930
KLINICKÁ341804301074588109168189242288347
FARMAKOLOGIE708804301074392139212266313373416475534555599
A13288043010753
FARMACIE1402804301074292139211266317337381
/18048043010757
Klin1880804301077091109157
Farmakol2057804301074278105179220258305325
Farm2402804301074178104179
2019;2601804301074386126164180
33(3):2801804301074385107150171185
11–163006804301074478120159198
/32238043010757
www.klinickafarmakologie.cz4568804301076513320121425327329234035839843647950254457164568672477179183988990895196610061045
121888026012657110
ORIGINÁLNÍ341207012673138172244278352422476549582
PRÁCE945207012660124196256314
Targeting34136501063066101141173206224265304
asthma66136501063872104146200240
control91736501063271113145181222253
in118536501061657
real‑life125836501063365107138160191208239271
clinical15453650106326381122140174216247
practice180836501063268109143176194229261
by208436501063470
using21703650106397188129168
ICS/LABA23533650106165185111142184219259
combination262836501063271125161179220260288306346388
Introduction343590014732101143186254325394448493524592661
The48376301074295141
majority655763010775118139190219241271316
of99376301075784
current109976301074999128157203254283
national1404763010757101130151202253296318
as174476301074985
well1860763010765111133154
as34390301074278
international44490301072880109155185237281311333385437481503
guidelines969903010759111132185232254276327375412
emphasize1403903010754132185237281318339378425
that185090301073890134164
the343104301072880128
primary493104301076090112189234263309
goals8251043010759111155177213
of1060104301075885
asthma1168104301075087119171248292
management14921043010775119171215268315393440492522
are343118301074271118
symptom483118301074488167220251301379
control8851183010750100152182212263285
and11931183010751102155
future1371118301073386117168198244
risk163811830107365894135
reduction179611830107368213618734313230107407293143193
(1,55813230107266780
2).65913230107477186
Moreover,7681323010771121150194245287332361374
the1164132301073080126
preferred1314132301074978123148194222251296348
stepwise1683132301073667111163229250285331
approach343146301074192144173222265307357
for722146301072776105
adjusting849146301074495116165200231251301352
pharmacological12231463010753104146174251293335384405455507528570613634
treatment1878146301073260105343160301074272150197249278
of644160301075884
asthma751160301075087119170248292
depends10651603010759106159208259312348
on14351603010758110
the1567160301073889137
current17261603010750101130160207258288
level343174301071965107152173
of538174301075480
asthma639174301074782113163238281
control941174301074695145174203251273
(1,123517430107307284
2).134117430107497388
Although1451174301075980109159210260311361
such1833174301074088131181
a3431883010741
strategy40518830107376896140169213265307
is734188301072156
effective812188301074672101146189221242285330
in1163188301072272
the1256188301073181127
majority14081883010774116137187215237266311
of1740188301075177
patients1842188301074993122142343202301074495124161
(3),526202301073277100116
experience664202301075395147195223245291342384429
from1115202301073362112189
everyday1326202301075295141170215266309350
practice1698202301075988132175207228271316
indicates343216301071968120140182225254299334
a6992163010747
discrepancy768216301075676111153181226277321371413457
between12472163010756103132202247294344
the1612216301073585131
results1764216301073378114163183213250
of343230301074975
randomized440230301073680131183235312333372418471
controlled933230301075099150180209259281302349402
trials135723030107376688131152187
and15672303010750101153
clinical174223030107497191142163206250272
practice.343244301075078122164196217259303320
In684244301072069
the775244301072878124
setting920244301073480110142163212264
of1205244301074874
unselected1301244301074797132178199245288320364416
asthma1739244301074176107157232275
populations,3432583010751104157209231274305326378430466484
observational,8502583010758111148196225272317347369420472516538556
cross‑sectional1428258301075080130167203233269317362395416468520564586
surveys343272301073484113160206248285
show,650272301074394145213228
in900272301072879
general,10012723010758105156203233277298316
a13392723010750
high1411272301075879131182
frequency1615272301073363109162212259310354399
of343286301074875
symptoms439286301074386163215245294371406
and8672863010750100152
activity1041286301075093125146190211242286
limitation1349286301072849125145176219249270320371
related1742286301073581102145174219272
to343300301072876
asthma441300301074681112162237279
(4,74230030107297289
