961103169189201
However,705903010757104167210249291316327
the105190301072370113
two118390301072490136
diagnoses133490301074966105153200247280323355
were1704903010765107132174
not189390301074895121
confirmed343104301074086134156175200274317366
by730104301075088
performing839104301074993119145191218291309356404
bronchial1264104301074975122169209256274313331
reversibility1614104301072870110152178211229277295313331358400
testing343118301072869102130148195244
with605118301076583110157
respect781118301072668101149193233263
to1063118301072772
a11531183010741
real‑life1213118301072668107125152171189212255
design1485118301074993125143191238
close1741118301074058105138181
to1941118301072773
everyday343132301074382124149191238277314
clinical67213230107405774121138177217234
practice921132301074974115154183200239280
and1215132301074187135
possible1364132301075097129161178226244287
additional1665132301074189137154181198245292331349
workload3431463010765112138175195242283332
for69314630107247096
participating808146301074990116146164203221269310336354401449
physicians.1276146301074997135168185225242282329361377
Generally,16711463010756100148191216257275293332343
the343160301072875118
proportion480160301075076122171219245275293340388
of887160301074771
patients976160301075090117135177225251285
with1279160301076583110158
features1456160301072365105131178203245278
of1753160301074871
both1842160301075098124172
asthma343174301074173101149221261
and623174301074491140
chronic782174301074390115162209227266
bronchitis/COPD1070174301075076122170210257274301319351383431488533589
is1678174301072253
unclear1753174301074895135153196235261
and343188301074189139
woud5071883010766114162211
have737188301075596135178
been941188301075095139188
influenced114818830107257396118165209257298340390
by1563188301075190
the1672188301073482127
initial181818830107257391119137177196
inclusion343202301071966105123169201218265313
criteria67020230107406684111152178196235
used920202301074880123172
for111020230107206692
the1221202301072471114
studies1350202301073361108156174217249
fromwhich161820230107194692165244292309349396
the343216301072875118
data475216301074989115155
were6452163010764107132174
drawn.833216301074974115178226241
In1092216301071562
epidemiological1169216301074392110158201273290337356403452469508549566
studies,1750216301073461108156174217249264
the343230301072875118
reported480230301072668116165191221263312
prevalence809230301075076118158199217260307347388
rates121623030107256692134167
for140223030107226995
asthma‑COPD1515230301074073101148221261288341398443499
overlap343244301074786127152170208256
have613244301074786124165
ranged796244301072262108155198246
between1056244301074992118183224267313
15%1383244301074479141
and1538244301074187134
55%,1686244301074382144159
with1859244301076482108155
variation214162301074081106124163189207253301
by245662301075088
gender255862301074992139187230255
and282862301074087135
age,297862301074088131145
and313762301074187136
the329162301072471114
wide341962301076583131174
range361162301072363110158201
reflects21417630107266891112155195224257
the241776301072471114
different25457630107496689115158183225272297
criteria28577630107406583110151177195234
that310976301072471110136
have326076301074887126168
been344276301075093137184
used364076301074880123171
(2).21419030107246790102
Another2269903010754102151179227272298
cross‑sectional258790301074773121155188214248293334365383432481522541
observational3147903010755106139184210255296324342391440481500
study3666903010740691182141104301074988
using225210430107488097144193
a24631043010745
stepwise2527104301073766107156220238270313
approach2859104301074593142169215255295342
according3220104301074584122168194241259306355
to3593104301073278
the3690104301073179122
GINA/GOLD2141118301075776133185220274335376434
guidelines25951183010755103121170214233251299343377
identified2991118301072574118166193211235254298348
only33581183010755103122162
9.2%3539118301075163109175
of3734118301075478
COPD21411323010751108153209
patients2370132301075091117135178225251285
as2675132301074173
having2769132301074888127145192241
asthma‑COPD3030132301074173101149221261288342398443499
overlap3550132301074887129155173213262
