1033
www.klinickafarmakologie.cz340804301076513320121425327329234035839843647950254457164568672477179183988990895196610061045
/26478043010757
Klin2723804301077091109157
Farmakol2900804301074279105179220258305325
Farm3245804301074178105179
2019;3444804301074487126164180
33(3):3644804301074485107150171185
11–163849804301074479120159198
/40668043010757
KLINICKÁ41438043010771114135194215269315373
FARMAKOLOGIE4536804301074392139212267313373416476535556599
A51578043010752
FARMACIE5230804301074292139211266317338381
1556558026012657110
ORIGINÁLNÍ4694207012673138172244278352422476549582
PRÁCE5298207012660124196256314
Targeting293736501063066101141173206224265304
asthma325736501063872104146200240
control351336501063271113145181222253
in378136501061657
real‑life385436501063365107138160191208239271
clinical41413650106326381122140174216247
practice440436501063268109143176194229261
by468036501063470
using47663650106397188129168
ICS/LABA49493650106165185111142184219259
combination522436501063271125161179220260288306346388
period,340258301075095121140188238254
we6152583010765108
found743258301072573121169218
a9812583010742
decrease1044258301074993135161204244278322
in1385258301072168
the1473258301072978122
proportion1616258301074976124174223250281299348396
of340272301074872
patients431272301074991118137181229256291
reporting741272301072669119168195226245292342
day‑time1102272301074989128156184202276320
symptoms1442272301073374148198225272346379
from184127230107235097171
93%340286301074485150
to510286301072673
23%,601286301074488153169
night‑time789286301074866115163190215243261335379
symptoms1188286301073273147197224271345378
from158628630107225097171
81%1775286301074484145
to1940286301072672
10%,340300301074483151167
limitation527300301072139112131159200227246294343
in890300301072068
common977300301074288163236285333
activities1330300301074283113132173192220239283317
from1666300301072553100174
67%1861300301074485151
to340314301072876
5%,4363143010751116134
and590314301074897147
use757314301075589134
of911314301075680
rescue1011314301073478112154202247
medication12853143010775120171190231273301320369418
≥17303143010755
twice18053143010735104123164208
a3403283010741
week4013283010765109153192
from61232830107245299173
62%806328301074486152
to977328301072976
8%.10733283010744110128
In1220328301072068
line130832830107193886130
with1458328301076584112161
clinical163832830107416078126145185227245
success,1903328301073481340342301074180124158192209
we5763423010766110
observed7073423010755106140186213258302353
improved10803423010726101151179227268312364
lung1464342301072674123174
functions1658342301073181130171202222271320354
(an340356301072462110
increase470356301072270111137180220253298
in787356301072270
the877356301073179124
proportion1024356301074976123173223250281299347396
of1443356301074872
patients1538356301075091118137181229256291
with1852356301076584112160
normal340370301074999127203244264
spirometry624370301074192112139187263308337365409
finding1053370301073152101151171220270
from1344370301073159107183
17%1548370301075189156
to1725370301073583
83%)1828370301075296162185
and340384301074190139
an499384301074897
increase615384301072674115142185226260304
in939384301072674
the1033384301073483128
mean11873843010774119160208
ACT14153843010760109155
score1590384301074081128156199
(from180938430107315381128203
16.734039830107448399142
to502398301073481
23.8).602398301075094109155177190
Moreover,8183983010770119145188237278321347359
55%1197398301075091155
of1372398301075377
patients1469398301075697124143187235262297
achieved1786398301074687135153197340412301074083132
the491412301072572116
maximum6234123010773113152171243290362
ACT10014123010752101146
score.1163412301073373119145187202
Achieving1381412301075291138156199239258305354
asthma1751412301074173102149222262
control340426301074188138166193241262
was6294263010766108142
hindered792426301075675124174219247291342
by1154426301075798
active1272426301074890121141183227
smoking15194263010741116165205226275325
and1865426301074897148
the340440301072877122
age483440301074898143
≥6534403010754
40728440301075197
years.845440301074791132159194211
On10834403010762112
the1215440301073584129
contrary,1364440301074895145172199242269313325
patients17094403010757100127147191240268303
with340454301076584113161
extrinsic521454301075090120147167215248266306
asthma847454301074881110158232273
had1140454301075595145
a13054543010747
better13724543010756101129160202229
chance1621454301074694135183224267
for1907454301073178105
treatment340468301072856100141168244289338366
success726468301074189130170213248282
by1028468301075797