5,852300301074965
6).93830030107497388
In1048300301072474
addition,1143300301074697149169199220269320337
patients1502300301075498127147193243271308
have1832300301075395137182
a3433143010741
tendency405314301073175125176222272314359
to785314301073079
overestimate885314301075193138166211247277298373416445489
the1395314301073181127
level1543314301072268110155176
of1741314301075076
their1839314301073080126147175
asthma343328301074176107157232275
control639328301074290141170198247268
(6).92932830107266993108
Along483342301075273122172222
with725342301076484114163
a9083423010740
proper968342301074977125176222250
choice1238342301073989138158200243
of1501342301074773
medication15933423010773119170190231274302322371421
and343356301074191142
treatment506356301073362107149177253299349378
of905356301075379
comorbidities,1006356301074593169219248300321372392422443488524542
an1569356301074696
essential1686356301074985120166216244265307328
role34337030107267394138
is502370301071750
played571370301074869110149193243
by833370301074988
patient940370301074991119139183231259
education.1218370301074293140181223251271319368385
Our16223703010759108135
efforts177637030107436795143171202238
were3433843010765110138183
directed54738430107486997142185217261313
at880384301074170
modification9703843010774124176197222244286329358379429479
of1469384301074874
lifestyle156538430107173863109144175219241287
and1872384301074191142
improvement343398301071997151181232276322401449501531
of896398301075886
adherence10043983010751104156204234281332377423
to1449398301073888
the1560398301073890138
disease1720398301076081117165209246293
management3434123010774117168210262308385431481510
regimen875412301073581133154229276326
(7).1223412301073379105120
Inhaled1365412301072878128171192239291
corticosteroids1678412301074897126160180223272307343426301072872100149170221256
(ICS)620426301073050104148174
are815426301074775119
the956426301073383129
cornerstone1107426301074694123173219248284315363413459
of1588426301075379
pharmacological16894263010755106148176252295343440301074190111162215236278322343
asthma708440301075086117168244287
therapy.1017440301073687134163207259300314
According13534403010762104145194224274295345397
to1772440301073786
the1880440301073687134
current343454301074192122152198250280
Global645454301076789141195240261
Initiative929454301072880101132154197228249294340
for1292454301073384114
Asthma14284543010763101133185263307
(GINA)1757454301073491113174230257
guidelines,343468301074998119170216237257306352388406
ICS770468301072680124
represent916468301073378129158203238284334363
the1300468301073585131
first‑line145346830107305280116147173195215265311
medication17924683010774120172192343482301074083112133183233
intended598482301072474102147197248294346
for965482301072978107
the1094482301073383129
regular1245482301073276128178198241269
treatment1535482301073462107149178253300349378
of1935482301075379
all34349630107416182
symptomatic446496301073275151202231280355398426447489
asthma955496301074176106156231274
patients1249496301074992121142187237265302
(GINA157249630107237899158212
2018).1804496301074488130171195210
However,3435103010757109176223266312341355
there720510301073788134163209
is951510301072863
a10365103010750
large1108510301072871100151198
group1328510301075887137188240
of1590510301075784
patients16965103010759103132154200251280318
who3435243010765115166
require530524301072772124173193222266
combination818524301074089165216237287329358379429479
therapy1319524301072878124152196247288
to1629524301072876
achieve1727524301074183133154199242287
asthma343538301074176107157232275
control.639538301074896147175204253274292
The9525383010750101147
addition11215383010748100151171201222272322
of1465538301075581
long‑acting1567538301072777128179208251293325346396447
β2-adrenoreceptor343552301075096125170223253300352405435482528574628659710740
agonists11065523010754107160213234271303342
(LABA)1471552301073680139188244271
to1765552301074192
ICS1880552301073187134
significantly343566301073455108159180207230273318369399421464
improves8305663010728105158188238282328365
symptoms1217566301074388166219250300378414
and16535663010751102155
lung1831566301072879130183
functions343580301072474124167199219269319354
in719580301071868
comparison808580301074089164216259287308343393444
to1273580301072876
the1371580301072777123
same1515580301073477153199
or1735580301074877
even1833580301074386131181
higher343594301074869119169215244
dose6085943010753103139185
of814594301075278
ICS913594301072477122
(8,105659430107287290
9).116859430107487287
Within1280594301077496126176196246