(21).2141146301072466104121133
It2293146301072148
is2360146301072153
well24341463010765108126144
known2597146301074089136200248
that2864146301073077117143
asthma/COPD3026146301074376104151224264296345401446502
overlap3549146301074888130155174214262
syndrome2141160301073372118165190235306348
is2507160301071444
associatedwith2565160301074071102148187204242267308355432450476522
amore31001603010740126172197238
severe3351160301073375113154179220
course3584160301073984129154186228
of2141174301074871
the2231174301073482125
disease,2375174301075573105148188221264278
lower2672174301072572136179205
related289617430107327593133160201251
quality31661743010755102142160177205247
of3432174301075377
life,352817430107254265108122
and3669174301074794143
more21411883010774121147189
frequent234918830107235092141187231278304
exacerbations2671188301074382123162204229279319346363411458490
(22).3180188301072365108129142
Our22812023010762113141
study2443202301074273123174216
had26802023010758101152
several2853202301074389131176204248268
limitations.3142202301072847123143173216245265315366400418
These35812023010751103149184231
included2141216301071969111131180231277329
the2490216301073686132
real‑life2643216301073478120140169190210235280
design29432163010758103138158209258
and3222216301074999150
absence33932163010749100135181231273317
of3730216301075782
a21412303010742
control2204230301075199150179207256277
group.2502230301076088137188239256
In2779230301072979
addition,28792303010751103155175204225275326342
a32422303010752
three‑month3315230301073888116161208239316367418446497
follow‑up214124430107247191110158223251300350
does25112443010756104149183
not27142443010755103131
provide2865244301075683130171190239284
a31692443010747
sufficient3236244301074087111139159199218262310337
possibility3593244301075610613917319139396230107506988106134177
to413562301072572
monitor4224623010774122171189217264291
the453562301072573117
maintenance4669623010774115133181208250299339387428470
of515662301074872
long‑term524862301071664113162190218261287362
asthma393976301074173102149222262
control421776301074086134160187233252
and448576301074188137
its46417630107164378
impact473876301071588137178218247
on500276301074795
the511676301072572116
frequency52517630107204790139186229277317359
of393990301074872
flare‑ups40319030107234686113156185234283317
and436790301074189139
other452590301074876124168195
serious473990301073478104124172220253
events501290301074384127175202237
as526990301074174
well.5363903010765108127146162
Conclusion39391150014771137206261292361411442510580
In4079132301072071
a41711323010751
majority42531323010776119141192221242273318
of4593132301075885
uncontrolled46991323010758109153202254283312362384405452505
asthmatic5226132301075187118169246290320340384
patients,3939146301075093122142187237266302319
significant4279146301074261112162182207228270313363391
improvement46911463010726102153181230272317392438488516
of5228146301075681
disease5330146301075878112157199234280
control3939160301074088137165193241261
represents4221160301073377127155199233278328355391
an4633160301074796
achievable4750160301074788137157201243285336356401
goal51721603010755105147167
thanks5360160301073483125174212250
to3939174301072877
an40381743010749100
appropriate41591743010749101154182232284313334376405450
pharmacological46311743010758109152180257300343392413464516536579622643
strategy5295174301074373102146175220272315
coupled3939188301074088137187208253304
with4264188301076585114163
interventions444818830107206996140167212256305333353402451485
aimed4954188301074161135180231
at5206188301074270
a52961883010742
proper5360188301075078126177222250
inhaler3939202301071968117158178223250
technique4210202301073074116165214233283331376
and4607202301074392143
adherence.4770202301074494143188215259308350393409
Along5202202301075373122171221
with5447202301076585114163
treatment3939216301072856100141169244290339367
of4327216301075580
the4428216301073685130
underlying45792163010756105155201228249290310359410
disease,5010216301075676110155196231276292
it5323216301072655
is5399216301072660
important548021630107261013939230301074998125156198246273
to4232230301072572