using1146468301075589107156207
a13734683010748
fixed‑dose144146830107315292135186215268317351396
ICS/1858468301072678122154
LABA340482301074095140192
combination.552482301074087161210230277318345364412461477
In480496301071965
our558496301074894118
study,689496301073360106154192202
we9034963010765107
chose1023496301074086132163206
a12414963010741
combination1295496301074085157204221267306331348394440
of1748496301074870
pharmacological18314963010749961351593405103010776116157203222271321339379420438
and797510301074796145
non‑pharmacological966510301075098147175225274315341416456497543562611661679719760778
approaches1763510301074797147174221340524301074283131176209
in569524301072776
order664524301075784133177203
to887524301073683
achieve990524301075091139157201242286
an1295524301075099
improvement14135243010727102152179226267310385429478505
in1937524301072776
asthma340538301074172100146218257
control615538301074287134159184229247
in880538301072268
outpatient968538301074895121169209234251293339365
population.1353538301075097145192209248273290336383398
Results1771538301074688120165182208241
of340552301074870
numerous431552301074894165208232278324355
long‑term804552301072268115163189215256280353
clinical117555230107425976122139177217234
trials142755230107305573111129159
confirm1604552301074388135156174199271
the1893552301073177119
potential340566301074995120160205229246283300
of652566301074769
FSC733566301074178126
for87756630107186387
achieving976566301074078123139180218235280327
asthma131556630107407197143213251
control1578566301074083129153178222239
more18295663010773119143183
rapidly340580301072666113130177194232
andwith585580301074187134211229255301
a8995803010740
higher952580301074865111157199224
probability1189580301074974119167206254271288304330371
than1572580301072874113159
ICSmonotherapy.1748580301071464105191237340594301074895120167209234273321359369
The722594301074290132
GOAL8675943010756115163202
study1082594301073360107154193
showed1288594301073379126189230278
early1580594301074381106124162
signs175559430107345097143175
of1943594301074870
treatment34060830107275192129153224265310334
success686608301073377115151191222252
during950608301074893116133178224
the1186608301072873114
initial131760830107145975100116154170
dose1499608301074894124166
escalation1677608301074373111150166204228245290335
phase,340622301075097136168211223
where5866223010766113155180222
total826622301073378103143160
control1005622301074590137162187233251
was12796223010765105136
achieved1434622301074584131148190229271319
in1771622301072471
42%1860622301074888153
and340636301074187134
a4876363010740
good540636301074995142190
control743636301074084131155180225243
in1003636301071460
71%of1076636301074382141201223
patients1312636301075089114131173219243276
treatedwith160163630107285293131156197245322339365411
FSC.340650301074179129143
With496650301077492118164
continued673650301074085131156173219264306354
long‑term1045650301071461107155181207247272344
regular1402650301072768116161178217241
treatment,165665030107285394132157229271317342356
the340664301072876119
proportion483664301075076122172220246276293341389
of895664301074972
patients990664301075191117135178225251285
with1298664301076684111159
well‑controlled14806643010766109127144171213259306332358404423440483532
disease34067830107506799143182214258
increased617678301072471111136179218250294343
during984678301075097122140187236
the1239678301073381124
open‑label1387678301074998142190217236276325369387
phase1798678301075099139171214
to340692301072873
78%431692301074989154
(3).60369230107286989100
Despite7266923010758101133181198224265
the1009692301073379122
differences115469230107496688114155180221268307348380
between1556692301075093119185227270317
the1891692301073279121
designs340706301074992124140188234266
of628706301074871
the717706301073279122
GOAL8627063010756115164202
trial108270630107335876114132
and1232706301074692140
our1395706301074894119
real‑life1532706301073173111129154173190212254
study,1804706301073866112160199209
the340720301072874117
results475720301072869101147164190223
regarding716720301072870118157181228245291338
asthma1074720301074173100146218257
control1349720301074287134159184229247
seem1614720301073578121193
to1825720301073074
be1919720301075093
similar.340734301073450122138155194219229
Moreover,5847343010770117142183230269310335345
from94773430107204692164
a11267343010741
clinical118273430107405773119136175214232
point1428734301075097115161186
of1629734301074870
view,1714734301074058100163174
it1906734301071642
is1966734301071647
highly340748301074865112159176214