this1547594301073282103137
context,1706594301074492143171216257290308
the343608301072981130
GINA496608301077598160217
document7366083010767120166218297345398429
recommends1188608301074491137188268346395448502539
taking1750608301074591133157210264
advantage343622301074192135178228257300351397
of762622301075581
this865622301073686106141
combination1027622301074897172224245295337366387436487
in1535622301072777
treatment1633622301073665109151180256302352381
Steps343636301074270114166201
3-5565636301074675120
(2).70663630107267195110
The483650301074293138
purpose6416503010757106133184234268313
of974650301075579
our10736503010756105131
3-month1224650301075279155204254281330
prospective1574650301075785132167217262304335354396440
study343664301073463110160200
was5606643010765106139
to719664301072571
investigate810664301071664103146180209228277318345387
the1217664301072573117
treatment135466430107255194134161235279328354
of1725664301074872
bronchial1814664301074976123172343678301074087105144163
asthma521678301074173102149221261
with798678301076483110157
a9716783010740
fixed103167830107203977119168
ICS/LABA1218678301071666108139179233278328
combination1562678301074086158207226273312339357404452
paired343692301075091110136179229
with597692301076584112160
an777692301074593
intervention89069230107247298141167211255303330348396445
aimed1355692301074564137181232
at1606692301074673
a16996923010745
proper1769692301074976123173218245
inhaler343706301071967115155174218245
technique.608706301072871112160208226275323367382
Better1010706301074690118148191217
adherence1247706301074291139183210253301342384
to1651706301072875
the1746706301072876121
treatment188670630107295699343720301074168142186234261
regimen624720301072467117136209253301
would9437203010765112160179229
lead1191720301071761101150
to1361720301072572
a14507203010741
significant151172030107314998146165189208249290338365
improvement1896720301071689343734301075077124164207281325373400
in763734301071866
the848734301072876120
initial98873430107186684112131171190
level1198734301071862103146166
of1383734301074771
asthma1473734301074175104152225266
control1758734301074087135162189236256
in343748301071967
uncontrolled4307483010754103143190239266293340360379423473
asthma923748301074881111159233274
patients.1217748301075698125144188237264299316
A15527483010760
secondary1632748301074084126173222271312339382
objective343762301074898118162203233252294337
was7067623010766107141
to866762301073582
identify968762301072574119167194213237281
risk126876230107345386124
factors1411762301073173114144191218252
affecting168376230107487299143184215233282331
the343776301072876120
achievement483776301074181129148192232276349394442468
of971776301074872
asthma1063776301074174103151225265
control.1348776301074087136162189236256272
Materials21412130014799161203265309340401432482
and26512130014761130200
Methods287821300147100163206275343414465
Subjects21412415014356118184209268322363409
Adult22812583010753100147165192
asthma2493258301074173101148221261
patients2774258301075090116134177225250284
(≥3077258301072576
183173258301074482
years)3274258301074083122147181201
who34952583010765113160
had3675258301074888137
at2141272301074167
least2227272301072569108141169
a24152723010747
6-month2481272301075078153201249275322
history2822272301075572105133179205248
of3089272301075377
bronchial3190272301075077123171211258276316334
asthma3543272301074780108156229269
diagnosed2141286301074967106155202249282325374
according2534286301074383121167193240258305353
to2906286301073076
the3000286301073178121
national3142286301074888114132179227267285
guidelines3448286301074996113162205223241288331364
were21413003010764105130171
recruited2330300301072263102127174191217257305
by2649300301074987
the2754300301072369111
investigators288330030107156098139171198215262301326371396429
(1).33303003010719577384
All342830030107527087
enrolled3528300301074389114159177194236284
patients2141314301075091117135178226252286
failed244631430107307189107150200
to2665314301073379
meet27693143010774118162189
the2977314301073381125
pre‑defined3126314301075076119147198241264283330374423
criteria356831430107467291118160186204244
for214132830107247096
total2256328301073277104144162
asthma2437328301074577105153225265
control2721328301074489137163189235254
despite2998328301074892124173191218260
regular3277328301073072121168186225251
asthma3547328301074477105152225265
treatment214134230107275394132158229272318343
for250234230107196590
at2606342301074166
least269034230107155795127154
3months.28583423010744130177224249295327342
The3214342301074189131
criteria335934230107406582109150174192231