pay4321230301074991130
close4468230301074059107141185
attention467123030107406798141189216235283332
to5023230301072571
comorbidities5112230301073986160208235285305354373401420464498
and3939244301074190140
smoking41002443010734108158197218267317
cessation.4438244301074184119153196224244293342359
REFERENCES3442680012357112167220281336407470524579
1.34328400853648
Hrubiško41128410834465104143158184214252
M,68328410835468
Čižnár,7662841083456089128160181191
P972284108340
et102828410833861
al.11042841083375265
Asthma11892841083416992130188220
bronchiale.142528410834365102141173211226258273308320
Národné17652841083457799136175213248
smernice34329410832684119140179194226259
pre6182941083386094
terapiu.7272941083225677110149165202215
BONUS,95829410833583128173204217
Bratislava11912941083355689111126152168200231264
2010.147129410833468100131144
2.34330400853652
Global4093041083446098137170186
initiative610304108314526790105137159174206241
for8663041083185577
asthma:9583041083325881120177210222
GINA119530410834359104145
Report,135530410833570110148170195208
Global15783041083435997137170185
Strategy17783041083335475108130164203235
for3433141083185678
Asthma4353141083416992130188220
Management67031410835487125157196231289324362383
and106831410833270109
Prevention,11913141083355690122156194216231269308320
2017.152631410833468100129135
Available167631410834171104119134167206222257
at:19473141083325367
file:///C:/Users/monik/Downloads/wms‑GINA‑main‑pocket‑guide_2018-v1.3433241083173448839512114216220021324028430934436539241747351154956359362166770575679480984787991894496910201077110311241170118512301271129213501382139714341456149615341566159616301651121141155156190218249282313343373394426457466
0.82332410833446
pdf8843241083397896
(Date9963241083186395117150
accessed:11613241083326495128155181216255267
17.14443241083346369
05.15283241083346880
2019).16243241083346899130147158
3.34334400853752
Bateman4103441083417496130189222260
ED,6853441083388495
Boushey79634410834079118145183218250
HA,106634410834587101
Bousquet118234410834180119145185223258281
J,147834410833042
Busse153534410834179106132168
WW,1723344108359120130
Clark18733441083415689110141
TJ,3433541083335364
Pauwels42535410833566103153187202227
RA,6703541083357791
Pedersen77835410833568107141161188222260
SE.10523541083366780
GOAL114935410834491130161
Investigators13243541083185586119146168183221252273310330357
Group:169835410834465101139177189
Can190435410834072110
guideline‑defined3433641083387589128162177191228262285325359376393430464503
asthma8613641083315780117174206
control108236410833167105126146183198
be129536410833973
achieved?138336410833263101115149181214253279
The167636410833372106
Gaining17973641083437590127141178217
Optimal34337410834787109124182214229
Asthma5913741083426992130188220
ControL83137410834077116137158195227
study.10733741083315492131163172
Am126537410834199
J1379374108329
Respir142337410834075102141156177
Crit1619374108340617698
Care17373741083407394128
Med188437410835590130
2004;34338410833468103139150
170:5073841083346295107
836–844.62838410833468101138174210246258
4.34339400853650
Allegra4053941083415670104143164196
L,61439410833144
Cremonesi6703941083406094151188226261287301
G,98439410834356
Girbino10523941083435879118133170208
G,127239410834457
et134139410833455
al.14093941083314659
(PRospectIve14823941083165186123149188223255278293325359
Study18533941083325390128160
on34340410833775
asthMA4314041083325881119174216
control)66040410833168106127149186201221
Study8934041083335492130162
Group,106840410834365102140179191
Real‑life127140410833670102117140156171190224
prospective15084041083386097123162197230254269301336
study18564041083264987126158
on34341410833776
asthma4334141083325882120178210
control65741410833168107128150187203
in87541410831452
Italy:942414108314366984116130
cross‑sectional10864141083315290116143164191226259283298336375407422
phase152341410833877109136171
results.17094141083205481118133156183197
Respir1920414108336713434241083266581102
Med46042410835490129
2012;60442410833569100130143
106:76242410833466101114
205–214.89142410833468103139170202233245
5.34343400853649
Demoly40743410834579135172186216
P,63943410833538