encouraging572748301074895134179225250290337354400448
that1038748301073279118143
it1199748301072450
is1267748301072354
possible1344748301075097129161177225243285
to1647748301073277
achieve1742748301074685131148190229270
well‑controlled3407623010765106124140166207251298323348393411427469517
asthma87076230107417299145217256
in1143762301071460
amajority12167623010741127166183229254272298338
of1567762301074870
patients1650762301075089115131173219244277
as1940762301074172
early340776301074482106124162
as515776301074172
after60077630107416392133157
threemonths77077630107287499140183269316362387434465
with1248776301076582108154
regular1415776301072768116162179217242
treatment167077630107275293132157229271317342
with2140258301076582109155
ICS/LABA2313258301071565106135175228271321
(12,265225830107195793106
13).277225830107448099110
Our28962583010760107132
observations3041258301074896128170195237277302319365412444
fully350225830107206784101139
confirm3654258301074085132214027230107244266139
such2294272301073479118164
conclusions.2473272301074185132171188234265281327374405420
At2909272301075377
the3004272301072672114
end3134272301074490138
of3287272301074870
the3375272301072672114
3-month3505272301074470142189236261307
period,2140286301075093117135181229243
only2402286301074895112150
2%25712863010744108
of2698286301074870
patients2787286301075089115132174220245278
still30832863010734627996112
had3214286301074887135
uncontrolled3368286301074894133177224249274319337354396444
asthma2140300301074172100146218257
according2411300301074179116161186233250296343
to2772300301072469
the2859300301072470113
ACT29863003010753100144
score.3144300301073372117142183196
Similarly,3354300301074258130147164202227245283293
as3661300301074172
in3751300301071561
randomized2140314301072766113160207279296331372420
clinical257531430107405874120137175215232
trials,282531430107255068106123154168
the3011314301072572114
likelihood314331430107173369110128144191237284333
for349431430107206691
achieving36013143010740791251421842140328301074260107156
asthma2315328301074779107155229269
control2602328301074693141167193239258
with2884328301076684111159
ICS/LABA3062328301072475118148189243288340
combination34203283010746921672162342813213483652140342301074895
was22583423010765105136
also241234230107466394141
confirmed2571342301074590137159177201274317365
in2954342301072470
real‑life3042342301073273111129155173190212254
surveys3314342301073884108151192230263
(2,359534230107287083
12).3696342301074985105117
Recently,2140356301074588127168214239257295305
a24623563010741
prospective,2520356301075075120152199243282311328367408421
non‑interventional2958356301074995142168186232258298323365406453478495541588627644
study3620356301073360106154192
of2140370301074972
a22313703010747
fixed229637030107304887129179
dose2499370301075098131175
ICS/LABA2692370301072576119149190245290341
combination3052370301074692166216234281322348366413462
therapy3532370301073482126151192242280
across2140384301074180104150182213
a23713843010746
spectrum2435384301073885129168197222268340
of2798384301074870
community‑based2886384301074590162234280326343369410436485524556598647
asthma3551384301074577104151222261
patients2140398301075091117134177224250284
in2442398301072471
a25313983010747
real‑life2596398301073274113131157176193216259
setting2873398301073982109138156203251
showed3142398301073986134198240289
a34503983010746
clinically351539830107456380127144183224241258297
relevant214041230107276886128167207253278
improvement2436412301072496144169215253295367410456481
in2935412301072470
asthma3023412301074678105152224263
status3304412301073866105131177209
(asthma353141230107286597124171243282
control2140426301074186134160186232250
according2409426301074686123169195242260307355
to2783426301073379
ACT28854263010753102146
scores,3050426301073978124150192225239
lung3308426301072471118166
function,3493426301072977124164193210257305320
quality2140440301074995133151167193234
of2389440301074870
life24774403010715325496
according2587440301074179116161186233250296343
to2948440301072469
AQLQ30324403010752109148204
scores3250440301073473117143184216
and3480440301074187135
severe36294403010734761151562140454301072768
exacerbations)2226454301074886126165206230279319344361408455486505
in2749454301072470
a28374543010746
diverse2905454301074966106147172204247
population3175454301074997145192209248273290337384
during3581454301075095120137184231
a21404683010741
one‑year2197468301074895137164203244282307
period2520468301075093118135181230
(14).276846830107226097116128
Additionally,22804823010753103154173202221270320361381400441453