for360834230107196590
total3716342301072368214135630107286886
asthma2242356301074072100147220259
control2516356301074085133159184230249
(shown278335630107205198145208256
in3058356301071561
Table3134356301074276124143185
1)3334356301074460
were34093563010765107132174
based3598356301074990122165214
on2141370301074794
a22503703010740
composite2304370301074085157205252284301328369
outcomemeasure2687370301074794121158202275317404447486517563588629
resulting333437030107226496141159185203249297
from364937030107194591163
lung2141384301071965112160
function2319384301072067114153182200247294
assessment2628384301074072104147180212283326373399
(using304538430107206495112159207
spirometry),326738430107338199124170242285312337379401413
the3699384301072370113
frequency214139830107235091140186228275314355
of2510398301074770
symptomoccurrence,2594398301073473146194220265338399439477523548574615662701742755
use3363398301074879122
of3499398301074870
rescue358839830107226396135181224
therapy,2141412301072877121147189239278289
history2449412301075574106135182209252
of2720412301075578
exacerbations,2818412301075090131172214240291332359378426475508523
and3361412301074795145
Asthma3531412301075489117166240281
Control2141426301075298146172198245263
Test2423426301074886119148
(ACT)2590426301072981130174201
score2810426301074080126152194
(10).3023426301073069108130143
The3185426301074796140
exacerbation3344426301075089129169211237287328354372420468
frequency214144030107235092140186229276315356
data2512440301074888113153
referred268444030107226487129154180221270
to2973440301072369
the3060440301072471113
previous3188440301074975117156174221268299
3-month3502440301074470143190237263310
period2141454301074992116134179227
and2382454301074086133
the2528454301072874116
usage2657454301074778118165207
of2877454301074769
rescue296445430107226394133178220
therapy3198454301072773115140179226264
applied3475454301074088135153170211259
in3752454301071460
the2141468301072875118
week22784683010765108152189
before2486468301074993116163189231
the2736468301072775118
baseline2873468301074990123166184202249292
visit.318446830107405991108135151
Exacerbation3353468301074283123163204230279320346364411459
events2141482301074483126173199233
were23894823010765107133175
defined2579482301074992115134180224273
according2867482301074180118164190237255302350
to3236482301072470
the3325482301072471114
GINA3454482301075674131182
20173651482301074486125161
document.2141496301074996136183256299346372387
The2543496301074291134
study2692496301073361108157196
was29034963010765105137
approved3055496301074190139165211250292341
by3411496301075088
the3518496301072471114
local3651496301071562103143161
ethics2141510301074471118136175209
committees2366510301074085159231249276306347391424
and2806510301074188136
was29585103010765106138
conducted3112510301074086134182229268298339388
in3519510301071663
accordance35985103010741801181641902141524301074988135174216
with2371524301076583110157
the2547524301072471114
Declaration26755243010758102142160199224265291309355403
of3092524301074871
Helsinki3178524301075699117149166213249269
and3461524301074188136
Good36125243010756104151200
Clinical214153830107516987134151191231249
Practice2411538301074670111151180198237279
guidelines.2711538301074996114162205223241288331364380
The3110538301074493136
patients3267538301075091117135178225251285
signed3571538301073653101148191241
an2141552301074187
informed224755230107156183130156228271320
consent2582552301074085132164207254280
formbefore288055230107206692165229272295341367409
being3303552301074993111157205
enrolled3523552301074390115161180197240288
in2141566301071966
the2226566301072774117
study.2362566301073361108156196207
Study2141591501435690154220273
Design24435915014378137182206271335
and28065915014356119185
Interventions3019591501432690126182217276333397432457521586630
Our22816083010762115144
study2447608301076294146199243
was27126083010794139176
a29106083010769
3-month,30026083010772102181234286316368386
multicenter,3411608301071021541752062282723183702141622301072973101113
open‑label,22756223010756108155205234255298349396416432
prospective2728622301075886135170221268311342362405450
real‑life3199622301073478120140169191210235280
study3500622301074272122173215
in3736622301072676
adult2141636301074190138157185
patients2345636301075697124143187235262297
with2667636301076584112161
bronchial2847636301075582130178219267285326344
asthma3211636301074780109157231271
who35086363010765113162
did3689636301075574123
not2141650301074998126
meet22946503010774119165193
the2507650301073584129