Paggiaro69343410833565102140153183203238
P,94743410833638
Plaza10014341083364979107139
V,115643410833542
Bolge12144341083367287124157
SC,13874341083337183
Kannan148643410833566103139169206
H,170843410834455
Sohier177943410833369106119152172
B,196743410833546
AdamekL.Prevalenceofasthmacontrolamongadults343444108341771071621952232632743183373683984294424755115415726186356757007217578128428829169539729911026104010801136117212081245128513221357137013901416
inFrance,17724441083104687105135171201232242
Germany,3434541083437695151181216244252
Italy,SpainandtheUK.EurRespirRev2009;18:105–112.608454108310306174103111152188219232267307343379409445478530563576617651669713746770807820839883915945987101910531085109611391167117712201249128113141343136813961406
6.34346400853551
Eucan40646410833268100132169
Aim58746410834156112
Executive7124641083326497129166188203235269
Summary99346410833269126182214235268
2010.12734641083346899130142
http://www.takingaimatasthma.eu/1427464108337588212113315917922928133434436639842744348051955056534347410835790111144171194232290322336370408434
(Date7934741083186496118152
accessed:9604741083326495129155182217256269
17.12444741083346470
05.13294741083346880
2019).142547410833468100130148159
7.34348400853544
Braido3994841083355688103141178
F.58948410833238
Failure640484108332607590126147180
in83548410831249
asthma8974841083315779117174205
control:111548410833067104125146183198210
reasons13404841083175182108145183209
and156148410833169107
consequences.1680484108331671051311652032402753123434941083326693107
Scientifica4664941083387086121160182197215232265298
2013;78049410834074107137149
Article9444941083476994109142158193
ID115349410832066
549252,123549410834075109143178212224
15147549410834070
p.156149410834457
http://dx.doi.16344941083436590130142169190227258272312351367380
org/10.1155/2013/5492523435041083375997123156188200231259289321345380414446476500534569602635670703
(Date10625041083186496118152
accessed:12295041083326495128155182217256269
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05.15985041083346880
2019).169450410833468100130148159
8.34351400853550
Greening4055141083436496131168182219256
AP,6735141083407579
Ind7665141083124987
PW,86451410833591100
Northfield97651410834481102126162179196229244282
M,127051410835366
Shaw13485141083316899149
G.150851410834356
Added157651410834077115149187
salmeterol177551410832658721281621842163435241083205773
versus4285241083316586112149175
higher‑dose6155241083375290127162183202242279305340
corticosteroid9675241083316788113127159195221244277298335350388
in137052410831249
asthma14315241083325880118175207
patients16505241083387192107141178199227
with18895241083506587125
symptoms34353410832659118157179216274301
on65953410834381
existing7565341083397086112135151189228
inhaled9995341083205896128144179219
corticosteroid.12335341083367395120135167204231254288309347362401414
Allen16685341083415671106145
&1825534108339
Hanburys18765341083457711521412841083397798132159
Limited231528410833247105120142176216
UK254628410834479
Study26412841083325391130162
Group.281828410834466103141180193
Lancet302628410833165103135169191
1994;323228410833565100136148
344:339528410833470106119
219–224.35292841083346696133165200231244
9.214129400853649
Pauwels220529410833971108160194210236
RA,24562941083398296
Löfdahl25672941083357292130163201216
CG,28022941083408195
Postma291229410833976102125184216
DS,31472941083457890
et325329410833759
al.33282941083355063
Effect34072941083365574108141165
of358729410834160
inhaled3662294108319569412721413041083154988
formoterol22443041083165375133171192226247283299
and255630410833169108
budesonide267630410833977115150176214252267305340
on302930410833775
exacerbations31163041083346598129163184223256277292330368394
of352230410833756
asthma.35913041083325881119176208221
Formoterol21413141083326990148186208241262299314
and246831410833169107
corticosteroids25883141083316789113128160196222245278299336351390416
establishing30163141083346083116154170185210248262300338
therapy33703141083195691112144183214
(FACET)35993141083164885124156191213
International21413241083155273106127165197219234271309341356
study25093241083264986125156
group.26783241083375895133171183
N2874324108344