regular2754482301073377128177197238265
long‑term3039482301072776126176205234277304380
treatment3440482301073562106147175250296345373
evidently2140496301074484104153196244271290330
decreases2487496301074993134160203243276320354
the2861496301072472117
extent2994496301074483114156204231
of3242496301074771
airway333049630107415986153195233
hyper‑responsiveness,35804963010748871371822084294966023429496602542949660494294966060429496609742949661334294966173429496620042949662154294966254429496629442949663404294966381429496641342949664454294966460
which27604963010765112129169216
is2995496301071648
reflected306349630107236589111154195225267317
in3399496301071664
a34794963010741
reduction35394963010723661161632032332522140524301074898
in2258524301072675
the2353524301073584129
underlying25025243010755104154199226246287307356406
asthmatic2928524301074882112161236277305324365
inflammation331352430107267599122163238313354382401450500
(15).2140538301072465103126140
Furthermore,2300538301074995122154203248275350399427471486
the2806538301073584129
stability2955538301074070112162182201220249292
of3267538301075580
maintaining33745383010774116135184211253272321340388438
asthma2140552301074174103151225266
control2425552301074390138165192239259
increases2703552301072270110137180220253297331
with3057552301076584112160
treatment3237552301073057100140167241285334360
duration3620552301074996123164214056630107274693141
(12).230056630107205996117130
Asthma2446566301075286114162234274
patients2736566301074990116134177225251285
treated304056630107245092132158200249
with3305566301076483110157
a34785663010741
control‑driven35355663010739851331591852312504294966067429496609242949660864294966093429496612642949661574294966195
approach2440566301074185130153198236275320
do2774566301074894
not2883566301074794120
usually3018566301074778124163181199238
require3275566301072264112159176202244
escalation35345663010743761151551742132392572140594301074897
of2254594301074872
maintenance23445943010774114133181208250298339387428470
pharmacological2832594301075098139165240280321368387435486504544586605
treatment345759430107255295135162236281329356
and2140608301074189139
their2299608301073583128147173
main24996083010774115133182
daily2701608301075596115134174
ICS2895608301072678121
doses30366083010756105138183217
are3273608301074774117
lower3410608301072674140183210
than3640608301073483124172
with2140622301076584112161
ICS2320622301071870113
monotherapy24516223010774122171219247295339365407457496
(3,296762230107226579
9,3065622301074456
15).3140622301074381104117
In3277622301071866
our3361622301074896122
group3502622301074975122170220
of3740622301074872
patients,2140636301075091118137181229256291307
we24706363010765109
noticed2602636301074897124143183225275
a28976363010745
clear2961636301074463107147173
tendency3154636301073274122172216264304347
towards3520636301073278143185211259292
a21406503010741
stepwise2197650301073362104153217236268311
lowering2528650301071663127170196215263311
of2856650301074771
the2946650301072472116
ICS3081650301071667109
dose3206650301074997130173
with3396650301076483111158
improving35746503010715881371632102140664301074160108157
the2317664301073381125
level2462664301072468108152171
of2652664301075377
asthma2749664301074579108156229270
control.3039664301074591140167194241260276
On33406643010760109
the3469664301073281125
other3613664301075380129173199
hand,2140678301074889137186201
we23586783010765108
must24826783010774121154183
acknowledge2682678301074081119168216281300344394443487
that3189678301072473113140
patients3346678301074991118136180228255289
with3652678301076584112160
no2140692301074897
FSC2256692301074484135
dose2413692301074998131175
modification26106923010774122172191215235275317344362410459
during3091692301074996123142190239
the3350692301073078122
3-month3494692301074472146195243270318
duration21407063010750100127171199219269319
of2480706301075682
the2582706301073686132
study2735706301074172122173215
(672971706301073175118
%)3117706301076891
were32357063010767112140185
treated3441706301073563108150178222274
in3736706301072776
accordance2140720301074181120167194242283331371414
with2573720301076585113161
the2754720301072776120
current2894720301074087114141184232259
guidelines3173720301074996115164208227246294338371
(3).356472030107246687101
Poor2280734301074693143170
adherence2470734301074898147192219262311353396
is2885734301072659
one29647343010755104149
of3133734301075579
the3232734301073484128
key3380734301074589129
reasons3529734301073377118151201250283
for214074830107247096
the2255748301073481125
failure239874830107307189106153179221