criteria265665030107487594123166193213254
for2930650301073179107
total3057650301073582110152171
asthma3248650301074882112161236277
control3545650301074795144172199247267
(Table2141664301072368102150169212
1).236866430107436073
A24566643010752
total252766430107246995136154
of2696664301074771
402782664301074388
selected288566430107337695137178207248297
outpatient3197664301074895122170211237255298345371
offices358366430107477097116155196229
which21416783010764112129169215
specialized2372678301073381125165183222241258294336385
either277267830107436188136179204
in2995678301071662
clinical307367830107395875122140179219238
immunology/3330678301071587159205252299318365414454482
allergology214169230107416078122148196244264312361402
or2559692301074875
pneumology/phthisiology2650692301075098142190263311331379428469498545593620668687719737785804852902942
in3612692301071663
the3695692301072573117
Slovak2141706301074261109149191229
Republic2389706301075296146194243263282322
participated2731706301075597123154173213232281323350393443
in3193706301072573
the3286706301073482126
study.3432706301074069117166206218
The3670706301074898142
goal2141720301074997139158
of2321720301074771
our2414720301074896123
study2556720301073665113162203
was27817203010764106139
to2940720301073076
reflect303672030107297295118162203233
the3289720301073078122
settings3431720301073680108138157205254287
of3740720301074872
routine2141734301072774122150169217261
clinical242273430107405977125143184225244
practice.2686734301074976118159189208248290305
Within2281748301077492118165181227
the2526748301072975118
study2662748301073461108155194
period,2874748301075093118135181230244
all313674830107415875
enrolled3230748301074390114159177194236285
patients3533748301075090115132174220245279
underwent2141762301074895143185210277319366391
a25507623010746
total2614762301073378104144162
of2799762301074870
five288776230107294787128
visits303476230107456394111138171
according3223762301074685123168193240257304352
to3593762301073378
the3689762301073380122
protocol.2141776301075177124150197238284303317
The2477776301074898141
initial263777630107257290117135175193
baseline2854776301075192125168187204252296
visit316877630107476698115142
was33347763010767108140
followed349377630107307796113161226269319
by3939216301075087
a40422163010741
subsequent4099216301073379126158200248294337383408
„visit452521630107246078108125151
1“4692216301074464
and4772216301074187135
„visit492521630107246077108125151
2“5092216301074468
at5176216301074166
two‑week5260216301072692138165229270313350
intervals.393923030107196590131155197237254285300
„Visit425723030107307089120136162
3“4441230301074467
and4526230301074591138
„visit468223030107306683114131157
4“4860230301074468
were49492303010765107131173
carried5139230301074484108134151193241
out5401230301074895121
at5540230301074470
4-week3939244301074471135176219256
intervals.421324430107206691132156199238255286301
At4534244301075277
the4629244301072975118
„baseline4765244301072776116148190207224270312
visit“,509724430107405889105132159168
the5282244301073076119
physician5420244301075097133165393925830107195977117165
recorded4123258301073375116163189238281332
the4474258301073382126
following:461925830107297695113161227245293342356
complete4994258301074793168217236280307350
clinical536325830107466482130147187229247
history,393927230107506799128174201244254
demographic4217272301075194169217267293334384433450490
data,4731272301075191118159174
disease4929272301075068100144184217261
symptoms,5209272301073980155205232278353386401
data3939286301074987113152
on4104286301074894
comorbidities4211286301074085157203228276293341357383400442474
(according470228630107195694131176201247264309357
to5072286301072772
availablemedical51572863010741781181351511902372552973834263939300301075067106147164
records),4122300301073274114160185233264284296
exacerbation4437300301074988128168209234284324350368415463
history,492330030107496698126171197239249
and5191300301074693142
current5351300301074693118144186233259
asthma3939314301074172100146218257
treatment421431430107285394133158230272319344
including4576314301071965104121167214231277325
the4919314301072875117
frequency505431430107255092140185228274313353
of5426314301074870
reliever5514314301072769393932830107193679118160185
medication41483283010774117166183222263288306353400
use.4571328301074980123137
Every4726328301074786128153195
patient4944328301075191117134177224249
underwent5216328301074996144187212279321368394
spirometry393934230107338097121165237279304328369
testingwith432134230107276798125142187234311328353399
subsequent4733342301073377124155197245290331377401