Engl293132410833269108123
J3069324108321
Med310232410835489128
1997;32423241083346499131141
337:33953241083346698108
1405–1411.351532410833465100134170200231260288297
10.21413340085367085
Nathan22413341083457799137169207
RA,24633341083367993
Sorkness25713341083337192123162197224251
CA,28373341083408397
Kosinski29493341083357299114152178208224
M,318833410835568
et327233410833456
al.33433341083324760
Development341833410834681113148163201241299334372394
of214134410833756
the22113441083195691
asthma23143441083315780117174206
control253234410833167104125146183198
test:27453441083195278100113
a2871344108331
survey29143441083266383117151181
for31103441083165374
assessing31963441083315783117144169184221259
asthma34673441083325880118174206
control.3685344108331671052141354108322438096109
J2265354108325
Allergy23053541083415671106128166198
Clin25183541083405570108
Immunol264135410831573131168206245261
2004;291735410833468104141152
113:30853541083346291103
59–65.320335410833467104141175187
11.21413640085356576
Pellegrino2230364108335678297131169190205242279
R,252136410833549
Viegl25823641083355184123138
G,273236410834356
Brusasco28003641083355693118151177208244
V,305636410833544
et311236410833355
al.31793641083314658
Interpretative32523641083124970103123162183216238270291306337371
strategies3635364108326486910112215521413741083385387114
for22703741083155374
lung23593741083125087126
function25003741083165492123147162200238
tests.27533741083195379102129143
Eur29083741083336990
Respir30103741083367097135151171
J3197374108321
2005;323137410833467103137147
26(5):33913741083346786119137149
948–968.355337410833469105141176211246259
12.21413840085366783
Bateman22373841083356889123180212250
ED,24993841083337889
Bousquet260038410833573111137176213248270
J,288538410832133
Busse29313841083357298125159
WW,3103384108357117127
Clark32433841083395486107137
TJ,33933841083325365
Gul34713841083438196
N,358038410834457
Gibbs36493841083445998137163
M,214139410835468
Pedersen222239410833568108142164191226264
S;249939410833244
GOAL255639410834391131162
Steering27313941083335487123144160197236
Committee298039410834077135193208230255288324
and331739410833169108
Investigators:34403941083135182116143166181220252274311332360372
Stability21414041083325385123138153167189222
of237540410833756
asthma24434041083315780117174206
control266140410833167104125146183198
with28714041083506587125
regular30104041083185190127142173194
treatment:32194041083183973104125182216254275288
an351940410833168
analysis360040410833168100115146172186212
of214141410833757
the22134141083226095
GOAL232341410834491131163
study.25014141083275088127159169
Allergy26854141083415672106128166198
2008;289841410833468105140152
63:30664141083346779
932–938.316041410833467100134169201236249
13.21414240085366882
Murray223642410835492113134167197
J,244842410832234
Rosenthal24954241083357399134172193231263278
R,278642410833549
Somerville284742410833371128163184219234249264299
L,315842410833145
et321642410833355
al.32844241083324760
Fluticasone33564241083334784106122153186212250288323
propionate3692424108338599621414341083395492131163185218
and237543410833674113
salmeterol25034341083306479137172194228249286302
administered282043410833675133148186201228251284306340379
via32154341083355183
Diskus33184341083456187117155181
compared351443410833673131170203224258298
with21414441083516689127
salmeterol22834441083276176134169191225246283299
or259944410833759
fluticasone2674444108317347294109141174201239277312
propionate30034441083396097137153191229261283317
alone33354441083334987125160
in351144410831553
patients35814441083397293109143181203231
suboptimally214145410832663102141181203218276308324339371
controlled252645410833168106128149186202217252292
with28324541083506688127
short‑acting297445410832562101122147167199231255270308347
β2-agonists.33354541083387292124163202240255281304332346
Ann369545410834179117
Allergy21414641083415672106128166198
Asthma23544641083416992130188220
Immunol259046410831572130168206244260
2004;286546410833569105141153
93:30334641083346778
351–359.31274641083346798131163196228239
14.21414740085367086
Schmidlt224347410833871109168183223239261
O,252547410834859