in2638748301072471
achieving2728748301074686133151194234252299348
the3095748301073381124
goals3243748301074997138156187
of3449748301075477
asthma3545748301074679107154227267
management.21407623010774114162202251294367411459485500
Globally,2665762301075776123173214232250289300
in2984762301072572
asthma3075762301074780108156229269
patients,3369762301074991117135178226252286301
adherence36907623010746952140776301074892117159206246288
is2446776301072254
lower2518776301072269133176201
than2738776301073078118165
in2922776301072168
other3011776301074874122165191
chronic3221776301074289115161209226266
diseases,350877630107496798142181213257289305
and3940258301074291141
ranges4101258301073375124174219253
from4373258301073159106182
28%4575258301075194161
to4756258301073582
43%4858258301075192159
(16).5036258301073171111133147
The52022583010749100145
overall5366258301075596140167209228246
adherence3940272301074292141186213257306347390
to4350272301073582
the4452272301073584129
asthma4600272301074982112161236277
treatment4897272301073562106146174249294343370
plan5287272301075777118167
can5474272301074890139
also394028630107415889136
be4091286301074992
enhanced4198286301074390136175222261302351
by4563286301074987
regular4669286301072263112158176215240
visits492328630107405890107133167
to5108286301072469
a51912863010741
healthcare5246286301074891129147174220260300325366
provider3940300301075076122161179227271296
(16).425530030107205897118130
As4400300301075387
shown4502300301073380127191239
in4760300301071561
the4840300301072471115
prospective4969300301075076122155203247287316334374416
phase5400300301075098137170213
of3940314301074871
the4030314301073178121
observational4173314301074897130173199242283309327374422461479
PRISMA4674314301074689108147216268
study,4961314301073664111160199210
regular5190314301073072121167185225251
monitoring54623143010774122394032830107496795141168187235284
involving4243328301072573113160179220239287336
outpatient45993283010754102130180222248267310359385
visits500332830107486799117145179
by5202328301075695
patients5316328301075798125143187235262296
with3940342301076786114163
complex4123342301074795170220240285325
management44743423010775117166207257302377422471498
of4992342301075579
disease,5091342301075675108153193227272286
along5397342301074867116165216
with3940356301076482108154
pharmacological4108356301074995134158230269308352370416464481519559576
therapy,4702356301072369112136176223261271
made49863563010773112159201
an5201356301074086
apparent5301356301074087135175199240286311
contribution3940370301073984130155180198245291318335380427
to4381370301072771
improving4470370301071585133158203241259304351
asthma483537030107407299145216254
control.5103370301074084130155180225243257
During53743703010757104128146191239
a39403843010740
one‑year3994384301074793135162200241279303
period,4311384301074891116133179227240
total456538430107277197136153
asthma473238430107407198144215253
control4999384301073983130155179224242
(ACT5259384301071969116159
score5431384301073372116141182
25)3940398301074488110
was40753983010766107140
achieved4234398301074787135153197237280330
in4583398301072572
22.2%4674398301075194109154220
of4913398301075478
the5010398301073482126
patients5161398301075091118136180228254288
and5469398301074794144
good3940412301075098148198
control4158412301074693142169195243262
in4440412301072573
58.7%,4532412301075194110154220237
which47944123010766115133174222
approaches5035412301074898148175222264305353397431
the5486412301073482127
proportion3940426301075076122171219245275293340388
of4344426301074871
patients4431426301075091117135178225251285
with4732426301076583111158
an4906426301074188
ACT50104263010753101146
score5172426301073373119145187
≥53754263010754
205445426301074486
in5549426301071764
our3940440301074895121
study4079440301073462109158197
(17).429544030107236298122134
Our44484403010760108133
study4600440301073361109157196
suggests4815440301073480128177220253281315
that5148440301072875115141
frequent530844030107245092141188231279305
visits394045430107416193111139174
and4133454301074896146
patient4298454301075798125144188236263
motivation45864543010775124151170211252279298346395
to5000454301073581
adhere5101454301074797145190216259
to5380454301073481
treatment54804543010734611043940468301074269144189238265
significantly4224468301074159109157176200220260302351378397438
contributed4681468301074795144171198217267316344387438
to5139468301073482
success5240468301074188129168211245279
in5539468301072574
the3940482301072875118
management40814823010774114161201249293365409456482
of4586482301074871