interpretation515234230107135983123148195220260286325350366412458
of3939356301074870
lung4027356301071662108156
function4200356301072168114153182199245292
tests451035630107246597124157
(11),468535630107215992107119
and4819356301074187135
completed4969356301074085157205223265291332380
an5364356301074187
ACT54663563010752100144
questionnaire.3939370301074995137169196213259306352391408432474487
The4439370301074290132
physician4584370301075097134166182221237276322
objectively4919370301074897114156195224241280322339377
assessed5310370301074072103146178209252300
the3939384301072875117
level4074384301072467106148165
of4262384301074871
asthma4351384301074677105151224263
control4632384301074590137162188233251
and4901384301074693140
decided5064384301075092132149196239287
on5374384301074896
the5488384301073279122
patient’s3939398301075090115132174220245262291
eligibility424639830107446178125142190207224241267308
for457239830107226792
enrollment4681398301074390114159177194265308354379
in5078398301071763
the5159398301072673115
study,5290398301073461107155193203
according55093983010741803939412301074085110156173219267
to4224412301072670
the4312412301072672115
inclusion4445412301071662101118164195211258304
criteria.476541230107406582109149174192230245
Finally,5025412301074259105144161177216225
treatment526841230107265192130156228270317342
with3939426301076481107152
a41034263010741
fixed‑dose416142630107183572112159185233278309351
combination4524426301074083154201218263301326342387433
ICS/LABA4975426301071362102131170222264313
fluticasone5305426301071939831091251632022322783939440301074890
propionate/salmeterol4041440301075074119167184230276314339379410438478495565607633673697742760
xinafoate4813440301073956101140161206245270311
in5141440301071459
dry5213440301074973114
powder5339440301074996159205247271
inhaler3939454301071967115155173217242
DiskusTM4205454301076078110148196228263334
(FSC)4557454301073071110161186
was47674543010767108140
prescribed4931454301075177120153193219237287331381
with5336454301076785112160
an5515454301074795
intention393946830107196589130176201218264310
to4262468301072872
achieve4347468301074180125142184222264
andmaintain4623468301074187135221260276322347386403449
asthma508546830107407299145216255
control.5353468301074084131156180225243257
All393948230107537087
patients4040482301074989115132174220245278
were43324823010765107132173
instructed452348230107156192119144191229258299347
by4884482301075087
a49854823010741
physician5040482301075097134166182221238276322
and/or5377482301074087134165207233
a39394963010741
trained399349630107285393109156198246
nurse4252496301074994119151194
on4459496301074894
the4567496301072774116
principles469649630107507593139178194242260302334
of5043496301074870
proper5126496301075075120169212236
inhaler5380496301071460107146163205230
handling3939510301074887133181198215261308
and4262510301074187135
the4415510301072471113
importance4546510301071687135182207236276322361402
of4962510301074870
treatment505051030107255091129155227269316341
adherence.54055103010741891351773939524301072667112150190202
At4154524301075276
all424252430107405773
following43335243010718638096142204221266312
visits465852430107405787103129161
(i.e.,48365243010719354990102116
„visits496452430107266178108124150182
1-4“),5158524301074465108131155167
data5337524301074887111150
collection5499524301074084393953830107193678117146163209256
according4208538301074179116161186232249295343
to4564538301072873
the4650538301072774116
protocol4779538301075075120146191230275292
was50855383010765104136
performed5234538301074992117142188213285328376
in3939552301071964
order4016552301074873119161185
to4214552301072772
recognize4299552301072667106150198244261295336
possible4648552301074996128159175222240282
changes4942552301074086125171218260291
in5251552301071459
the5323552301072874116
level545755230107145594135152
of3939566301074870
asthma4024566301074173100146218257
control4296566301074085132157182227245
(including455956630107213884122139185233250296343
pulmonary4917566301075097114185232279318342383
function5318566301072168115153182199245292
testing,393958030107276798124140185231244
ACT4195580301075298141
questionnaire,4347580301074893134165191207252298343380397420460472
relievermedication48315803010726668398139177217241325367413430467505530546591636
use,5479580301074777119131
and3939594301074086133
occurrence4084594301074886123168192217257303341381
of4477594301074769
symptoms)4558594301073472144191216260331362381
andmedication4951594301074186133218260308324362401425442487534
adherence54975943010740873939608301074890114155201239279