Petro26004741083417598120157
W,277847410835969
Hoheisel286847410834483122158173200236252
G,314147410834458
Kanniess321447410834175114152168203230258
F,348747410833844
Oepen355247410834884124160199
P,376747410834045
Langer‑Brauburger214148410833165103142177198218255276309347386424445483518539
B:269648410834052
Real‑life276348410834075107123145161176195230
effectiveness30084841083395877112144169184216251289324351377
of340048410834262
asthma34774841083366386124182214
treatment37074841083264882214149410833254112147185206
with23664941083506688127
a2508494108335
xed‑dose2558494108368102142164204243269304
uticasone/formoterol287849410837497112144177203242280315341360398420478516538572593631646
pressurised35434941083396094121148185206222248214150410833473
metered‑dose222750410835791113147168201240262303340367401
inhaler26435041083135088120135169190
eResults284650410833469104131167183205232
from30935041083163875132
a3238504108332
non‑interventional328250410833876114136152189210244265299333371392407445483515530
study.21415141083264987126158168
Respiratory23255141083357097136151172205227264286320
Medicine266051410835490129144176191229264
2017;293951410833569101130140
131:30945141083346495104
166–174.321351410833465101139170199229242
15.21415240085356781
Lundbäck223452410833167104142180212243272
B,251852410833547
Rönmark257752410833572109165197217247
E,283652410833244
Lindberg28925241083314683121159193214251
A,315552410834053
Jonsson32235241083215896121147184221
ACH,345652410834179122134
Larsson36025241083316384110136173210
LG,21415341083317387
James224353410832355113148175
M.243153410835569
Asthma25135341083416992131188221
control274753410833268107128150187203
over296453410833769103124
33102534108334
years31505341083316597118145
in331153410831351
a3375534108332
real‑life34225341083195385101123139154173208
study.36455341083254886125157167
Respir39392841083357097136152173
Med412728410835590129
2009;427228410833468104139152
103:44392841083346699110
348–355.456528410833469105142174207240252
16.39392940085367086
Braido40402941083416396111150189
F,424429410833844
Baiardini43032941083417489121143181196234250
I,456829410832033
Bordo461629410834181104144184
A,481729410834763
Menoni490329410835592132171212228
S,514829410833954
et521829410834165
al.53002941083385570
Coping538629410834786127144184224
with39393041083506791130
asthma:40843041083326084123182215229
is432930410831441
the43863041083216096
physician449730410833978110138154187204237276
able47883041083327289125
to493030410832058
identify50043041083145490129152168188224
patient’s52433041083397396112148187210226252
behaviour?551030410833975393931410833871104121161200223247
Respir420231410833773102142159182
Med440231410835491132
2012;455031410833671104136150
c106:47163141083336598135149
1625–1630.488231410833568103139177209242277313327
17.39393240085366979
Terzano40353241083356790122157196236
C,429032410834054
Cremonesi43633241083406298157197236273301317
G,469932410834459
Girbino47773241083436083124141180220
G,501532410834459
et509132410833660
al.51673241083345165
on524932410833979
behalf534732410833976115149166186
of555032410834060
the39393341083226198
PRISMA40533341083407794127183227
(PRospectIve42963341083246197137165205242276302318352388
Study47013341083375999139172
on489033410834282
asthMA49893341083366489128185228
control)523433410833674114137160198216236
Study54873341083376099393934410833871
Group:402734410834972111150191205
1-year42483441083406093129162185
prospective445034410834467105133174211245270287321357
real48233441083266295112
life4952344108320365793
monitoring506734410835797137153177215238255295335
of541934410834363
asthma54993441083376590393935410833898132
control408835410833877117140164203220
and432535410833979120
quality446235410834584118135152176212
of469135410834465
life4773354108322385996
in488635410832161
Italy.4964354108321458097130142
Respir512335410834279108149166189
Res532935410834279108
2012;545435410834177110142156
13:39393641083346578
112–123.40343641083366596132164195231245
18.39393740085366985
Al‑Jahdali40423741083415679100132170209242257272
H,433137410834457
Ahmed440537410834180137172212
A,463437410834155
Al‑Harbi47073741083415678124157178217233
A,495737410834155