asthmatic4676482301074577105152225265291309348
patients.5047482301075091117135178225251285301
An53714823010752100
improper54894823010723963940496301074975120168212237
use4191496301074779121
of4327496301074770
an4411496301074087
inhaler4516496301071461107146164206231
device4761496301074991130148187228
is5007496301071546
one5067496301074895137
of5218496301074870
themost5307496301072370112200246278306
frequent394051030107245092141188231279304
reasons4263510301072972111143191238270
for455251030107267399
insufficient4670510301072168100147170196215255272315362388
asthma5077510301074476104151224264
control5360510301074288136162188234253
(18).3940524301072463101122135
Thus,4093524301074290137169184
we42955243010765108
added4421524301074189138181230
training467052430107275393111158176223271
in4960524301071865
inhaler5044524301071865112152170213239
skills530152430107337089107125157
and5476524301074188136
adherence3940538301074190138182208251298339381
to4340538301073480
the4439538301073482126
program4590538301075076123173199240313
of4923538301075477
scheduled5019538301074080128172222269287331381
visits.541953830107476598115143177194
Other3940552301076089137180206
important4165552301072497145194220250290338364
factors4548552301072970110139185211245
found4812552301072976123170219
to5050552301073379
decrease5153552301074993133159201240273316
the5488552301073381124
treatment394056630107275293130155226268314339
success4292566301073377116152192224255
include456556630107145997114159206248
active4826566301074078107124162203
smoking50425663010733103150186204250297
and5352566301074085132
the5498566301072773114
presence/number3940580301074975117149192239279320352396442515563607632
of4586580301074871
certain4671580301074082107137177194241
relevant493158030107226482125164204251277
comorbidities5222580301074086158205231280298346364394059430107274586118
(19,407659430107195793104
20).4193594301074484106117
Similar4324594301074157128145162201225
to4567594301072368
the4653594301072369111
observational4778594301074795127169193235275300317363410448466
ASIT5257594301075293109150
study5421594301073360106153192
(20),3940608301072464106127139
in4097608301071561
our4171608301074894119
study4304608301073360106154192
smoking45106083010733104151188207253300
and4824608301074086134
concurrence4972608301073984131170216240266307353392433
of5419608301074769
≥55026083010753
255696083010743
comorbidities3940622301074085158205231280298346363390408451483
showed4438622301073380127190233281
an4734622301074187
adverse4836622301074189129171196229272
impact5127622301071486135175214244
on5385622301074895
the5499622301072371113
likelihood394063630107193672113131148194241288336
of4290636301074770
achieving4374636301074079125142184223241287335
asthma472363630107407299146217256
control.4993636301074085132157182227246260
Therefore,5267636301074189132157198220266291332346
an3940650301074190
intervention4049650301072573100142168212256304331349397446
directed4514650301075674100143185215257308
at4841650301074774
smoking49356503010740113162200220268318
cessation5272650301074789123156198225243292340
and3940664301074086133
aggressive4086664301074087134159199231262279318359
treatment445866430107275293131156227269315340
of4811664301074769
comorbidities4894664301073983155201226273291338354380398439471
should5378664301073378125170187234
be3940678301074993
an4047678301074087
integral415267830107156187128176201241259
part4425678301075090115144
of4584678301074770
the4672678301072470113
care4799678301074080105147
of4960678301074770
asthma5044678301074173100147219258
patients.5316678301075090115133175222247281296
Although394069230107537198145193240288336
we42956923010765108
did4422692301074967115
not4557692301074895122
perform4698692301075094120146192218292
an5009692301074188
analysis5117692301074188128146185218235267
of5404692301074771
the5493692301072976120
impact3940706301071990137177216244
of4198706301074870
particular4282706301074989114143160199245262301325
comorbidities,4621706301074085157203229277294342359385403445476491
we51267063010764106
could5246706301073984130148195
conclude54557063010739841313940720301074058105153196
that4155720301073481121147
a43217203010746
subgroup4386720301073985134183209255302351
of4756720301075376
patients4857720301075090117135177225251285
with5166720301076583111158
chronic5343720301074593118164212230269
bronchitis3940734301075076122170209256274301319351
or4309734301074874
COPD44017343010751108153209
would46287343010765112159177225
have4871734301074988127169
had5059734301074888136
a52137343010741
lower5273734301071866129172198
treatment5489734301072753953940748301074167140183231257