(an4236608301071855100
interviewaimed435460830107145984124149190208249312365381452494542
at4909608301074065
verification4987608301074081106123144162200239264281327373
of5373608301074769
days5455608301074887123155
covered3939622301074086124166191233281
with4243622301076683110157
the4418622301073380122
recommended4558622301073273113158231304346393441484533
use5113622301074980123
of5259622301074870
prescribed53526223010750761171491892142313939636301075093141
asthma4100636301074173100146218257
medication).43776363010774117165182220260285302348395415426
The4824636301074189132
patient’s4976636301075090115132174220245262291
physician5288636301074996133165182220237275322
ultimately393965030107486591108180219244285302340
decided4297650301074991131147195237285
on4600650301074895
FSC4712650301074280130
dosage4859650301074996127167215257
for513465030107236994
the5246650301072874117
period5380650301075093118135181230
until3939664301074894119136153
the4110664301072672115
next4241664301074891128157
visit.441466430107415990106132147
Statistical3939689501435690145181206249288313366421446
methods44146895014399157194258323389433
Discrete4079706301075876107145170211237278
(qualitative)4375706301072469115154171187214253278295335376396
variables4789706301074181105123161209227269301
were51087063010765107132173
specified5299706301073481124164180203221263311
utilizing393972030107497694112129165183231280
absolute4238720301074696128176195242269311
and4568720301074795144
relative473072030107337593133160177218261
frequency500972030107295699148195239287327369
(n,539672030107307590
%).5509720301076889101
The3939734301074393137
continuous4095734301074693141168186234281329377410
variables4524734301074788114133173222241285318
were48667343010767111136179
analyzed5064734301074795136154194232275325
using5413734301075082100147197
arithmeticmean393974830107416583109155227270296313351438480518565
and4517748301074187134
standard4665748301073360100146194232257303
deviation4982748301074891130147186211228274321
(SD).5321748301071957112132144
The5478748301074289132
significance393976230107345097144160182200239279325364404
of4360762301074870
the4448762301072774116
type4582762301072768117160
of4759762301074870
variable4846762301074180105123161209227269
and5132762301074187135
the5285762301072773115
numbers54187623010748931653939776301075093117150
of4102776301074870
groups4186776301074973119165213245
comparedwas4444776301074085157205245269310359437477508
tested4966776301072768100127168216
through519677630107277498144190238284
the5493776301072874117
Tab.214161601124992147170
1.232961601125071
Criteria24456210107487492118154180198243
for27046210107236894
total28146210107267096139157
asthma298862101074575101147218263
control326762101073881128153178222241
according352462101074583119162188231249295340
to388162101072670
the396762101072672110
study409362101073158103148185
protocol429562101074571115141184223266284
Characteristic21727590984793135164205242272314343364398428449485
Total39087590984283112154175
asthma41007590984074103150218260
control43767590983681128156185231253
Day-time21728820955288123148173190256295
symptoms24858820953067133178203244311340
None39088820955195138178
Limitation217210020953653119136161198222240283326
of251610020954264
activities259710020953773100118154172197214254284
None390810020955195138178
Night-time217211220955168112155179201227244309349
symptoms/awakenings253911220952966133177202244310340369403461498532571614631674718747
None390811220955195138178
Use217212420955079119
of230812420954364
reliever/rescue2390124209523628096136172211235261283321351388431470
medication2878124209565105150167203240265282325368
None390812420955195138178
Lung217213620953678121165
functions235513620952164108144171188231275305
(FEV126771362095215895137176
and287013620953679124
FEV1/FVC301113620953774117155179217260305
ratio)33341362095236185102145165
Normal390813620955194119185222239
Exacerbations217214820953774111148186210254292316333376420450
None390814820955195138178
ACT217216020954791132
score232116020953066108133171
25390816020953979
FEV1217217220953569110145
=2331172209548
Forced23931722095357598130163203
expiratory261117220953468109126149187210249273308
volume29341722095337390130194228
at317717220954063
first3255172209520376088112
second33811722095286296134176217
FVC217218220953576118
=2305182209547
Forced23671822095357497130162203
vital25841822095345174113129
capacity272818220953372113154188204228263
ACT217219220954385123
=2309192209548
Asthma23711922095437295136200240
Control262619220954381123146169208225
Test28661922095356593116
(10)29971922095215488108