et502837410833658
al.51013741083344962
Improper517937410831674113135172212247269
inhaler5463374108316549212539393841083155072
technique40263841083276295133172187226264300
is434138410832047
associated44033841083386491130163179211233267307
with47313841083516790128
poor487538410834484123145
asthma50353841083386488127185218
control526838410833775113135157195211
and549538410833775115
frequent39393941083184075114152187225246
emergency419839410833492127148186221259292325
department453639410833873112145166191249284322344
visits.4893394108331477388110138152
Allergy50583941083415671106127165198
Asthma52693941083416892130187220
Clin55023941083405570108
Immunol393940410831573130168206244260
2013;421540410833468100130141
9:437140410833448
8–18.443440410833471102133146
19.39394140085366982
Al‑Zahrani40354141083415679115148186207240278293
JM,43434141083227791
Ahmad444741410834179137169208
A,466941410834155
Al‑Harbi47374141083415779125157178218233
A,498441410834155
et505241410833456
al.51224141083314760
Factor51954141083326294118155177
associated5385414108332588512315617120339394241083215594
with40454241083506688125
poor418342410833876115136
asthma43314241083325881118175207
control455142410833167105126147184200
in476642410831249
the48304241083195691
outpatient49334241083377597136169190205239277298
clinic5243424108331466198113144
setting.54004241083266082106121158197210
Ann393943410834179117
Thorac407143410833372111132165197
Med428443410835489129
2015;442843410833468100130141
10:45844341083346679
100–104.467843410833466102140171202239251
20.39394440085377795
Yildiz40534441083456583126144177
F4248444108343
and431044410834183126
On4455444108357100
behalf457444410834988130166185207
of480044410834770
the488944410833173112
ASIT501944410835290107145
Study518344410834267109152187
Group:538944410835479120162205221
Factors39394541083326498124163187216
influencing4173454108318587999139176216250267307348
asthma45394541083356489129189224
control:478045410833574114138161201219233
results50304541083246190129146171201
of524845410834162
a5328454108335
real‑life53804541083246094112136155172193230
prospective393946410834065106136179218254282300336374
observational433246410834689120158183221258283301343385421440
asthma47904641083417197139202237
inhaler504646410832365107142161199224
treatment52884641083315593129154216255297322
(ASIT)39394741083196298115151175
study.41314741083285494135169181
J4329474108327
Asthma43754741083417196137197231
Allergy46264741083415875112136176210
2013;485347410833773107139152
6:502347410833651
93–101.509147410833671110143176210221
21.39394840085367185
Inoue40404841083145494133169
H,422548410834559
Nagase430048410834578119152180217
T,453348410833243
Morita459248410835494117134158192
S,480048410833347
et486348410833458
al.49374841083324863
Prevalence50164841083355792126160177213253286322
and535448410833171111
characteristics54824841083317010439394941083215588114149171188216240257290319
of427449410833757
asthma‑COPD43474941083326084124183216240284331368414
overlap477749410833771106129146179220
syndrome50134941083255999140162201260297
identified53264941083145490129152169190207243284
by393950410833971
a4027504108333
stepwise40775041083275287128180197225261
approach.435550410833374115138176211244284298
In467050410831655
J4742504108326
COPD478650410834087124170
2017;497350410833671104135146
12:51365041083366781
1803–1810.523450410833568104139176209241275307321
22.39395140085367491
Hardin404951410834478100140156196
M,426351410835570
Silverman43495141083345067101137159219253292
EK,46585141083347187
Barr47615141083377294118
RG,48955141083378398
et501051410833559
al.50865141083335064
COPD516951410834086124170
Gene535851410834380120156
Investigators:55315141083165639395241083326796120137177211234272295324338
The429352410833677113
clinical44235241083355268107124157191208
features46485241083225791114153176211240
of490452410834162
the498252410832565101
overlap510052410834174110132150183224
between534152410834279102157193229269
COPD393953410834087124171
and412653410833473113
asthma.42565341083336186125185218233
Respir450653410833773101142158181
2011;470453410833571104133143
12:48635341083366781
127–135.496153410833567101135167199233246