success4212748301073480120158199232264
rate.449574830107246490132146
This4657748301074290108140
could4812748301074186134152200
indicate5031748301071562111129168209235276
that5326748301072572112138
age5480748301074189132
and3940762301074189139
smoking40987623010740113161200220267317
are4434762301074773116
universal45697623010754102120161204230264306324
adverse4913762301074796137180206240284
prognostic5222762301075077124174222270303332350390
factors3940776301072465104134180206239
in4198776301072067
a42867763010740
multivariate43477763010774120138165183223264289308347373415
analysis.4781776301074289129147186219237269284
We50867763010774115
found5219776301072572119167215
a54537763010742
rep5514776301072870320376808339
<325776808342
0.0013314768083344782118150
ACT320324400834180116
=3334244008342
Asthma33912440083416992130188220
Control362724400834077115137158195211
Test38542440083326390113
(NATHAN398224400831964105134179221266
et426324400833456
al.,4335244008332476072
2004)442324400833468104140158
ACT52759240834180116
2554069240833469
ACT527510890834180116
<5406108908342
20546310890833468
Fig.320361501124771125149
4.337061501125075
Spirometry349062001073984102128172243282308334373
findings38796200107234288133152198243272
over416862001074582119145
the432962001072672111
study445662001073157103148185
period465762001074584110128173219
(n=494)489362001072367121164204246267
Baseline34772316083356895130145160198233
visit3726231608331477388110
Visit3928231608336527893116
14059231608334
Visit4280231608336527893115
24411231608334
Visit4631231608336527893115
34762231608334
Visit4982231608336527893115
45113231608334
ACT527510070834180116
20–24540610070833468106138170
Patients3224173847127230577689118151169193
(%)32241532471272135772
90331710270833470
%3402102708352
1003293894083336499
%340389408350
80331711600833469
%3402116008351
70332013020833467
%3403130208351
60331714350833470
%3402143508352
50331915730833468
%3403157308351
40331717060833470
%3402170608352
30331818430833469
%3402184308352
20331919760833468
%3403197608351
10332121090833466
%3402210908352
03353225208334
%3402225208352
1360890107229
%365190107244
76359916620722957
%3668166207245
23359910740722959
%3669107407244
1139469790722954
%401297907244
59394614530722958
%4016145307244
30394620280722959
%4018202807244
12429321660722956
%4361216607244
57429316670722958
%4364166707244
31429310970722956
%4362109707244
42465612180722958
%4725121807244
53465617930722958
%4725179307244
54656221507229
%4699221507244
25008224907229
%5051224907244
44500819120722961
%5082191207244
55500813750722958
%5079137507244
p34076808339
<39476808342
0.001451768083344782118150
OVD34023440834783130
=485234408342
obstructive54223440833777103127148186219243258290325
ventilatory88223440833266104126141156188210247269303
disorder,12002344083385379118139177212233243
VD145923440833582
=1556234408342
ventilatory161323440833266104126141156189210247269303
disorder19312344083385380118139178212234
Mild2112901083547085124
grade2251901083386093132167
if24339010831434
OVD24829010834783130
Severe211211180833268100134155189
or231711180833758
very23911118083316687121
severe25271118083266194128149183
OVD272611180834782129
Fig.34061601124771124149
3.50461601125073
Spirometry62262101073983102127171242280306332371
findings10096210107213985130148194239268
over129162101074582119144
the145262101072369107
study157262101073157103148185
period177062101074584109127172218
(n200462101072265
=2083621010753
494)215062101074180122143
Baseline7582156083356895130145160198233
visit1007215608331477388110
Visit1284215608336527893115
11415215608334
Visit1713215608336527893115
21844215608334
Visit2143215608336527893115
32274215608334
Visit2567215608336527893115
42698215608334
Moderate211210180835493132167189222243277
grade24041018083386093132167
of258610180833756
OVD265810180834782129
Combined211212120834077135174190228263302
VD243012120833582
Patients3851662471283356789104139177198226
(%)3851421471283197087
905238750833470
%60887508352
8052410040833469
%609100408351
7052611380833467
%609113808351
6052412670833470
%609126708352
5052514060833468
%609140608351
4052315350833470
%608153508352
3052416700833469
%608167008352
2052517980833468
%609179808351
1052819430833466
%609194308352
0559207208334
%608207208352
3785612320813365
%935123208150
3285617210813365
%935172108151
6871199108133
%919199108150
11130119510813360
%1375195108151
34129816500813367
%1378165008150
24173118070813364
%1810180708151
51742200408133
%1790200408150
19216618790813363
%2243187908150
11260119250813360
%2675192508151
42614202208133
%2662202208150
42177202408133
%2225202408150